scholarly journals The LIFTMOR-M (Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men) trial: protocol for a semirandomised controlled trial of supervised targeted exercise to reduce risk of osteoporotic fracture in older men with low bone mass

BMJ Open ◽  
2017 ◽  
Vol 7 (6) ◽  
pp. e014951 ◽  
Author(s):  
Amy T Harding ◽  
Benjamin K Weeks ◽  
Steven L Watson ◽  
Belinda R Beck
Keyword(s):  
Bone Mass ◽  
Osteoporotic Fracture ◽  
Controlled Trial ◽  
Older Men ◽  
Trial Protocol ◽  
Low Bone Mass ◽  
Reduce Risk

scholarly journals Effects of Transdermal Testosterone on Bone and Muscle in Older Men with Low Bioavailable Testosterone Levels, Low Bone Mass, and Physical Frailty

2010 ◽  
Vol 58 (6) ◽  
pp. 1134-1143 ◽  
Author(s):  
Anne M. Kenny ◽  
Alison Kleppinger ◽  
Kristen Annis ◽  
Margaret Rathier ◽  
Bruce Browner ◽  
...  
Keyword(s):  
Bone Mass ◽  
Older Men ◽  
Low Bone Mass ◽  
Physical Frailty ◽  
Testosterone Levels ◽  
Bioavailable Testosterone

scholarly journals Characterization of Bone Metabolism in Hungarian Psoriatic Arthritis Patients: A Case–Control Study.

2020 ◽  
Author(s):  
Zsofia Petho ◽  
Edit Kalina ◽  
Zoltan Pap ◽  
Katalin Hodosi ◽  
Rebeka Falcsik ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Bone Mass ◽  
Fracture Risk ◽  
Disease Activity ◽  
Bone Metabolism ◽  
Osteoporotic Fracture ◽  
Independent Predictor ◽  
Low Bone Mass ◽  
Major Osteoporotic Fracture ◽  
Volumetric Bmd

Abstract Background: Skeletal manifestations are predominant in psoriatic arthritis (PsA). The aim of this cross-sectional, case-controlled study is the complex assessment of areal and volumetric bone mineral density (BMD), fracture risk, vitamin D status and bone turnover markers, and its association with disease-related variables.Methods: Lumbar spine (L1-L4) and femur neck (FN) areal, and distal radius (DR) volumetric BMD, 10-year probability of major and hip osteoporotic fracture as assessed by the fracture risk assessment (FRAX) tool, markers of bone metabolism and disease activity were assessed.Results: Upon comparison of the disease and age- and sex-matched control groups, there was a statistically significant difference in FN areal (0.955±0.145 g/cm2 vs. 1.034±0.148 g/cm2; p=0.001) and DR total volumetric (285.7±61.8 mg/cm3 vs. 369.6±23.6 mg/cm3; p<0.001) BMD, 10 year probability for major osteoporotic (5.0% (0.7%-32%) vs. 3.5% (0%-17.5%); p=0.003) and hip (1.1% (0%-16%) vs. 0.5% (0%-6.1%); p=0.002) fracture and 25-hydroxyvitamin D status (53 (10-120) nmol/L vs. 67 (10-137; p<0.001) nmol/L). As compared to areal assessment, volumetric BMD measurements identified a significantly higher number of patients with low bone mass (T-Score £ -1.00) (34% vs. 88%, p<0.001). Upon multiple linear regression analysis, disease activity score, as determined by DAS28 assessment, was an independent predictor of 10-year probability for major osteoporotic fracture (B (95%CI) = 1.351 (0.379–2.323); p = 0.007).Conclusion: In the studied PsA cohort, disease activity was an independent predictor of 10-year probability for a major osteoporotic fracture, and complemented assessment of volumetric and areal BMD assured better efficacy at identifying those with low bone mass.

scholarly journals The influence of antiresorptive bone medication on the effect of high-intensity resistance and impact training on osteoporotic fracture risk in postmenopausal women with low bone mass: protocol for the MEDEX-OP randomised controlled trial

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e029895
Author(s):  
Melanie Fischbacher ◽  
Benjamin K Weeks ◽  
Belinda R Beck
Keyword(s):  
Bone Mineral Density ◽  
Randomised Controlled Trial ◽  
Bone Mass ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
High Intensity ◽  
Controlled Trial ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Randomised Controlled

IntroductionAntiresorptive medications increase bone density and decrease vertebral fracture, while high-intensity resistance and impact training (HiRIT) increases balance, bone and muscle strength decreasing risk for falls and fractures. Medications are typically prescribed by doctors and exercise by exercise specialists, frequently in isolation.ObjectiveOur primary aim is to determine the effect of an 8-month HiRIT programme with or without osteoporosis medications on bone mineral density (BMD) of the spine and hip in postmenopausal women with low bone mass.Methods and analysisOne hundred and sixty postmenopausal women with low bone mass will be recruited from the community to participate in an 8-month randomised controlled trial. Participants will be on stable doses of antiresorptive bone medication for at least 12 months (n=80) or have not taken bone medications for at least 12 months (n=80). Participants will be block randomised, stratified by medication intake, to twice-weekly 40-min supervised sessions of HiRIT or a low-intensity exercise programme (control). Primary outcomes include change in lumbar spine and total hip areal bone mineral density. Secondary outcomes include whole body, femoral neck and forearm BMD, proximal femur bone geometry and volumetric density, vertebral morphology, body composition, anthropometry, physical function, posture, rate of falls, osteoarthritis symptoms, pelvic floor health, quality of life, physical activity enjoyment, resting blood pressure, safety and compliance. All outcomes will be assessed at baseline and 8 months and intention-to-treat and per-protocol analyses will be conducted. Repeated measure analysis of covariance will be used to determine intervention effects on outcome measures, controlling for initial values, compliance and other variables found to differ between groups at baseline.Ethics and disseminationThe study has been approved by Griffith University Human Research Ethics Committee (Ref: 2017/739). Results will be reported in peer-reviewed journals and at conferences.Trial registration numberAustralian New Zealand Clinical Trials Registry (ACTRN12617001511325).

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