scholarly journals Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e029293 ◽  
Author(s):  
Amanda Corley ◽  
India Lye ◽  
Jayshree D Lavana ◽  
Abhilasha Ahuja ◽  
Chris M Anstey ◽  
...  

IntroductionExtracorporeal membrane oxygenation (ECMO) provides cardiac and/or respiratory support when other therapies fail. Nosocomial infection is reported in up to 64% of patients receiving ECMO and increases morbidity and mortality. These patients are at high risk of infection due, in part, to the multiple invasive devices required in their management, the largest being the cannulae through which ECMO is delivered. Prevalence of nosocomial infection in ECMO patients, including ECMO cannula-related infection, is not well described across Australia and New Zealand.Methods and analysisThis is a prospective, observational point prevalence study of 12 months duration conducted at 11 ECMO centres across Australia and New Zealand. Data will be collected for every patient receiving ECMO during 12 predetermined data collection weeks. The primary outcome is the prevalence of laboratory-confirmed bloodstream infection, and suspected or probable nosocomial infections; and the secondary outcomes include describing ECMO cannula dressing and securement practices, and adherence to local dressing and securement guidelines. Data collection will be finalised by March 2019.Ethics and disseminationRelevant ethical and governance approvals have been received. Study results will describe the prevalence of suspected and confirmed nosocomial infection in adult, paediatric and neonatal patients receiving ECMO across Australia and New Zealand. It is expected that the results will be hypothesis generating and lead to interventional trials aimed at reducing the high infection rates seen in this cohort. Results will be published in peer-reviewed journals and presented at relevant conferences.Trial registration numberANZCTRN12618001109291; Pre-results.

2011 ◽  
Vol 39 (5) ◽  
pp. 926-935 ◽  
Author(s):  
K. M. Hewson-Conroy ◽  
A. R. Burrell ◽  
D. Elliott ◽  
S. A. R. Webb ◽  
I. M. Seppelt ◽  
...  

Resuscitation ◽  
2016 ◽  
Vol 100 ◽  
pp. 1-5 ◽  
Author(s):  
Krishnaswamy Sundararajan ◽  
Arthas Flabouris ◽  
Campbell Thompson ◽  
Ian Seppelt

Critical Care ◽  
2012 ◽  
Vol 16 (S1) ◽  
Author(s):  
NE Hammond ◽  
M Saxena ◽  
P Young ◽  
C Taylor ◽  
I Seppelt ◽  
...  

Critical Care ◽  
2011 ◽  
Vol 15 (S3) ◽  
Author(s):  
NE Hammond ◽  
MK Saxena ◽  
C Taylor ◽  
I Seppelt ◽  
P Glass ◽  
...  

BMJ Open ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. e035824 ◽  
Author(s):  
Irene Deftereos ◽  
Justin M C Yeung ◽  
Vanessa M Carter ◽  
Elizabeth Isenring ◽  
Nicole K Kiss

IntroductionNutritional intervention and prevention of malnutrition is significantly important for patients with upper gastrointestinal oesophageal, pancreatic and gastric cancer. However, there is limited information regarding nutritional status, and perioperative nutritional interventions that patients receive when undergoing curative surgery.Methods and analysisPatients diagnosed with upper gastrointestinal cancer, planned for curative intent resection across 27 Australian hospitals will be eligible to participate in this point prevalence study. The primary aim is to determine the prevalence of malnutrition in patients with upper gastrointestinal cancer at the time of surgery using subjective global assessment. Secondary aims are to determine the type and frequency of perioperative nutritional intervention received, the prevalence of clinically important weight loss and low muscle strength, and to investigate associations between the use of an evidence-based nutrition care pathway or protocol for the nutritional management of upper gastrointestinal surgical oncology patients and malnutrition prevalence. Data collection will be completed using a purpose-built data collection tool.Ethics and disseminationEthical approval was granted in May 2019 (LNR/51107/PMCC-2019). The design and reporting of this study comply with the Strengthening the Reporting of Observational Studies in Epidemiology checklist for reporting of observational cohort studies. Findings will be published in peer-reviewed scholarly journals and presented at relevant conferences. Results will assist in defining priority areas for research to improve patient outcomes.


2020 ◽  
Vol 22 (4) ◽  
pp. 355-360
Author(s):  
Melissa J Ankravs ◽  
◽  
Andrew A Udy ◽  
Kathleen Byrne ◽  
Serena Knowles ◽  
...  

Objective: To characterise the assessment and management of delirium in patients admitted to intensive care units (ICUs) in Australia and New Zealand. Methods: We conducted a multicentre observational point prevalence study across 44 adult Australian and New Zealand ICUs. Data were extracted for all patients in the ICU in terms of assessment and treatment of delirium. ICU-level data were collected regarding the use of explicit protocols related to delirium. Results: We studied 627 patients, with 54% (336/627) having at least one delirium screening assessment performed. The Confusion Assessment Method for the ICU (CAM-ICU) was the most frequently used tool (88%, 296/336). Of patients assessed, 20% (68) were identified to have delirium. Eighteen per cent (111) of patients were administered a drug to manage delirium, with 41% (46) of those receiving a drug having no recorded assessment for delirium on that day. Of the drugs used to treat delirium, quetiapine was the most frequently administered. Physical restraints were applied to 8% (48/626) of patients, but only 17% (8/48) of such patients had been diagnosed with delirium. Most physically restrained patients either did not have delirium diagnosed (31%, 15/48) or had no formal assessment recorded (52%, 25/48) on that day. Conclusions: On the study day, more than 50% of patients had a delirium screening assessment performed, with 20% of screened patients deemed to have delirium. Drugs that are prescribed to treat delirium and physical restraints were frequently used in the absence of delirium or the formal assessment for its presence.


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