Bidirectional association between migraine and rheumatoid arthritis: two longitudinal follow-up studies with a national sample cohort

ObjectiveTo investigate the bidirectional association between migraine and rheumatoid arthritis (RA).DesignTwo longitudinal follow-up studies.SettingData collected from a national cohort between 2002 and 2013 by the Korean National Health Insurance Service-Health Screening Cohort.ParticipantsIn cohort 1, matching resulted in the inclusion of 31 589 migraine patients and 126 356 control I participants. In cohort 2, matching resulted in the inclusion of 9287 RA patients and 37 148 control II participants.Primary and secondary outcome measuresThe HRs for RA in patients with migraine (cohort 1) and migraine in patients with RA (cohort 2) were analysed using stratified Cox proportional hazard models after adjusting for autoimmune disease, Charlson Comorbidity Index scores without rheumatoid diseases, obesity (body mass index), smoking and history of alcohol intake. Subgroup analyses stratified by age, sex, income and region of residence were also performed.ResultsThe incidence of RA in the migraine group (2.0% (640/31 589)) was higher than that in the control I group (1.4% (1709/126 356), p<0.001). The adjusted HR for RA in the migraine without aura group was 1.48 (95% CIs=1.34 to 1.63, p<0.001).The incidence of migraine in the RA group (6.4% (590/9287)) was higher than that in the control II group (4.6% (1721/37 148), p<0.001). The adjusted HR for migraine without aura in the RA group was 1.35 (95% CI=1.23 to 1.49, p<0.001).ConclusionMigraine increases the risk of RA, and RA is also associated with an increased risk of migraine.

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Bidirectional association between GERD and rheumatoid arthritis: two longitudinal follow-up studies using a national sample cohort

Clinical Rheumatology ◽

10.1007/s10067-020-05400-0 ◽

2020 ◽

Author(s):

So Young Kim ◽

Chanyang Min ◽

Bumjung Park ◽

Hyo Geun Choi

Keyword(s):

Rheumatoid Arthritis ◽

National Sample ◽

Bidirectional Association ◽

Follow Up Studies

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Bidirectional association between gallstones and renal stones: Two longitudinal follow-up studies using a national sample cohort

Scientific Reports ◽

10.1038/s41598-019-38964-2 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 1

Author(s):

So Young Kim ◽

Chang Myeon Song ◽

Hyun Lim ◽

Man Sup Lim ◽

Woojin Bang ◽

...

Keyword(s):

Renal Stones ◽

National Sample ◽

Bidirectional Association ◽

Follow Up Studies

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Anxiety and clinical outcomes of patients with acute coronary syndrome: a meta-analysis

BMJ Open ◽

10.1136/bmjopen-2019-034135 ◽

2020 ◽

Vol 10 (7) ◽

pp. e034135 ◽

Cited By ~ 1

Author(s):

Jie Li ◽

Feng Ji ◽

Junxian Song ◽

Xiangyang Gao ◽

Deguo Jiang ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Clinical Outcomes ◽

Mortality Risk ◽

Meta Analysis ◽

Secondary Outcome ◽

Coronary Syndrome ◽

Increased Risk ◽

Follow Up Studies ◽

Poor Outcomes

ObjectivesAnxiety has been suggested to be associated with poor outcomes in patients with acute coronary syndrome (ACS). However, results of previous follow-up studies were inconsistent. The aim of this meta-analysis was to evaluate the association between anxiety and clinical outcomes in patients with ACS, and to investigate the potential role of depression underlying the above association.DesignA meta-analysis of prospective follow-up studies.SettingHospitals.ParticipantsPatients with ACS.InterventionsWe included related prospective follow-up studies up through 20 July 2019 that were identified by searching PubMed and Embase databases. A random-effect model was used for the meta-analysis. Anxiety was evaluated by validated instruments at baseline.Primary and secondary outcome measuresWe determined the association between anxiety and risks of mortality and adverse cardiovascular events (MACEs) in patients with ACS.ResultsOur analysis included 17 studies involving 39 038 patients wqith ACS. Anxiety was independently associated with increased mortality risk (adjusted risk ratio (RR) 1.21, 95% CI 1.07 to 1.37, p=0.002) and MACEs (adjusted RR 1.47, 95% CI 1.24 to 1.74, p<0.001) in patients with ACS. Subgroup analyses showed that depression may at least partly confound the association between anxiety and poor outcomes in patients with ACS. Adjustment of depression significantly attenuated the association between anxiety and MACEs (adjusted RR 1.25, 95% CI 1.04 to 1.52, p=0.02). Moreover, anxiety was not significantly associated with mortality risk after adjusting for depression (adjusted RR 0.88, 95% CI 0.66 to 1.17, p=0.37).ConclusionsAnxiety is associated with increased risk of mortality and MACEs in patients with ACS. However, at least part of the association may be confounded by concurrent depressive symptoms in these patients.

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Increased risk of sudden sensory neural hearing loss in patients with rheumatoid arthritis: a longitudinal follow-up study using a national sample cohort

Clinical Rheumatology ◽

10.1007/s10067-018-4333-6 ◽

2018 ◽

Vol 38 (3) ◽

pp. 683-689 ◽

Cited By ~ 4

Author(s):

Sang-Yeon Lee ◽

Il Gyu Kong ◽

Dong Jun Oh ◽

Hyo Geun Choi

Keyword(s):

Rheumatoid Arthritis ◽

Hearing Loss ◽

National Sample ◽

Follow Up Study ◽

Increased Risk ◽

Sensory Neural ◽

Sensory Neural Hearing Loss

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Evaluation of the increased risk of spine fracture in patients with mood disorder compared with matched controls: a longitudinal follow-up study using a national sample cohort in Korea

BMJ Open ◽

10.1136/bmjopen-2018-027581 ◽

2019 ◽

Vol 9 (11) ◽

pp. e027581

Author(s):

So Young Kim ◽

Chanyang Min ◽

Bumjung Park ◽

Miyoung Kim ◽

Hyo Geun Choi

Keyword(s):

Mood Disorder ◽

National Sample ◽

Spine Fracture ◽

Secondary Outcome ◽

Control Group ◽

Follow Up Study ◽

Increased Risk ◽

History Of ◽

Age And Sex

ObjectiveTo evaluate the risk of spine fracture in patients with mood disorder using a nationwide cohort.DesignA longitudinal follow-up study.SettingClaims data for the population ≥20 years of age were collected from 2002 to 2013 for the Korean National Health Insurance Service-National Sample Cohort.ParticipantsA total of 60 140 individuals with mood disorder were matched with 240 560 individuals (control group) for age, sex, income, region of residence and osteoporosis.InterventionsIn both the mood disorder and control groups, the history of spine fracture was evaluated. The International Classification of Diseases 10th Revision codes for mood disorder (F31–F39) and spine fracture (S220 and S320) were included.Primary and secondary outcome measuresThe univariable and multivariable HRs and 95% CIs of spine fracture for patients with mood disorder were analysed using a stratified Cox proportional hazards model. Subgroup analyses were conducted according to the history of osteoporosis, age and sex.ResultsApproximately 3.3% (2011/60 140) of patients in the mood disorder group and 2.8% (6795/240 560) of individuals in the control group had spine fracture (p<0.001). The mood disorder group demonstrated a higher adjusted HR for spine fracture than the control group (multivariable HR=1.10, 95% CI 1.04 to 1.15, p<0.001). The participants without osteoporosis showed a higher HR of mood disorder for spine fracture than the control participants (multivariable HR=1.25, 95% CI 1.14 to 1.37, p<0.001). According to age and sex, this result was consistent in subgroups of women aged 20–39 and 40–59 years and men aged ≥60 years.ConclusionThe risk of spine fracture was increased in patients with mood disorder. The potential risk of spine fracture needs to be evaluated when managing patients with mood disorder.

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