scholarly journals Evaluation of the increased risk of spine fracture in patients with mood disorder compared with matched controls: a longitudinal follow-up study using a national sample cohort in Korea

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e027581
Author(s):  
So Young Kim ◽  
Chanyang Min ◽  
Bumjung Park ◽  
Miyoung Kim ◽  
Hyo Geun Choi
Keyword(s):  
Mood Disorder ◽  
National Sample ◽  
Spine Fracture ◽  
Secondary Outcome ◽  
Control Group ◽  
Follow Up Study ◽  
Increased Risk ◽  
History Of ◽  
Age And Sex

ObjectiveTo evaluate the risk of spine fracture in patients with mood disorder using a nationwide cohort.DesignA longitudinal follow-up study.SettingClaims data for the population ≥20 years of age were collected from 2002 to 2013 for the Korean National Health Insurance Service-National Sample Cohort.ParticipantsA total of 60 140 individuals with mood disorder were matched with 240 560 individuals (control group) for age, sex, income, region of residence and osteoporosis.InterventionsIn both the mood disorder and control groups, the history of spine fracture was evaluated. The International Classification of Diseases 10th Revision codes for mood disorder (F31–F39) and spine fracture (S220 and S320) were included.Primary and secondary outcome measuresThe univariable and multivariable HRs and 95% CIs of spine fracture for patients with mood disorder were analysed using a stratified Cox proportional hazards model. Subgroup analyses were conducted according to the history of osteoporosis, age and sex.ResultsApproximately 3.3% (2011/60 140) of patients in the mood disorder group and 2.8% (6795/240 560) of individuals in the control group had spine fracture (p<0.001). The mood disorder group demonstrated a higher adjusted HR for spine fracture than the control group (multivariable HR=1.10, 95% CI 1.04 to 1.15, p<0.001). The participants without osteoporosis showed a higher HR of mood disorder for spine fracture than the control participants (multivariable HR=1.25, 95% CI 1.14 to 1.37, p<0.001). According to age and sex, this result was consistent in subgroups of women aged 20–39 and 40–59 years and men aged ≥60 years.ConclusionThe risk of spine fracture was increased in patients with mood disorder. The potential risk of spine fracture needs to be evaluated when managing patients with mood disorder.

scholarly journals Risk of ischaemic stroke in patients with migraine: a longitudinal follow-up study using a national sample cohort in South Korea

BMJ Open ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. e027701 ◽  
Author(s):  
Sang-Yeon Lee ◽  
Jae-Sung Lim ◽  
Dong Jun Oh ◽  
Il Gyu Kong ◽  
Hyo Geun Choi
Keyword(s):  
South Korea ◽  
Ischaemic Stroke ◽  
Statistical Significance ◽  
Young Patients ◽  
Haemorrhagic Stroke ◽  
Control Group ◽  
Follow Up Study ◽  
Increased Risk ◽  
Migraine Group

ObjectiveAccumulating evidence has supported the association between migraine and stroke, but the causative association remains unclear. We aimed to investigate the risks of different types of stroke in patients with migraine.DesignA longitudinal follow-up study.SettingData collected from a national cohort between 2002 and 2013 by the South Korea Health Insurance Review and Assessment.ParticipantsWe extracted the data from patients with migraine (n=41 585) and 1:4 matched controls (n=1 66 340) and analysed the occurrence of ischaemic and haemorrhagic strokes. The migraine group included participants treated for migraine (International Classification of Disease-10 (ICD-10): G43)≥2 times. Haemorrhagic stroke (I60-I62) and ischaemic stroke (I63) were determined based on the admission histories. The crude and adjusted HRs were calculated using Cox proportional hazard models, and the 95% CI were determined. Subgroup analyses stratified by age and sex were also performed.ResultsHigher rates of ischaemic stroke were observed in the migraine group (2.3% [964/41,585]) than in the control group (2.0% [3294/166 340], P<0.001). The adjusted HR for ischaemic stroke was 1.18 (95% CI=1.10 to 1.26) in the migraine group (P<0.001). Compared with control subjects, participants who reported migraine with aura and migraine without aura had increased adjusted HRs of 1.44 (95% CI=1.09 to 1.89) and 1.15 (95% CI=1.06 to 1.24), respectively, for ischaemic stroke, but no increased risk of haemorrhagic stroke. In our subgroup analysis, a strong association between migraine and ischaemic stroke was observed in young patients, specifically young women. The contribution of migraine to the occurrence of ischaemic stroke was also observed in middle-aged women and old women (each P<0.05). The risk of haemorrhagic stroke did not reach statistical significance in any age group.ConclusionMigraine is associated with an increased risk of ischaemic stroke, but not haemorrhagic stroke.

scholarly journals Association of nephrolithiasis with the risk of cardiovascular diseases: a longitudinal follow-up study using a national health screening cohort

BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e040034
Author(s):  
So Young Kim ◽  
Woo Jin Bang ◽  
Chanyang Min ◽  
Hyo Geun Choi
Keyword(s):  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
National Health ◽  
Proportional Hazards Model ◽  
Health Screening ◽  
Cox Proportional Hazards Model ◽  
Secondary Outcome ◽  
Follow Up Study ◽  
Age And Sex

ObjectivesThe aim of this study was to explore the associations of stroke and ischaemic heart disease in patients with nephrolithiasis.DesignA longitudinal follow-up study.SettingData from the Korean National Health Insurance Service–Health Screening Cohort (2002–2013) were retrieved to identify the occurrence of nephrolithiasis.Participants and interventionsIn total, 19 103 patients with nephrolithiasis were matched at a 1:4 ratio with control participants for age, sex, income and region of residence.Primary and secondary outcome measuresThe occurrence of stroke and ischaemic heart disease was analysed in both patients with nephrolithiasis and control participants. The primary outcome was HRs of stroke and ischaemic heart disease in a stratified Cox proportional hazards model. Smoking, alcohol consumption, obesity and Charlson Comorbidity Index were adjusted for as covariates. Subgroup analyses according to age and sex were also performed.ResultsEight per cent (1615/19 103) of patients with nephrolithiasis and 7.2% (5476/76 412) of control participants had stroke. Nine per cent (1879/19 103) of patients with nephrolithiasis and 7.7% (5895/76 412) of control participants had ischaemic heart disease. Patients with nephrolithiasis had risks of stroke and ischaemic heart disease that were 1.18 times (95% CI=1.11 to 1.24) and 1.24 times (95% CI=1.18 to 1.31) those of the control participants, respectively. The age and sex subgroups showed consistent results.ConclusionsNephrolithiasis was associated with increased risks of stroke and ischaemic heart disease.

Increased risk of osteoporosis in patients with peptic ulcer: a follow-up study using a national sample cohort

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Hyo Geun Choi ◽  
Chae Chun Rhim ◽  
Ji Young Yoon ◽  
Bum Jung Park ◽  
Chan Yang Min ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
National Sample ◽  
Follow Up Study ◽  
Increased Risk

scholarly journals Increased Risk of Migraine in Patients with Temporomandibular Disorder: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 724
Author(s):  
Soo-Hwan Byun ◽  
Chanyang Min ◽  
Dae-Myoung Yoo ◽  
Byoung-Eun Yang ◽  
Hyo-Geun Choi
Keyword(s):  
Blood Pressure ◽  
National Health ◽  
Temporomandibular Disorder ◽  
Fasting Blood Glucose ◽  
Health Screening ◽  
Control Group ◽  
Follow Up Study ◽  
Kaplan Meier ◽  
Increased Risk

Background: The aim of this study was to investigate the association between temporomandibular disorder (TMD) and migraine through a longitudinal follow-up study using population data from a national health screening cohort. Methods: This cohort study used data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015. Of the 514,866 participants, 3884 TMD patients were matched at a 1:4 ratio with 15,536 control participants. Crude models and models adjusted for obesity, smoking, alcohol consumption, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, and Charlson Comorbidity Index (CCI) scores were calculated. Chi-squared test, Kaplan–Meier analysis, and two-tailed log-rank test were used for statistical analysis. Stratified Cox proportional hazard models were used to assess hazard ratios (HR) and 95% confidence intervals (CIs) for migraine in both control groups. Results: The adjusted HR for migraine was 2.10 (95% CI: 1.81–2.44) in the TMD group compared to the control group, which was consistent in subgroup analyses according to age, sex, and Kaplan–Meier analysis. Conclusions: This study demonstrated that TMD patients have a higher risk of migraine. These results suggest that dentists can decrease the risk of migraine in TMD patients by managing TMD properly.

scholarly journals Tonsillectomy does not reduce asthma in children: A longitudinal follow-up study using a national sample cohort

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
So Young Kim ◽  
Dong Jun Oh ◽  
Hyo Geun Choi
Keyword(s):  
Repeated Measures ◽  
Status Asthmaticus ◽  
National Sample ◽  
Control Group ◽  
Asthmatic Children ◽  
Asthma Status ◽  
Region Of Residence ◽  
History Of ◽  
And Control

Abstract This study aimed to investigate the occurrence of tonsillectomy in asthmatic children using a control group with a comparable frequency of a preoperative history of asthma. Asthmatic children ≤15 years old were collected from the Korean Health Insurance Review and Assessment Service - National Sample Cohort (HIRA-NSC) from 2002 through 2013. In study I, asthmatic children who had undergone a tonsillectomy (n = 2,326) and control I participants (n = 9,304) were selected and matched 1:4 for age, sex, income, and region of residence but not a preoperative history of asthma. In study II, a preoperative history of asthma was additionally matched for between the tonsillectomy (n = 2,280) and the new control II participants (n = 9,120). The margin of equivalence of difference (control-tonsillectomy) for asthma was set at −0.05 to 0.05 per year. In addition, repeated measures ANOVA was performed for tonsillectomy according to yearly changes in asthma, status asthmaticus, and admission. In study I, the preoperative frequencies of asthma, status asthmaticus, and admission were higher in the tonsillectomy group than in the control group (P ≤ 0.001). The frequencies of postoperative asthma, status asthmaticus, and admission were lower in the tonsillectomy group than in the control I group for 3 years. In study II, the frequencies of postoperative 1-, 2-, and 3-year asthma and admission were not lower in the tonsillectomy group than in the control II group. Tonsillectomy did not further reduce the frequency of asthma in patients who underwent this procedure compared to the control group when a preoperative history of asthma history was equally matched between the two groups.

scholarly journals Follow-up study of airway microbiota in children with persistent wheezing

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Lei Wu ◽  
Chencong Shen ◽  
Yuanling Chen ◽  
Xin Yang ◽  
Xiaofei Luo ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Prospective Observational Study ◽  
Lower Airway ◽  
Control Group ◽  
Follow Up Study ◽  
Microbial Dysbiosis ◽  
Increased Risk ◽  
Group A

Abstract Background Increasing evidence revealed that airway microbial dysbiosis was associated with increased risk of asthma, or persistent wheezing (PW). However, the role of lung microbiota in PW or wheezing recurrence remains poorly understood. Methods In this prospective observational study, we performed a longitudinal 16S rRNA-based microbiome survey on bronchoalveolar lavage (BAL) samples collected from 35 infants with PW and 28 age-matched infants (control group). A 2-year follow-up study on these PW patients was conducted. The compositions of lower airway microbiota were analyzed at the phylum and genus levels. Results Our study showed a clear difference in lower airway microbiota between PW children and the control group. Children with PW had a higher abundance of Elizabethkingia and Rothia, and lower abundance of Fusobacterium compared with the control group. At the end of the 2-year follow-up, 20 children with PW (57.1%) experienced at least one episode of wheezing, and 15 (42.9%) did not suffer from wheezing episodes. Furthermore, PW children with recurrence also had increased abundances of Elizabethkingia and Rothia relative to those who had no recurrence. Additionally, wheezing history, different gender, and caesarean section demonstrated a greater impact in airway microbiota compositions. Conclusion This study suggests that the alterations of lower airway microbiota could be strongly associated with the development of wheezing, and early airway microbial changes could also be associated with wheezing recurrence later in life.

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