Circulatory uses of prostaglandins

1984 ◽  
Vol 22 (26) ◽  
pp. 101-103
Keyword(s):  
Fatty Acids ◽  
Congenital Heart Disease ◽  
Arachidonic Acid ◽  
Heart Disease ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Congenital Heart ◽  
Peripheral Vascular ◽  
Naturally Occurring

Prostaglandins (PGs) are naturally-occurring fatty acids synthesised from arachidonic acid by cyclo-oxygenase enzymes. Two PGs with circulatory actions, alprostadil (PGE1; Prostin VR - Upjohn) and epoprostenol (prostacyclin, PGI2; Flolan - Wellcome, Cyclo-Prostin - Upjohn) are marketed in Britain. Both have already found a place; alprostadil for neonates with congenital heart disease, epoprostenol for use in extracorporeal circulations and in patients with severe peripheral vascular disease.

Inoperable pulmonary vascular disease in infants with congenital heart disease

1998 ◽  
Vol 66 (5) ◽  
pp. 1565-1570 ◽  
Author(s):  
Shigeo Yamaki ◽  
Ai Abe ◽  
Koichi Tabayashi ◽  
Masato Endo ◽  
Hitoshi Mohri ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Vascular Disease ◽  
Congenital Heart ◽  
Pulmonary Vascular Disease

Macroangiopathy in type II diabetes

1983 ◽  
Vol 104 (4_Suppl) ◽  
pp. S75-S78
Author(s):  
Antti Aro
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Type Ii Diabetes ◽  
Clinical Manifestations ◽  
Diabetic Patients ◽  
Type Ii ◽  
Peripheral Vascular ◽  
Middle Aged

ABSTRACT. Macroangiopathy is the most important cause of mortality and morbidity in type II diabetes. The atherosclerotic process in diabetes is similar to that found in non-diabetic subjects, but the laesions are more extensive and the clinical manifestations are more common in diabetic subjects than in the non-diabetic population. In diabetic patients from different populations, the prevalence of macroangiopathy is variable, and the relative frequency follows the pattern found in the respective non-diabetic populations. The relative risk of large vessel disease is in most populations higher for female than for male diabetics. Coronary heart disease is the most important manifestation of macroangiopathy while cerebrovascular disease and peripheral vascular disease are less frequent, although all these manifestations occur at increased frequency among middle-aged diabetic subjects. The incidence of peripheral vascular disease seems to increase with increasing duration of diabetes in middle-aged subjects, whereas coronary heart disease is particularly frequent in type II diabetes already at the time of the diagnosis. Key words: atherosclerosis, complications, diabetes mellitus, macroangiopathy, mortality.

Effects of Lifestyle Modification and Lipid Intake Variations on Patients with Peripheral Vascular Disease

2003 ◽  
Vol 73 (5) ◽  
pp. 389-398 ◽  
Author(s):  
Nestares ◽  
López-Jurado ◽  
Urbano ◽  
Seiquer ◽  
Ramírez-Tortosa ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Olive Oil ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Lifestyle Intervention ◽  
Physical Performance ◽  
Intervention Program ◽  
Peripheral Vascular ◽  
Lipoprotein Composition

The aim of the present study was to evaluate the effects of diets enriched in monounsaturated fatty acids (MUFA) (olive oil) or MUFA plus n-3 polyunsaturated fatty acids (PUFA) (olive oil plus fish oil), associated with an intervention program that focused on lifestyle habits, physical performance, plasma lipids, and lipoprotein composition in patients with peripheral vascular disease (PVD). A 15-month longitudinal nutritional and lifestyle intervention study was carried out with 24 free-living male patients aged 58.0 ± 2.2 years diagnosed with PVD (Fontaine grade II). The patients were clinically evaluated and counseled to change their dietary and lifestyle habits for six months, after this period they consumed an olive oil-based diet for three months; after a three-month wash-out period, their diet was supplemented with a combination of fish oil and olive oil for the final three months. Lifestyle interventions resulted in a significant decrease in cigarette smoking and an increase in physical activity. Claudicometry was lower at the end of the study than at the beginning. Intake of the fish oil supplement led to significant changes in lipid lipoprotein composition, decreasing low-density lipoprotein (LDL) cholesterol. The lifestyle intervention program, together with a high intake of olive plus fish oil, seems to produce important beneficial effects in nutritional management, physical performance, and clinical parameters of PVD patients.

Sign in / Sign up

Export Citation Format

Share Document