Cognitive therapy plus medication management is better than antidepressants alone for patients with severe depression

2015 ◽  
Vol 18 (3) ◽  
pp. 95-95
Author(s):  
Sharon C Sung
Keyword(s):  
Cognitive Therapy ◽  
Medication Management ◽  
Severe Depression ◽  
Better Than

Cognitive Therapy Versus Medications: Acute Treatment of Severe Depression

2004 ◽  
Author(s):  
Robert J. Derubeis ◽  
Jay D. Amsterdam ◽  
John P. O'Reardon ◽  
Paula R. Young
Keyword(s):  
Cognitive Therapy ◽  
Acute Treatment ◽  
Severe Depression

Treating Depression with SNRIs: Who Will Benefit Most?

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S11) ◽  
pp. 15-21 ◽  
Author(s):  
Michael T. Isaac
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Antidepressant Medication ◽  
Severe Depression ◽  
Antidepressant Activity ◽  
Noradrenergic System ◽  
Factors Influencing ◽  
Genetically Determined ◽  
Norepinephrine Reuptake ◽  
Better Than ◽  
Cyp 2D6

AbstractThere is evidence that the serotonin norepinephrine reuptake inhibitors (SNRIs) venlafaxine, milnacipran, and duloxetine, have probable superior antidepressant activity to most selective serotonin reuptake inhibitors (SSRIs), especially in more severe depression. Some patients, however, respond better than others to SNRIs. Several factors influencing response to milnacipran have been recently studied. The presence of certain polymorphisms related to noradrenergic neurotransmission has been shown to be related to different degrees or rapidity of response to milnacipran. In addition, patients with low pretreatment levels of plasma 3-methoxy-4-hydroxyphenylglycol have a better response to milnacipran. These recent genomic and neurochemical data confirm that milnacipran, in contrast to SSRIs and venlafaxine, has an impact on the noradrenergic system. Differences in metabolism determined by genetic variables in cytochrome P450 (CYP) 2D6 activity are a major determinant of venlafaxine levels to such an extent that genetically determined decreases in CYP 2D6 activity have been associated increased adverse effects. Milnacipran, which is not metabolized by the enzymes of the CYP system is not influenced by polymorphism of these enzymes. These preliminary data suggest that a patient's biochemical and pharmacogenetic characteristics may be useful in the future to help clinicians chose the most  effective antidepressant medication.

Cognitive Therapy versus Medication in the Treatment of Moderate to Severe Depression

2018 ◽  
Author(s):  
Daniel Barron ◽  
Robert Ostroff
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cognitive Therapy ◽  
Study Design ◽  
Clinical Case ◽  
Severe Depression ◽  
Major Depressive ◽  
Study Intervention ◽  
Landmark Study

This chapter provides a summary of a landmark study on major depressive disorder. Is paroxetine or cognitive therapy more effective in treating patients with moderate to severe major depressive disorder? Starting with that question, it describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case.

Two psychological treatments for hypochondriasis

1998 ◽  
Vol 173 (3) ◽  
pp. 218-225 ◽  
Author(s):  
David M. Clark ◽  
Paul M. Salkovskis ◽  
Ann Hackmann ◽  
Adrian Wells ◽  
Melanie Fennell ◽  
...  
Keyword(s):  
Stress Management ◽  
Cognitive Therapy ◽  
Specific Treatment ◽  
Post Treatment ◽  
Waiting List ◽  
Control Group ◽  
One Year ◽  
Almost All ◽  
Better Than

BackgroundHypochondriasis is generally considered difficult to manage. This study aimed to assess the effectiveness of cognitive therapy and to compare it with an equally credible, alternative treatment.MethodForty-eight patients with hypochondriasis were initially randomly assigned to either cognitive therapy, behavioural stress management or a no treatment waiting list control group. At the end of the waiting period, patients in the control group were randomly assigned to one of the two treatments. Assessments were at pre-, mid- and post-treatment or waiting list and at three-, six- and 12-month post-treatment follow-up.ResultsComparisons with the waiting list group showed both treatments were effective. Comparisons between the treatments showed that cognitive therapy was more effective than behavioural stress management on measures of hypochondriasis, but not general mood disturbance at mid-treatment and at post-treatment. One year after treatment patients who had received either treatment remained significantly better than before treatment, and on almost all measures the two therapies did not differ from each other.ConclusionsCognitive therapy is a specific treatment for hypochondriasis. Behavioural stress management is also effective but its specificity remains to be demonstrated.

scholarly journals Prevention of Relapse Following Cognitive Therapy vs Medications in Moderate to Severe Depression

2005 ◽  
Vol 62 (4) ◽  
pp. 417 ◽  
Author(s):  
Steven D. Hollon ◽  
Robert J. DeRubeis ◽  
Richard C. Shelton ◽  
Jay D. Amsterdam ◽  
Ronald M. Salomon ◽  
...  
Keyword(s):  
Cognitive Therapy ◽  
Severe Depression ◽  
Prevention Of Relapse

scholarly journals Cognitive Therapy vs Medications in the Treatment of Moderate to Severe Depression

2005 ◽  
Vol 62 (4) ◽  
pp. 409 ◽  
Author(s):  
Robert J. DeRubeis ◽  
Steven D. Hollon ◽  
Jay D. Amsterdam ◽  
Richard C. Shelton ◽  
Paula R. Young ◽  
...  
Keyword(s):  
Cognitive Therapy ◽  
Severe Depression

scholarly journals Comparative Study: Mental Health of Indian Citizens and Indians Overseas

2021 ◽  
Vol 9 (VII) ◽  
pp. 3276-3280
Author(s):  
Sukhmani Bal
Keyword(s):  
Mental Health ◽  
Age Groups ◽  
Severe Depression ◽  
Sample Population ◽  
Anova Analysis ◽  
Moderate Depression ◽  
Significant Difference ◽  
Anxiety Levels ◽  
Severe Anxiety ◽  
Better Than

India is becoming the leading nation of immigrant origin in. Every year many people emigrate from India to other countries. Immigration is not easy and comes with its own troubles and has a profound impact on mental health. The aim of the study was to compare the mental health of Indian citizens and Indians overseas (NRIs and POIs). Samples (N=100) were collected from people living in India, Canada and USA falling in the age group of 21-75years. Two self-rated scales Beck depression inventory and Zung self-rated anxiety scale was used to collect the data. The results show that a total of 23% of the samples were suffering from depression. 16% were dealing with mild mood disturbances, 2% with borderline clinical depression, 3% moderate depression, 1% severe depression and 1% extreme depression as self-rated depression and for anxiety the results show that 27% of the sample population were suffering from anxiety issues. 25% had minimal to moderate anxiety levels and 2% had marked to severe anxiety levels as self-rated anxiety. ANOVA analysis was used to compare the two groups it showed that over all there was no significant difference between the two groups. Although while comparing the population in age groups it was found 21-30year old Indian citizen mental health was better than Indians overseas. No significant difference was found in the age groups 330-50years and 50and above.

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