scholarly journals The burden of gastrointestinal disease: implications for the provision of care in the UK

Gut ◽  
2007 ◽  
Vol 56 (2) ◽  
pp. 165-166 ◽  
Author(s):  
M D Hellier ◽  
J G Williams
2021 ◽  
Vol 12 (2) ◽  
pp. 335-353
Author(s):  
Evette B. M. Hillman ◽  
Sjoerd Rijpkema ◽  
Danielle Carson ◽  
Ramesh P. Arasaradnam ◽  
Elizabeth M. H. Wellington ◽  
...  

Bile acid diarrhoea (BAD) is a widespread gastrointestinal disease that is often misdiagnosed as irritable bowel syndrome and is estimated to affect 1% of the United Kingdom (UK) population alone. BAD is associated with excessive bile acid synthesis secondary to a gastrointestinal or idiopathic disorder (also known as primary BAD). Current licensed treatment in the UK has undesirable effects and has been the same since BAD was first discovered in the 1960s. Bacteria are essential in transforming primary bile acids into secondary bile acids. The profile of an individual’s bile acid pool is central in bile acid homeostasis as bile acids regulate their own synthesis. Therefore, microbiome dysbiosis incurred through changes in diet, stress levels and the introduction of antibiotics may contribute to or be the cause of primary BAD. This literature review focuses on primary BAD, providing an overview of bile acid metabolism, the role of the human gut microbiome in BAD and the potential options for therapeutic intervention in primary BAD through manipulation of the microbiome.


2021 ◽  
Vol 26 (3) ◽  
pp. 20-26
Author(s):  
Vicki Baldrey

Hamsters are popular pets in the UK. The Syrian or Golden hamster (Mesocricetus auratus) is the best known species in the pet trade, with a variety of dwarf species also encountered. Gastrointestinal disease occurs frequently, and diarrhoea is a common presenting complaint. This is most often associated with bacterial or parasitic infection, but can also be related to neoplasia or the use of certain antibiotics. Initial stabilisation of the hamster with diarrhoea should include provision of a warm stress-free environment, fluid therapy, nutritional support with an appropriate critical care diet and analgesia. Following a full history and clinical examination, further diagnostic steps include faecal parasitology and microbiology, routine biochemistry and haematology, radiography with or without positive contrast, and abdominal ultrasound. Indications for surgery include evidence of intestinal obstruction or prolapsed intussusception. This article gives an overview of the most common gastrointestinal diseases encountered in hamster species and provides a guide of how to logically approach the investigation and treatment of these cases, achievable in general practice.


2012 ◽  
Vol 94 (10) ◽  
pp. 338-341 ◽  
Author(s):  
K Butcher ◽  
J Morgan ◽  
S Norton

Obesity rates continue to increase in the UK with nearly 25% of adults now obese and 1–2% morbidly obese. Associated comorbidities include type 2 diabetes, cardiovascular disease, hypertension, increased incidence of cancer and sleep apnoea. These impair quality of life and increase mortality. Furthermore, these illnesses carry a significant cost to the health service and economy, estimated at £3.2 billion in 2007.


2008 ◽  
Vol 18 (4) ◽  
pp. 283-293 ◽  
Author(s):  
Sariqa Wagley ◽  
Kegakilwe Koofhethile ◽  
James B Wing ◽  
Rachel Rangdale

2007 ◽  
Vol 89 (9) ◽  
pp. 327-327
Author(s):  
Paul King

The specialty of restorative dentistry encompasses the monospecialties of endodontics, periodontics and prosthodontics, and involves the provision of care and advice for patients with complex problems associated with restoring satisfactory oral and dental function and aesthetics. Restorative dentistry has been recognised within the UK for nearly 25 years, becoming the third dental specialty along with the pre-existing specialties of oral and maxillofacial surgery and orthodontics in 1973.


2012 ◽  
Vol 3 (3) ◽  
pp. 191-198 ◽  
Author(s):  
John Francis Mayberry ◽  
Affifa Farrukh
Keyword(s):  
The Uk ◽  

2004 ◽  
Vol 8 (37) ◽  
Author(s):  
◽  

An outbreak of gastrointestinal disease on board a cruise ship sailing around Britain is currently being investigated. The MV Mona Lisa left Bremerhaven, northern Germany, on 28 August carrying 940 people


2019 ◽  
Vol 5 (4) ◽  
pp. 292-297 ◽  
Author(s):  
Muhammad Rashid ◽  
Peter F Ludman ◽  
Mamas A Mamas

Abstract The British Cardiovascular Intervention Society (BCIS) percutaneous coronary intervention (PCI) registry is hosted by the National Institute of Cardiovascular Outcomes Research (NICOR) at Bart’s Heart Centre and collects clinical characteristics, indications, procedural details, and outcomes of all patients undergoing PCI in the UK. The data are used for audit and research to monitor and improve PCI practices and patient outcomes. Bespoke live data analysis and structured monthly reports are used to provide real-time feedback to all participating hospitals about the provision of care. Risk-adjusted analyses are used as a quality metric and benchmarking PCI practices. The consecutive patients undergoing PCI in all PCI performing hospitals in the UK from 1994 to present. One hundred and thirteen variables encompassing patient demographics, indication, procedural details, complications, and in-hospital outcomes are recorded. Prospective data are collected electronically and encrypted before transfer to central database servers. Data are validated locally and further range checks, sense checks, and assessments of internal consistency are applied during data uploads. Analyses of uploaded data including an assessment of data completeness are provided to all hospitals for validation, with repeat validation rounds prior to public reporting. Endpoints are in-hospital PCI complications, bleeding and mortality. All-cause mortality is obtained via linkage to the Office of National Statistics. No other linkages are available at present. Available for research by application to NICOR at http://www.nicor.org.uk/ using a data sharing agreement.


2019 ◽  
pp. 171-182
Author(s):  
Sally Ruane

Recent decades, shaped by powerful neoliberal forces, have witnessed a significant encroachment on the UK state sector with privatisation advancing over many social and economic sectors. The extension of private sector involvement has implications for the effective public accountability of UK ‘public’ services. This chapter examines, through case studies drawn from the past ten or fifteen years, selected aspects of this diminished accountability. The three case studies concern the availability of data in relation to different dimensions of privatisation in the NHS: performance data in the provision of care when NHS-funded care is provided by private companies; financial and ownership details in infrastructure procurement; and technical data allowing an assessment of the character and implications of proposals in the policy process.


Dental Update ◽  
2014 ◽  
Vol 41 (7) ◽  
pp. 629-636
Author(s):  
Affifa Farrukh ◽  
Saad Sayeed ◽  
John Mayberry
Keyword(s):  
The Uk ◽  

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