scholarly journals PMO-248 Mucosal upregulation of arachidonic acid production in active ulcerative colitis: delivery of pro-inflammatory eicosanoid precursors

Gut ◽  
2012 ◽  
Vol 61 (Suppl 2) ◽  
pp. A175.3-A176
Author(s):  
D S Pearl ◽  
M Masoodi ◽  
M Eiden ◽  
J Brummer ◽  
D Gullick ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Arachidonic Acid ◽  
Acid Production ◽  
Active Ulcerative Colitis ◽  
Arachidonic Acid Production

scholarly journals Fish Oil in the Treatment of Ulcerative Colitis

1990 ◽  
Vol 4 (7) ◽  
pp. 420-423 ◽  
Author(s):  
C Ó'Moráin ◽  
A Tobin ◽  
T McColl ◽  
Y Suzuki
Keyword(s):  
Ulcerative Colitis ◽  
Arachidonic Acid ◽  
Mechanism Of Action ◽  
Mode Of Action ◽  
Rectal Mucosa ◽  
Leukotriene B4 ◽  
Biologically Active ◽  
Active Ulcerative Colitis ◽  
Pilot Studies ◽  
Lysosomal Membrane Stability

Patients with active ulcerative colitis have increased levels of leukotriene B4 in their rectal mucosa. Eicosapentaenoic acid (EPA) competitively inhibits the cyclo-oxgenase pathway and reduces the formation of cyclo-oxygenase pathway products. EPA is a good substrate for lipoxygenase enzymes and is efficiently converted to leukotriene 85, which is less biologically active. The conversion of EPA to leukotriene B5 is as efficient as that of arachidonic acid to teukotriene B4. Two pilot studies showed benefit of EPA in the treatment of ulcerative colitis. Two of three controlled studies suggest that EPA is more effective than placebo in the treatment of active chronic ulcerative colitis. The mechanism of action is probably reduction of leukotriene B4, but EPA could increase cell and lysosomal membrane stability, or it may exert its effect by reducing interleukin-l. More controlled studies and detailed investigation into the mode of action of EPA are required.

Arachidonic acid production byMortierella sp. S-17 influence of C/N ratio

1990 ◽  
Vol 12 (6) ◽  
pp. 455-456 ◽  
Author(s):  
J. Šajbidor ◽  
S. Dobroñová ◽  
M. Čertík
Keyword(s):  
Arachidonic Acid ◽  
Acid Production ◽  
Arachidonic Acid Production

Arachidonic acid production by the red algaPorphyridium cruentum

1983 ◽  
Vol 25 (4) ◽  
pp. 1057-1070 ◽  
Author(s):  
Tim J. Ahern ◽  
Shigeo Katoh ◽  
Eizo Sada
Keyword(s):  
Arachidonic Acid ◽  
Acid Production ◽  
Arachidonic Acid Production

scholarly journals The Effect of pH and Temperature on Arachidonic Acid Production by Glycerol-Grown Mortierella alpina NRRL-A-10995

Fermentation ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 17 ◽  
Author(s):  
Aleksei Mironov ◽  
Vitaly Nemashkalov ◽  
Nadezda Stepanova ◽  
Svetlana Kamzolova ◽  
Waldemar Rymowicz ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Production ◽  
Mortierella Alpina ◽  
Effect Of Ph ◽  
Arachidonic Acid Production

Arachidonic-acid production by species of Mortierella

1996 ◽  
Vol 12 (1) ◽  
pp. 91-96 ◽  
Author(s):  
V. K. Eroshin ◽  
E. G. Dedyukhina ◽  
T. I. Chistyakova ◽  
V. P. Zhelifonova ◽  
C. P. Kurtzman ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Acid Production ◽  
Arachidonic Acid Production
Sign in / Sign up

Export Citation Format

Share Document