IDDF2018-ABS-0134 Validation of the asia pacific colorectal screening (APCS) score and its modified version in prediction of advanced colorectal neoplasia in chinese asymptomatic subjects

578 Background: Colorectal cancer (CRC) is the third most common cancer in the world. There is strong evidence that screening for colorectal cancer improves survival in conutries with high incidence. Although Mexico is considered a country with a low incidence of CRC, 4694 potentially preventable deaths occur every year. There is no established CRC screening program in our country, risk stratification of the target populations to be screened may bring potential advantages, making the strategy more cost-effective. The Asia-Pacific Colorectal Screening (APCS) score, is a validated risk-stratification tool that helps identify individuals at risk for advanced colorectal neoplasm amongst the asymptomatic population. Methods: We performed a retrospective, cross-sectional analysis of database records from 1172 patients who underwent screening colonoscopy betwen january 2013 and november 2014. Results: The prevalence of advanced colorectal neoplasia was 2.9%. Applying the APCS stratification, 91 subjects (7.8%) were in the average risk tier, 849 subjects (72.4%) in the moderate risk tier and 232 (19.8%) subjects in the high risk tier. The prevalence of advanced neoplasia in the average risk, moderate risk and high risk groups was 0%, 2.6% and 5.1%, respectively. The subjects in the high risk tier had 2.21-fold (p = 0.021) increased prevalence of advanced neoplasia than those in the average-moderate tier. Conclusions: The APCS score is a simple risk stratification index for colorectal advanced neoplasm that uses elementary clinical information on age, gender, family history and smoking to stratify the risk of colorectal advanced neoplasm in asymptomatic subjects for priority of colorectal screening.

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The Performance of Asia-Pacific Colorectal Screenings Score in Predicting Advanced Colorectal Neoplasia in Vietnamese Patients With Lower Bowel Symptoms

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2014.09.014 ◽

2015 ◽

Vol 13 (1) ◽

pp. 216

Author(s):

Duc T. Quach

Keyword(s):

Colorectal Neoplasia ◽

Asia Pacific ◽

Lower Bowel ◽

Bowel Symptoms ◽

Advanced Colorectal Neoplasia

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Validity of APCS score as a risk prediction score for advanced colorectal neoplasia in Chinese asymptomatic subjects

Medicine ◽

10.1097/md.0000000000005123 ◽

2016 ◽

Vol 95 (41) ◽

pp. e5123 ◽

Cited By ~ 7

Author(s):

Wenbin Li ◽

Lili Zhang ◽

Jianyu Hao ◽

Yongdong Wu ◽

Di Lu ◽

...

Keyword(s):

Risk Prediction ◽

Colorectal Neoplasia ◽

Prediction Score ◽

Advanced Colorectal Neoplasia ◽

Asymptomatic Subjects

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Quantitation of faecalFusobacteriumimproves faecal immunochemical test in detecting advanced colorectal neoplasia

Gut ◽

10.1136/gutjnl-2016-312766 ◽

2016 ◽

Vol 66 (8) ◽

pp. 1441-1448 ◽

Cited By ~ 74

Author(s):

Sunny H Wong ◽

Thomas N Y Kwong ◽

Tai-Cheong Chow ◽

Arthur K C Luk ◽

Rudin Z W Dai ◽

...

Keyword(s):

Colorectal Neoplasia ◽

Faecal Immunochemical Test ◽

Advanced Colorectal Neoplasia ◽

Immunochemical Test

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Long-Term Incidence of Advanced Colorectal Neoplasia in Patients with Serrated Polyposis Syndrome: Experience in a Single Academic Centre

Cancers ◽

10.3390/cancers13051066 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1066

Author(s):

Daniel Rodríguez-Alcalde ◽

Guillermo Castillo-López ◽

Jorge López-Vicente ◽

Luis Hernández ◽

Mercedes Lumbreras-Cabrera ◽

...

Keyword(s):

Total Colectomy ◽

Colorectal Neoplasia ◽

Elevated Risk ◽

Advanced Adenoma ◽

Polyposis Syndrome ◽

Serrated Polyp ◽

Advanced Colorectal Neoplasia ◽

Median Interval

Serrated polyposis syndrome (SPS) implies a slightly elevated risk of colorectal cancer (CRC) during endoscopic follow-up, but its natural course is still not well known. The main objective of this study was to describe the long-term risk of developing advanced neoplasia (AN) in these patients. Until October 2020, individuals who fulfilled 2010 WHO criteria I and/or III for SPS were retrospectively recruited. We selected those under endoscopic surveillance after resection of all lesions >3 mm in a high-quality colonoscopy. We excluded patients with total colectomy at diagnosis and those with any interval between colonoscopies >3.5 years. We defined AN as advanced serrated polyp (≥10 mm and/or with dysplasia), advanced adenoma, or CRC. In 109 patients, 342 colonoscopies were performed (median = 3, median interval = 1.8 years) during a median follow-up after colonic clearance of 5.0 years. Five-year cumulative incidences of AN were 21.6% globally, and 5.6%, 10.8%, and 50.8% in patients who fulfilled criterion I, III, and both, respectively (p < 0.001). No CRC was diagnosed and only 1 (0.9%) patient underwent surgery. In conclusion, cumulative incidences of AN could be lower than previously described, at least in patients who fulfil the 2010 WHO criterion III alone. Therefore, low-risk individuals might benefit from less stringent surveillance.

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