scholarly journals Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort

Gut ◽  
2021 ◽  
pp. gutjnl-2021-325701
Author(s):  
Shailja Shah ◽  
Alese Halvorson ◽  
Brandon McBay ◽  
Chad Dorn ◽  
Otis Wilson ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Propensity Score ◽  
Proton Pump ◽  
Weighted Analysis

scholarly journals Proton pump inhibitor use and risk of adverse cardiovascular events in aspirin treated patients with first time myocardial infarction: nationwide propensity score matched study

BMJ ◽  
2011 ◽  
Vol 342 (may11 1) ◽  
pp. d2690-d2690 ◽  
Author(s):  
M. Charlot ◽  
E. L. Grove ◽  
P. R. Hansen ◽  
J. B. Olesen ◽  
O. Ahlehoff ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Proton Pump Inhibitor ◽  
Propensity Score ◽  
Proton Pump ◽  
Cardiovascular Events ◽  
Matched Study ◽  
First Time

scholarly journals Proton pump inhibitor use is not associated with severe COVID-19 related outcomes: A propensity score weighted analysis of a national veteran cohort

2021 ◽  
Author(s):  
Shailja C. Shah ◽  
Alese Halvorson ◽  
Brandon McBay ◽  
Chad Dorn ◽  
Otis Wilson ◽  
...  
Keyword(s):  
Propensity Score ◽  
Proton Pump ◽  
Index Date ◽  
Individual Component ◽  
Composite Outcome ◽  
Logistic Regression Models ◽  
Weighted Analysis ◽  
National Cohort ◽  
Primary Composite Outcome

Background and Aims: Low pH deactivates most pathogens, including coronaviruses. Proton pump inhibitors (PPIs) are potent gastric acid suppressing medications. Whether PPI use vs non-use is associated with severe Coronavirus disease-2019 (COVID-19) outcomes remains uncertain. We aimed to compare severe COVID-19 outcomes between current outpatient PPI users and non-users. Methods: We conducted a retrospective propensity score-weighted analysis of a national cohort of US veterans with established care who tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) through January 9, 2021, and who had 60 days of follow-up. The positive test date was the index date. Current outpatient PPI use up to and including the index date (primary exposure) was compared to non-use, defined as no PPI prescription fill in the 365 days prior to the index date. The primary outcome was a composite of use of mechanical ventilation or death within 60 days. Weighted logistic regression models evaluated severe COVID-19 outcomes between current PPI users vs non-users. Results: Of 97,674 Veterans with SARS-CoV-2 testing, 14,958 tested positive (6262 [41.9%] current PPI users, 8696 [58.1%] non-users) and comprised the analytic cohort. After weighting, all covariates were well-balanced. In the weighted cohort, there was no difference in the primary composite outcome (8.2% vs 8.0%; OR 1.03, 95% CI 0.91-1.16), secondary composite outcome, nor individual component outcomes between current PPI users and non-users. There was no significant interaction between age and PPI use on outcomes. Conclusion: Among patients with SARS-CoV-2 infection, current PPI use vs non-use is not associated with severe COVID-19 outcomes.

scholarly journals Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study

Gut ◽  
2020 ◽  
pp. gutjnl-2020-323668
Author(s):  
Jiandong Zhou ◽  
Xiansong Wang ◽  
Sharen Lee ◽  
William Ka Kei Wu ◽  
Bernard Man Yung Cheung ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Propensity Score ◽  
Proton Pump

Su1811 Propensity Score Matched Analysis of Predictive Factor Associated With Proton Pump Inhibitor-Induced Hypomagnesemia

2013 ◽  
Vol 144 (5) ◽  
pp. S-479 ◽  
Author(s):  
Sunyong Kim ◽  
Chan Hyuk Park ◽  
Choong Nam Shim ◽  
Hyun Jik Lee ◽  
Jun Chul Park ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Propensity Score ◽  
Proton Pump ◽  
Predictive Factor

scholarly journals Risk factors for Clostridium difficile infection in HIV-infected patients

2016 ◽  
Vol 4 ◽  
pp. 205031211668429 ◽  
Author(s):  
Hannah Imlay ◽  
Daniel Kaul ◽  
Krishna Rao
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Proton Pump Inhibitor ◽  
Propensity Score ◽  
Confidence Interval ◽  
Proton Pump ◽  
Clostridium Difficile Infection ◽  
Odds Ratio ◽  
Hospital Admissions ◽  
Cd4 Count

Background: Clostridium difficile infection is a healthcare-associated infection resulting in significant morbidity. Although immunosuppression is associated with Clostridium difficile infection acquisition and adverse outcomes, the epidemiology of Clostridium difficile infection in HIV-infected patients has been little studied in the era of antiretroviral therapy. This study identifies the risk factors for acquisition of Clostridium difficile infection in HIV-infected patients. Methods: A retrospective, propensity score–matched case–control study design was employed, with patients selected from our institution’s outpatient HIV clinic. Clostridium difficile infection cases were defined as having positive stool testing plus an appropriate clinical presentation. The propensity score was generated via multiple logistic regression from year of HIV diagnosis, age at first contact, duration of follow-up, gender, and initial CD4 count. Results: The 46 cases included were matched to a total of 180 controls. Prior antibiotic treatment was a significant predictor of Clostridium difficile infection (odds ratio: 13, 95% confidence interval: 3.49–48.8, p < .001) as was number of hospital admissions in the preceding year (odds ratio: 4.02, confidence interval: 1.81–8.94, p < .001). Having both proton pump inhibitor use and CD4 count <200 cells/µL significantly increased odds of Clostridium difficile infection in the multivariable model (odds ratio: 15.17, confidence interval: 1.31–175.9, p = .021). Conclusion: As in the general population, frequent hospitalizations and exposure to antimicrobials are independent predictors of Clostridium difficile infection acquisition in patients with HIV. Additionally, low CD4 count and proton pump inhibitor use are new potentially modifiable variables that can be targeted for prevention of Clostridium difficile infection in future interventional studies.

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