scholarly journals AT1 receptor antagonists---beyond blood pressure control: possible place in heart failure treatment

Heart ◽  
2000 ◽  
Vol 84 (90001) ◽  
pp. 42i-45 ◽  
Author(s):  
J. McMurray
Author(s):  
Yana Piatetsky ◽  
Matthew Scheidler ◽  
Rachel Garcia ◽  
Mikhail Torosoff

Objective: We investigated the prevalence of blood pressure <130/80 mmHg and studied factors associated with elevated blood pressure in hypertensive ambulatory heart failure patients. Methods: Records of 194 unselected consecutive heart failure patients were reviewed. Demographic and clinical data were collected. ANOVA, chi-square, and logistic regression analyses were used. Results: Systolic blood pressure less than 130 mmHg and diastolic blood pressure less than 80 mmHg was achieved in 52.9% of patients, in 58.4% of men and in 41.6% of women (p=0.076). Patients with diabetes (62%) were more likely to achieve optimal blood pressure (46.4% of patients without diabetes, p=0.033). Age, depressed ejection fraction, body mass index, hemoglobin, creatinine clearance, and histories of dyslipidemia, coronary artery disease, or peripheral vascular disease were not predictive of suboptimal blood pressure control. There was no association between treatment with ACE inhibitors (52.5% of patients with optimal blood pressure vs. 47.8% of patients with suboptimal blood pressure, p=0.517), ARBs (16.8 vs. 15.6%, p=0.811), or beta-blockers (90 vs. 85.6%, p=0.336) and achieving optimal blood pressure. Patients with optimal blood pressure were more likely to have been treated with diuretics (65.3 vs. 50%, p=0.032) or aldosterone receptor antagonists (36.6 vs. 16.7%, p=0.017). Increased use of calcium-channel blockers (CCBs) (12.9 vs. 30%, p=0.003) was noted in patients with suboptimal blood pressure control. Conclusions: Only half of the hypertensive patients with heart failure achieved blood pressure less than 130/80 mmHg, and women were less likely than men to attain optimal blood pressure control. Optimal blood pressure control was more prevalent if the therapeutic regimen included diuretics or aldosterone receptor antagonists. Whether CCBs are used more commonly in patients with elevated blood pressure or whether CCBs are less useful for blood pressure control cannot be established.


2019 ◽  
Vol 21 (8) ◽  
pp. 1132-1134
Author(s):  
Evgeny Belyavskiy ◽  
Elisabeth Pieske‐Kraigher ◽  
Marijana Tadic

1973 ◽  
Vol 1 (7) ◽  
pp. 616-619 ◽  
Author(s):  
P D Nigam ◽  
R Ravishankar ◽  
K A Ramachandren ◽  
P C Sikand

Twenty patients with mild and moderate hypertension were treated with varying doses of propranolol along with hydrochlorothiazide 25 mg daily. In eighteen patients ( 90%) the blood pressure control was good. Bronchospasm, congestive heart failure, significant postural hypotension and other bothersome side-effects were not observed. Propranolol has the merit of causing a slow reduction in blood pressure without troublesome side-effects.


2019 ◽  
Vol 21 (4) ◽  
pp. 451-459
Author(s):  
C. Barrett Bowling ◽  
Barry R. Davis ◽  
Alison Luciano ◽  
Lara M. Simpson ◽  
Richard Sloane ◽  
...  

2007 ◽  
Vol 62 (4) ◽  
pp. 321-328 ◽  
Author(s):  
B. Gremmler ◽  
K. Kisters ◽  
M. Kunet ◽  
H. Schleiting ◽  
L.J. Ulbricht

2019 ◽  
Vol 21 (8) ◽  
pp. 1124-1131 ◽  
Author(s):  
Maria E. Marketou ◽  
Spyros Maragkoudakis ◽  
Kostantinos Fragiadakis ◽  
John Konstantinou ◽  
Alexandros Patrianakos ◽  
...  

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