Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report

2004 ◽  
Vol 14 (1) ◽  
pp. 172-175 ◽  
Author(s):  
A. R. Di Gilio ◽  
G. Cormio ◽  
L. Resta ◽  
C. Carriero ◽  
V. Loizzi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Case Report ◽  
Lymph Node ◽  
Cesarean Section ◽  
Recurrent Disease ◽  
Node Dissection ◽  
Smooth Muscle Tumors ◽  
Vulvar Mass

Smooth muscle tumors arising in the vulva are rare. Leiomyosarcoma is the most common variant of vulvar sarcoma, and very few cases have been reported during pregnancy. A 36-year-old woman presented with a progressively enlarging vulvar mass during pregnancy, diagnosed as a Bartholin's gland cyst. The lesion was resected at 38 weeks of gestation during cesarean section and diagnosis of myxoid leiomyosarcoma of the vulva was made. Six weeks later the patients were referred to our center and submitted to wide vulvar excision with groin lymph node dissection that revealed the presence of a small residual focus of leiomyosarcoma. At 30 months of follow-up the patient was well without any sign of recurrent disease. Leiomyosarcoma should be included in the differential diagnosis of vulvar masses; progressively enlarging vulvar lesion should be biopsied even during pregnancy. Leiomyosarcoma should be considered in the differential diagnosis of vulvar mass.

scholarly journals Stewart–Treves syndrome: a case report

2013 ◽  
Vol 95 (5) ◽  
pp. e6-e8 ◽  
Author(s):  
DG McKeown ◽  
PJ Boland
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Early Treatment ◽  
Radical Mastectomy ◽  
Node Dissection ◽  
Modified Radical Mastectomy ◽  
Patient Death ◽  
Cutaneous Lesions ◽  
Chemotherapeutic Treatment

We present a case of chronic lymphoedema that progressed to Stewart–Treves syndrome in a 63-year-old woman with a previous modified radical mastectomy, associated lymph node dissection, chemotherapy and radiotherapy. While producing stabilisation of most cutaneous lesions initially, chemotherapeutic treatment of the angiosarcoma did not prevent subsequent metastasis and patient death. We urge vigilance and regular follow-up appointments for patients following a mastectomy with chronic lymphoedema to facilitate prevention or early treatment of this devastating syndrome.

Diagnostic accuracy of PET scan in salvage lymph node resections in patients with prostate cancer (CaP).

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 215-215
Author(s):  
David J. K. P. Pfister ◽  
Charlotte Piper ◽  
Daniel Porres ◽  
Theodor Klotz ◽  
Axel Heidenreich
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Lymph Node Dissection ◽  
Recurrent Disease ◽  
Node Dissection ◽  
Pet Ct ◽  
Salvage Lymph Node Dissection ◽  
Node Metastases

215 Background: PET-CT scans in patients with CaP are often used to identify either local recurrent disease or suspected lymph node metastases in early biochemical recurrent disease. The diagnostic accuracy is controversial. We want to show our experience of PET-CT and its diagnostic accuracy in salvage lymph node dissection. Methods: 21 patients treated with radical prostatectomy between 1997 and 2009 presented with PET-CT´s and biochemical recurrent disease and were treated by salvage lymph node dissection to prolong the time to either androgene deprivation or chemotherapy. Diagnostic accuracy was correlated per patient and per lymph nodes. Results: Mean PSA at time of lymph node dissection was 2,73 (0,4-8,4)ng/ml. 17 (81%) received prior radiotherapy and 6 (29%) received androgene deprivation. In total 203 lymph nodes were resected with 58 (29%) harbouring metastasis in 15 (71%) patients. This leads to a Sensitivity, Specifity, positive and negative predictive value of 69%, 12%, 76% and 88% concerning lymph node detection and 70%, 0%, 93% and 0% concerning the calculation per patient. At time of analysis follow-up was available in 5 patients with a biochemical recurrence free survival of 5 (3-12) months. Conclusions: The value of PET-CT in salvage lymph node dissection is under debate and must be questioned according to our results in this setting.

scholarly journals Successful pregnancy after complete resection of leiomyomatosis peritonealis disseminate without recurrence: A case report with next generation sequencing analysis and literature review

2020 ◽  
Author(s):  
Hualei Bu ◽  
Chengjuan Jin ◽  
Yan Fang ◽  
Yana Ma ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cesarean Section ◽  
Sequencing Analysis ◽  
Death Domain ◽  
Uterine Smooth Muscle ◽  
Smooth Muscle Tumors ◽  
Next Generation Sequencing Analysis ◽  
Benign Leiomyoma ◽  
High Level

Abstract Background: Peritoneal leiomyomatosis disseminate (LPD) is a rare disease characterized by widespread dissemination of leiomyomas nodules throughout the peritoneal and omental surfaces. Reports of pregnancy with LPD are even rarer. Therefore, there is no clear consensus on the treatment of LPD on pregnancy, and the pathogenesis is still unclear. Case presentation：We reported a case of LPD patient who developed during pregnancy. The patient underwent cesarean section at 32 weeks of gestation while removing all visible tumors, and no LPD lesions were seen in the subsequently cesarean section at full-term. NGS of LPD lesions detected 4 mutations with focal high-level amplifications of CDK4 (Cyclin-dependent kinases 4), NBN (Nibrin), DAXX (Death domain associated protein) and MYC (Myelocytomatosis oncogene). Immunohistochemistry staining analysis among benign leiomyoma, LPD and leiomyosarcoma verified that LPD was an unusual intermediate between benign and malignant uterine smooth muscle tumors. Besides, LPD is a hormonal-dependent leiomyoma. After detailed literature search, we summarized the detailed clinical features and follow-up information of patients with LPD during pregnancy. Conclusions: This is the first reported LPD case of successful term pregnancy without recurrence, following resection of all visible lesions in prior pregnancy. LPD is an unusual intermediate between benign and malignant uterine smooth muscle tumors.

Conservative Therapy in Microinvasive Adenocarcinoma of the Uterine Cervix is Justified: An Analysis of 59 Cases and a Review of the Literature

2011 ◽  
Vol 21 (9) ◽  
pp. 1640-1645 ◽  
Author(s):  
Astrid Baalbergen ◽  
Frank Smedts ◽  
Theo J.M. Helmerhorst
Keyword(s):  
Lymph Node ◽  
Lymph Node Dissection ◽  
Radical Hysterectomy ◽  
Conservative Therapy ◽  
Recurrent Disease ◽  
Relevant Literature ◽  
Review Of The Literature ◽  
Node Dissection ◽  
Radical Therapy

ObjectiveThis study aimed to evaluate the treatment and follow-up in a large series of women with early cervical adenocarcinoma (AC), stages IA1 and IA2, and to perform an extensive review of the literature in an effort to ascertain whether conservative therapy is justified.MethodsRecords of 59 cases of microinvasive AC diagnosed between 1987 and 2006 in the Rotterdam district, the Netherlands, were retrieved. Clinical and pathological data were reviewed and analyzed. A mesh review of all relevant literature concerning stage IA1 and IA2 was performed.ResultsOf all patients, 33 had stage IA1 and 26 stage IA2 cervical AC. Also, 42 patients were treated conservatively (ie, conization or simple hysterectomy) and 17 patients were treated radically (ie, radical hysterectomy/trachelectomy with lymph node dissection). Recurrence occurred in 1 patient (1.7%) with stage IA1 disease (grade 1 adenocarcinoma, depth 1.4 mm, and width 3.8 mm, with lymph vascular space involvement [LVSI]) treated by vaginal hysterectomy. The mean follow-up was 79.9 months. From the literature, pooling all data from patients with stage IA1 and IA2 AC, the risk of recurrent disease was 1.5% after conservative therapy and 2.0% after radical therapy.ConclusionsExtensive treatment such as radical hysterectomy with pelvic lymph node dissection or trachelectomy does not prevent recurrent disease. Patients with microinvasive AC should be treated identically to patients with SCC. In stage IA1 and IA2 AC, we recommend conservative therapy (by conization). In cases with LVSI, an additional lymphadenectomy is advised. For patients with stage IA2 AC with LVSI, a trachelectomy/radical hysterectomy with lymph node dissection should be considered.

scholarly journals A Rare Case of Synchronous Genital Carcinoma Involving the Endocervix and Bilateral Fallopian Tubes

2011 ◽  
Vol 3 (2) ◽  
pp. 106-108
Author(s):  
Asha Swarup ◽  
RL Manjunath ◽  
HM Sudha
Keyword(s):  
Lymph Node ◽  
Postmenopausal Woman ◽  
Rare Case ◽  
Recurrent Disease ◽  
Papillary Adenocarcinoma ◽  
Pelvic Lymph Node Dissection ◽  
Fallopian Tubes ◽  
Node Dissection ◽  
Unique Condition

ABSTRACT A 53-year-old postmenopausal woman came with profuse watery discharge per vagina and underwent type III radical hysterectomy with pelvic lymph node dissection, as the biopsy from the cervical growth revealed papillary adenocarcinoma. She also received adjuvant combination chemotherapy as it was opined as synchronous genital carcinoma involving the endocervix and bilateral fallopian tubes, which is a rare and unique condition. Patient is on regular follow-up with no evidence of recurrent disease.

scholarly journals Successful pregnancy after complete resection of leiomyomatosis peritonealis disseminate without recurrence:A case report with next generation sequencing analysis and literature review

2020 ◽  
Author(s):  
Hualei Bu ◽  
Chengjuan Jin ◽  
Yan Fang ◽  
Yana Ma ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cesarean Section ◽  
Sequencing Analysis ◽  
Death Domain ◽  
Uterine Smooth Muscle ◽  
Smooth Muscle Tumors ◽  
Next Generation Sequencing Analysis ◽  
Benign Leiomyoma ◽  
High Level

Abstract Background: Peritoneal leiomyomatosis disseminate (LPD) is a rare disease characterized by widespread dissemination of leiomyomas nodules throughout the peritoneal and omental surfaces. Reports of pregnancy with LPD are even rarer. Therefore, there is no clear consensus on the treatment of LPD on pregnancy, and the pathogenesis is still unclear. Case presentation：We reported a case of LPD patient who developed during pregnancy. The patient underwent cesarean section at 32 weeks of gestation while removing all visible tumors, and no LPD lesions were seen in the subsequent cesarean section at full-term. NGS of LPD lesions detected 4 mutations with focal high-level amplifications of CDK4 (Cyclin-dependent kinases 4), NBN (Nibrin), DAXX (Death domain associated protein) and MYC (Myelocytomatosis oncogene). Immunohistochemistry staining analysis among benign leiomyoma, LPD and leiomyosarcoma verified that LPD was an unusual intermediate between benign and malignant uterine smooth muscle tumors. Besides, LPD is a hormonal-dependent leiomyoma. After detailed literature search, we summarized the detailed clinical features and follow-up information of patients with LPD during pregnancy.Conclusions: This is the first reported LPD case of successful term pregnancy without recurrence, following resection of all visible lesions in prior pregnancy. LPD is an unusual intermediate between benign and malignant uterine smooth muscle tumors.

Prostatic Rhabdomyoma in a Toddler: A Case Report With Molecular Characterization

2021 ◽  
pp. 109352662110469
Author(s):  
Paola X. De la Iglesia Niveyro ◽  
J. Pandolfi ◽  
F. Jauk ◽  
T. Kreindel ◽  
P. Lobos
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Case Report ◽  
Next Generation Sequencing ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Ultrasound Evaluation ◽  
Microscopic Evaluation ◽  
Generation Sequencing

We present a 29-month-old male patient in follow-up due to pyelocaliceal dilation with a prostatic nodule incidentally found during ultrasound evaluation. Cysto video endoscopy was performed and a prostate biopsy, obtained. Microscopic evaluation showed a haphazardly distributed population of muscular cells with cross striations without evidence of mitosis or necrosis. Immunohistochemistry was positive for myogenin and desmin and negative for smooth muscle actin. Next generation sequencing was performed without finding any pathogenic variant or fusion in the tumor RNA. The patient received no further treatment, remained asymptomatic and continues in follow up, 3 years after initial diagnosis. We report a case of prostate rhabdomyoma in a toddler, an exceptional location that raises concern about differential diagnosis with its malignant counterpart, rhabdomyosarcoma, especially at this age.

scholarly journals Large intraperitoneal lipoleiomyoma in a pre-menopausal woman: a case report

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Sara L. Schaefer ◽  
Amy L. Strong ◽  
Sheena Bahroloomi ◽  
Jichang Han ◽  
Michella K. Whisman ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Smooth Muscle ◽  
Case Report ◽  
Smooth Muscle Actin ◽  
Abdominal Mass ◽  
Histopathological Analysis ◽  
Menopausal Woman ◽  
En Bloc ◽  
Cross Sectional

Abstract Background Lipoleiomyoma is a rare, benign variant of the commonplace uterine leiomyoma. Unlike leiomyoma, these tumors are composed of smooth muscle cells admixed with mature adipose tissue. While rare, they are most frequently identified in the uterus, but even more infrequently have been described in extrauterine locations. Case presentation We describe a case report of a 45-year-old woman with a history of in vitro fertilization pregnancy presenting 6 years later with abdominal distention and weight loss found to have a 30-cm intra-abdominal lipoleiomyoma. While cross-sectional imaging can narrow the differential diagnosis, histopathological analysis with stains positive for smooth muscle actin, desmin, and estrogen receptor, but negative for HMB-45 confirms the diagnosis of lipoleiomyoma. The large encapsulated tumor was resected en bloc. The patients post-operative course was uneventful and her symptoms resolved. Conclusions Lipoleiomyoma should be considered on the differential diagnosis in a woman with a large intra-abdominal mass. While considered benign, resection should be considered if the mass is symptomatic, and the diagnosis is unclear or there is a concern for malignancy.

Sign in / Sign up

Export Citation Format

Share Document