Expression of cancer stem cell markers is more frequent in anaplastic thyroid carcinoma compared to papillary thyroid carcinoma and is related to adverse clinical outcome

2013 ◽  
Vol 67 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Ji Yun Yun ◽  
Young A Kim ◽  
Ji-Young Choe ◽  
Hyesook Min ◽  
Kyu Sang Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Papillary Thyroid Carcinoma ◽  
Clinical Outcome ◽  
Thyroid Carcinoma ◽  
Cancer Stem Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Stem Cell Markers ◽  
Papillary Thyroid ◽  
Adverse Clinical Outcome ◽  
Cancer Stem Cell Markers

scholarly journals Association of Cancer Stem Cell Markers with Aggressive Tumor Features in Papillary Thyroid Carcinoma

2015 ◽  
Vol 22 (4) ◽  
pp. 508-514 ◽  
Author(s):  
Zhenzhen Lin ◽  
Xuemian Lu ◽  
Weihua Li ◽  
Mengli Sun ◽  
Mengmeng Peng ◽  
...  
Keyword(s):  
Stem Cell ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cancer Stem Cell ◽  
Stem Cell Markers ◽  
Papillary Thyroid ◽  
Cell Markers ◽  
Cancer Stem Cell Markers ◽  
Aggressive Tumor

scholarly journals Rationales for the Use of Cancer Stem Cells Markers in the Staging of Papillary Thyroid Carcinoma

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Noah Abd-Alkader Mahmood ◽  
Amer Talib Tawfeeq ◽  
Israa Mhdi Al-Sudani ◽  
Zaynab Saad Abd-Alghni
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Histopathological Examination ◽  
Standard Procedure ◽  
Tumor Stage ◽  
Needle Aspiration ◽  
Stem Cell Markers ◽  
Papillary Thyroid ◽  
Expression Levels ◽  
Cancer Stem Cell Markers

Fine needle aspiration biopsy (FNAB) is a standard procedure for the detection of thyroid nodules malignancy, yet 10-25% of the sample diagnosed may go undetermined or suspicious. The utility of cancer stem cell markers (CSCM) as a differential diagnosis molecular marker in nodules of suspicious decision in FNAB was hypothesized. Papillary thyroid carcinoma (PTC) and thyroid fibroadenoma (TFA) samples were selected to test the hypothesis. The samples employed in this study were from patients who had thyroid hyperplasia and a suspicious or undetermined diagnosis by FNAB. The patient underwent a successful thyroidectomy at Al-Yarmouk Teaching Hospital in Baghdad between January 2015 and December 2017. All nodule samples underwent a systematic histopathological examination after resection. Tumors diagnosed as PTC and those diagnosed as fibroadenoma (TFA) were selected for this study. Collectively 39 PTC and 11 TFA nodules were included. Quantitative reverse transcriptase real-time PCR (qRT-PCR) and immunohistochemistry (IHC) were used to determine levels of mRNA and proteins of CSCM ALDH1A1, CD44, ABCG2, and Oct3/4 in both types of tumors were used. This study revealed that the expression levels of CSCM were significantly increased in PTC tissues when compared to benign tissues and the positive correlation was found between the CSCM expression levels and tumor stage, size, and gender. In conclusion, for a more precise diagnosis, we suggest these markers be included in what is currently available to characterize malignancy from what is not in thyroid cancer, as well as for the staging process of PTC.

Expression of cancer stem cell markers CD24, EPHA1 and CD9 and their correlation with clinical outcome in epithelial ovarian tumours

2020 ◽  
Vol 28 (3) ◽  
pp. 397-408 ◽  
Author(s):  
Rohit Pravin Nagare ◽  
Smarakan Sneha ◽  
Chirukandath Sidhanth ◽  
S. Roopa ◽  
Kanchan Murhekar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Clinical Outcome ◽  
Cancer Stem Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours

scholarly journals Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/β-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma

2020 ◽  
Vol 11 (9) ◽  
Author(s):  
Wencheng Dai ◽  
Xiaoxia Jin ◽  
Liang Han ◽  
Haijing Huang ◽  
Zhenhua Ji ◽  
...  
Keyword(s):  
Stem Cell ◽  
Papillary Thyroid Carcinoma ◽  
Tumor Microenvironment ◽  
Thyroid Carcinoma ◽  
Cancer Stem Cell ◽  
Migration And Invasion ◽  
Papillary Thyroid ◽  
Potential Target ◽  
Bioinformatics Databases ◽  
Non Coding Rnas

Abstract Exosomal long non-coding RNAs (lncRNAs) are crucial factors that mediate the extracellular communication in tumor microenvironment. DOCK9 antisense RNA2 (DOCK9-AS2) is an exosomal lncRNA which has not been investigated in papillary thyroid carcinoma (PTC). Based on the result of differentially expressed lncRNAs in PTC via bioinformatics databases, we discovered that DOCK9-AS2 was upregulated in PTC, and presented elevation in plasma exosomes of PTC patients. Functionally, DOCK9-AS2 knockdown reduced proliferation, migration, invasion, epithelial-to-mesenchymal (EMT) and stemness in PTC cells. PTC-CSCs transmitted exosomal DOCK9-AS2 to improve stemness of PTC cells. Mechanistically, DOCK9-AS2 interacted with SP1 to induce catenin beta 1 (CTNNB1) transcription and sponged microRNA-1972 (miR-1972) to upregulate CTNNB1, thereby activating Wnt/β-catenin pathway in PTC cells. In conclusion, PTC-CSCs-derived exosomal lncRNA DOCK9-AS2 activated Wnt/β-catenin pathway to aggravate PTC progression, indicating that DOCK9-AS2 was a potential target for therapies in PTC.

The coexistence of anaplastic thyroid carcinoma and papillary thyroid carcinoma: two case reports

2014 ◽  
Author(s):  
Husniye Baser ◽  
Mina Gulfem Kaya ◽  
Sefika Burcak Polat ◽  
Ersin Gurkan Dumlu ◽  
Canan Altunkaya ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Case Reports ◽  
Anaplastic Thyroid Carcinoma ◽  
Papillary Thyroid
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