Critical appraisal of epidemiological studies and clinical trials

2008 ◽  
Vol 62 (3) ◽  
pp. 279-280
Author(s):  
M. A. Martinez-Gonzalez
Keyword(s):  
Clinical Trials ◽  
Critical Appraisal ◽  
Epidemiological Studies

scholarly journals Uric Acid and Hypertension: Prognostic Role and Guide for Treatment

2021 ◽  
Vol 10 (3) ◽  
pp. 448
Author(s):  
Federica Piani ◽  
Arrigo F. G. Cicero ◽  
Claudio Borghi
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Mendelian Randomization ◽  
Strong Association ◽  
Epidemiological Studies ◽  
Hypertensive Disease ◽  
Genetic Studies ◽  
Lowering Therapy ◽  
The Relationship

The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses have found that xanthine oxidoreductase (XOR) genetic polymorphisms are associated with hypertension. However, genetic studies on urate transporters and Mendelian randomization studies failed to demonstrate a causal relationship between SUA and hypertension. Results from clinical trials on the role of urate-lowering therapy in the management of patients with hypertension are not uniform. Our study sought to analyze the prognostic and therapeutic role of SUA in the hypertensive disease, from uric acid (UA) biology to clinical trials on urate-lowering therapies.

A critical appraisal of epidemiological studies investigating the effects of ultrafine particles on human health

2008 ◽  
Vol 18 (3) ◽  
pp. 358-373 ◽  
Author(s):  
Tushyati Maudgalya ◽  
Ash Genaidy ◽  
Gary Weckman ◽  
Richard Shell ◽  
Waldemar Karwowski ◽  
...  
Keyword(s):  
Human Health ◽  
Ultrafine Particles ◽  
Critical Appraisal ◽  
Epidemiological Studies

scholarly journals A systematic literature review and critical appraisal of epidemiological studies on outdoor air pollution and tuberculosis outcomes

2019 ◽  
Vol 170 ◽  
pp. 33-45 ◽  
Author(s):  
Igor Popovic ◽  
Ricardo J. Soares Magalhaes ◽  
Erjia Ge ◽  
Guy B. Marks ◽  
Guang-Hui Dong ◽  
...  
Keyword(s):  
Air Pollution ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Critical Appraisal ◽  
Epidemiological Studies ◽  
Outdoor Air ◽  
Outdoor Air Pollution

scholarly journals Critical appraisal of clinical trials in oncology — part I

2019 ◽  
Vol 15 (2) ◽  
pp. 89-103
Author(s):  
Marcin Kaczor ◽  
Rafał Wójcik ◽  
Joanna Połowinczak-Przybyłek ◽  
Piotr Potemski
Keyword(s):  
Clinical Trials ◽  
Critical Appraisal
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