Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

2018 ◽  
Vol 89 (8) ◽  
pp. 797-803 ◽  
Author(s):  
Anne E Visser ◽  
James P K Rooney ◽  
Fabrizio D’Ovidio ◽  
Henk-Jan Westeneng ◽  
Roel C H Vermeulen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Amyotrophic Lateral Sclerosis ◽  
Positive Association ◽  
Occupational Exposures ◽  
Population Based ◽  
Case Control ◽  
Case Control Studies ◽  
Related Factors ◽  
Logistic Regression Models ◽  
Lateral Sclerosis

ObjectiveTo investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case–control studies in three European countries using a validated and harmonised questionnaire.MethodsPatients with incident ALS and controls were recruited from five population-based registers in The Netherlands, Ireland and Italy. Demographic and data regarding educational level, smoking, alcohol habits and lifetime PA levels in both leisure and work time were gathered by questionnaire, and quantified using metabolic equivalent of task scores. Logistic regression models adjusting for PA-related factors were used to determine the association between PA and ALS risk, and forest plots were used to visualise heterogeneity between regions.Results1557 patients and 2922 controls were included. We found a linear association between ALS and PA in leisure time (OR 1.07, P=0.01) and occupational activities (OR 1.06, P<0.001), and all activities combined (OR 1.06, P<0.001), with some heterogeneity between regions: the most evident association was seen in the Irish and Italian cohorts. After adjustment for other occupational exposures or exclusion of patients with a C9orf72 mutation, the ORs remained similar.ConclusionWe provide new class I evidence for a positive association between PA and risk of ALS in a large multicentre study using harmonised methodology to objectively quantify PA levels, with some suggestions for population differences.

Physical activity and amyotrophic lateral sclerosis: A European population-based case-control study

2014 ◽  
Vol 75 (5) ◽  
pp. 708-716 ◽  
Author(s):  
Elisabetta Pupillo ◽  
Paolo Messina ◽  
Giorgia Giussani ◽  
Giancarlo Logroscino ◽  
Stefano Zoccolella ◽  
...  
Keyword(s):  
Physical Activity ◽  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
European Population ◽  
Control Study ◽  
Lateral Sclerosis

scholarly journals Occupational Exposures and Amyotrophic Lateral Sclerosis. A Population-based Case-Control Study

1997 ◽  
Vol 145 (12) ◽  
pp. 1076-1088 ◽  
Author(s):  
V. McGuire ◽  
W. T. Longstreth ◽  
L. M. Nelson ◽  
T. D. Koepsell ◽  
H. Checkoway ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Population Based ◽  
Case Control ◽  
Control Study ◽  
Lateral Sclerosis

scholarly journals Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

2020 ◽  
Vol 17 (8) ◽  
pp. 2882 ◽  
Author(s):  
Tommaso Filippini ◽  
Marina Tesauro ◽  
Maria Fiore ◽  
Carlotta Malagoli ◽  
Michela Consonni ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Environmental Exposure ◽  
Case Control Study ◽  
Positive Association ◽  
Population Based ◽  
Case Control ◽  
Occupational Factors ◽  
Increased Risk ◽  
Control Study ◽  
Lateral Sclerosis

Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with still unknown etiology. We aimed at investigating the association between environmental and occupational factors with ALS risk. Methods: We performed a population-based case-control study in four Italian provinces (Catania, Modena, Novara, and Reggio Emilia) by administration of tailored questionnaires to ALS cases (n = 95) and randomly selected population referents (n = 135). We estimated ALS risk by calculating the odds ratio (OR) with its 95% confidence interval (CI) using an unconditional logistic regression model. Results: We found a positive association with disease risk for history of occupation in the agricultural sector (OR = 2.09, 95% CI 0.79–7.54), especially for longer than 10 years (OR = 2.72, 95% 1.02–7.20). Overall occupational exposure to solvents also suggested a positive association, especially for thinners (OR = 2.27, 95% CI 1.14–4.54) and paint removers (OR = 2.01, 95% CI 0.90–4.48). Both occupational and environmental exposure to electromagnetic fields show a slightly increased risk with OR = 1.69 (95% CI 0.70–4.09) and 2.41 (95% CI 1.13–5.12), respectively. Occupational but not environmental exposure to pesticides (OR = 1.22, 95% CI 0.63–2.37), particularly fungicides, and exposure to metals (OR = 4.20, 95% CI 1.88–9.38), particularly lead, mercury, and selenium, showed an imprecise but positive association. Finally, there was an indication of increased risk for living in proximity to water bodies. Conclusions: Despite the caution that needs to be used due to some study limitations, such as the low number of exposed subjects and the possibility of recall bias, these results suggest the potential role of some environmental and occupational factors in ALS etiology.

scholarly journals Multicentre, population-based, case–control study of particulates, combustion products and amyotrophic lateral sclerosis risk

2019 ◽  
Vol 90 (8) ◽  
pp. 854-860 ◽  
Author(s):  
Anne E Visser ◽  
Fabrizio D'Ovidio ◽  
Susan Peters ◽  
Roel CH Vermeulen ◽  
Ettore Beghi ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Occupational Exposures ◽  
Combustion Products ◽  
Population Based ◽  
Case Control ◽  
Organic Dust ◽  
Control Study ◽  
Lateral Sclerosis ◽  
Motor Exhaust

ObjectiveTo investigate whether exposure to particulates and combustion products may explain the association between certain occupations and amyotrophic lateral sclerosis (ALS) risk in a large, multicentre, population-based, case–control study, based on full job histories, using job-exposure matrices, with detailed information on possible confounders.MethodsPopulation-based patients with ALS and controls were recruited from five registries in the Netherlands, Ireland and Italy. Demographics and data regarding educational level, smoking, alcohol habits and lifetime occupational history were obtained using a validated questionnaire. Using job-exposure matrices, we assessed occupational exposure to silica, asbestos, organic dust, contact with animals or fresh animal products, endotoxins, polycyclic aromatic hydrocarbons and diesel motor exhaust. Multivariate logistic regression models adjusting for confounding factors were used to determine the association between these exposures and ALS risk.ResultsWe included 1557 patients and 2922 controls. Associations were positive for all seven occupational exposures (ORs ranging from 1.13 to 1.73 for high vs never exposed), and significant on the continuous scale for silica, organic dust and diesel motor exhaust (p values for trend ≤0.03). Additional analyses, adding an exposure (one at a time) to the model in the single exposure analysis, revealed a stable OR for silica. We found similar results when patients with a C9orf72 mutation were excluded.ConclusionIn a large, multicentre study, using harmonised methodology to objectively quantify occupational exposure to particulates and combustion products, we found an association between ALS risk and exposure to silica, independent of the other occupational exposures studied.

scholarly journals Study of occupation and amyotrophic lateral sclerosis in a Danish cohort

2018 ◽  
Vol 75 (9) ◽  
pp. 630-638 ◽  
Author(s):  
Aisha S Dickerson ◽  
Johnni Hansen ◽  
Marianthi-Anna Kioumourtzoglou ◽  
Aaron J Specht ◽  
Ole Gredal ◽  
...  
Keyword(s):  
Physical Activity ◽  
Amyotrophic Lateral Sclerosis ◽  
Conditional Logistic Regression ◽  
Demographic Data ◽  
Physical Exertion ◽  
Positive Association ◽  
Logistic Regression Models ◽  
Danish Cohort ◽  
Using Data ◽  
Lateral Sclerosis

ObjectivesSeveral manuscripts have proposed associations between amyotrophic lateral sclerosis (ALS) and occupational toxicant exposures—not to mention physical activity and trauma/injury. Some have also reported associations in investigations of specific occupations. Using data from a prospective Danish cohort study, we investigated the association between employment in certain industries and ALS diagnosis.MethodsWe identified 1826 ALS cases who were 25 years old or less in 1964 and diagnosed from 1982 to 2013 from the Danish National Patient Registry then matched 100 population controls to each case based on birth year and sex. Demographic data were linked to the Danish Pension Fund to determine occupation history. Conditional logistic regression models were adjusted for socioeconomic status, marital status and residential location at the index date.ResultsThere was an increase in odds of ALS among men who worked in agriculture, hunting, forestry or fishing (adjusted OR (aOR)=1.21; 95% CI 1.02 to 1.45). There was also a positive association for men employed in construction (aOR=1.21; 95% CI 1.05 to 1.39). In women, a protective association was seen with employment in the cleaning industry (aOR=0.69; 95% CI 0.52 to 0.93).ConclusionsOur study shows various occupations with exposure to toxicants, such as diesel exhaust and lead, and strenuous physical activity associated with increased odds of ALS in men. Future studies should have a particular focus on gathering detailed information on physical exertion and toxicant exposures specific to certain job tasks.

scholarly journals Trauma and amyotrophic lateral sclerosis: a case-control study from a population-based registry

2012 ◽  
Vol 19 (12) ◽  
pp. 1509-1517 ◽  
Author(s):  
E. Pupillo ◽  
P. Messina ◽  
G. Logroscino ◽  
S. Zoccolella ◽  
A. Chiò ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Population Based Registry ◽  
Control Study ◽  
Lateral Sclerosis

Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case–control study

2015 ◽  
Vol 359 (1-2) ◽  
pp. 11-17 ◽  
Author(s):  
Beatrice Bocca ◽  
Giovanni Forte ◽  
Riccardo Oggiano ◽  
Simonetta Clemente ◽  
Yolande Asara ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study ◽  
Lateral Sclerosis

Environmental Exposure to Trace Elements and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case–Control Study

2002 ◽  
Vol 89 (2) ◽  
pp. 116-123 ◽  
Author(s):  
Margherita Bergomi ◽  
Marco Vinceti ◽  
Grazia Nacci ◽  
Vladimiro Pietrini ◽  
Peter Brätter ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Trace Elements ◽  
Environmental Exposure ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study ◽  
Lateral Sclerosis

scholarly journals Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

2020 ◽  
Vol 17 (3) ◽  
pp. 857 ◽  
Author(s):  
Tommaso Filippini ◽  
Maria Fiore ◽  
Marina Tesauro ◽  
Carlotta Malagoli ◽  
Michela Consonni ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Case Control Study ◽  
Southern Italy ◽  
Population Based ◽  
Case Control ◽  
Lifestyle Factors ◽  
Inverse Association ◽  
Increased Risk ◽  
Control Study ◽  
Lateral Sclerosis

Background: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease of the motor neurons. The etiology of ALS remains largely unknown, particularly with reference to the potential environmental determinants. Methods: We performed a population-based case-control study in four provinces from both Northern and Southern Italy in order to assess non-genetic ALS risk factors by collecting through tailored questionnaires information about clinical and lifestyle factors. We estimated ALS risk by calculating odds ratio (OR) with its 95% confidence interval (CI) using unconditional logistic regression models adjusted for sex, age and educational attainment. Results: We recruited 230 participants (95 cases and 135 controls). We found a possible positive association of ALS risk with trauma, particularly head trauma (OR = 2.61, 95% CI 1.19–5.72), electric shock (OR = 2.09, 95% CI 0.62–7.06), and some sports, although at a competitive level only. In addition, our results suggest an increased risk for subjects reporting use of private wells for drinking water (OR = 1.38, 95% CI 0.73–2.27) and for use of herbicides during gardening (OR = 1.95, 95% CI 0.88–2.27). Conversely, there was a suggestion of an inverse association with overall fish consumption (OR = 0.27, 95% CI 0.12–0.60), but with no dose-response relation. Consumption of some dietary supplements, namely those containing amino acids and, in the Southern Italy population, vitamins and minerals such as selenium, seemed associated with a statistically imprecise increased risk. Conclusions: Our results suggest a potential etiologic role a number of clinical and lifestyle factors with ALS risk. However, caution is needed due to some study limitations. These include the small sample size and the low number of exposed subjects, which affect statistical precision of risk estimates, the potential for exposure misclassification, and the uncertainties about mechanisms underpinning the possible association between these factors and disease risk.

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