094 Towards objective testing in parkinson’s disease: a systematic review of the literature looking at assessment of postural sway

IntroductionParkinson’s Disease (PD) is associated with increased mortality and reduced quality of life. There is currently no accurate objective measure for use in diagnosis or assessment of severity. Analysis of postural sway may help in this regard. This systematic review aimed to assess the effectiveness of the various features currently used to analyse postural sway.MethodsFive databases were searched for articles that examined postural sway in both PD patients and controls. An effect size (ES) was derived for every feature reported in each article. The most effective features and feature-families were determined, along with the influence on these measures of data sampling rate and experimental condition.Results441 papers were initially retrieved, of which 31 met the requirements for analysis. The most commonly-used features were not the most effective (e.g. PathLength had an ES of 0.47 while TotalEnergy had an ES of 1.78). Decreased sampling rate was associated with decreased ES (e.g. ES of PathLength lowered from 1.12 at 100 Hz to 0.40 at 10 Hz). Being off medication was associated with a larger ES (e.g. ES of PathLength was 0.21 on medication and 0.83 off medication).ConclusionsSome measures of postural sway are better able to distinguish PD patients from controls than others. ES is enhanced by using a higher sampling rate and studying patients off medication. These results will inform future studies looking at postural sway in PD and contribute to the aim of finding an objective marker of the disease.

Download Full-text

Systematic Review of Postural Sway Features in Parkinson's Disease Classification (Preprint)

10.2196/preprints.13988 ◽

2019 ◽

Author(s):

Wenbo Ge ◽

Christian J. Lueck ◽

Deborah Apthorp ◽

Hanna Suominen

Keyword(s):

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Effect Size ◽

Postural Sway ◽

Sampling Rate ◽

Disease Classification ◽

Clinical State ◽

Future Research ◽

Online Databases

BACKGROUND Parkinson’s Disease (PD) is the second most prevalent neurodegenerative disease. It is associated with impaired quality of life, reduced working capacity, and increased mortality. Current diagnosis and tracking lacks objectivity, resulting in late diagnosis and suboptimal treatment. OBJECTIVE Our objective is to review the existing literature to 1) assess the effectiveness of features currently being used and determine if any refinements may increase feature effectiveness, and 2) provide a summary of current methods being used. METHODS A systematic review of the literature, searching 5 online databases. An Effect Size (ES) was derived for every feature reported in each article. Effect size were combined over several articles by averaging and by pooling. The effect of sampling rate and clinical state on ES were also assessed. RESULTS 443 papers were found, reduced to 31 after review. 25 of these contained enough information to derive effect sizes. The most common features were not the most effective, that there was a relationship between sampling rate and ES, assessment when off medication best distinguished patients from controls. CONCLUSIONS This review identifies the optimal features when measuring postural sway, including sampling rate, and clinical state, to maximize ES when trying to distinguish patients with PD from controls. The findings will influence future research and assist in developing a more objective tool for the assessment of PD.

Download Full-text

Quality of life in Parkinson's disease: A systematic review and meta‐analysis of comparative studies

CNS Neuroscience & Therapeutics ◽

10.1111/cns.13549 ◽

2020 ◽

Author(s):

Na Zhao ◽

Yuan Yang ◽

Ling Zhang ◽

Qinge Zhang ◽

Lloyd Balbuena ◽

...

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Comparative Studies ◽

Meta Analysis

Download Full-text

Decision letter for "Which features of postural sway are effective in distinguishing Parkinson's disease from controls? A systematic review"

10.1002/brb3.1929/v2/decision1 ◽

2020 ◽

Keyword(s):

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Postural Sway

Download Full-text

Decision letter for "Which features of postural sway are effective in distinguishing Parkinson's disease from controls? A systematic review"

10.1002/brb3.1929/v1/decision1 ◽

2020 ◽

Keyword(s):

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Postural Sway

Download Full-text

Wearable Solutions for Patients with Parkinson’s Disease and Neurocognitive Disorder: A Systematic Review

Sensors ◽

10.3390/s20092713 ◽

2020 ◽

Vol 20 (9) ◽

pp. 2713 ◽

Cited By ~ 5

Author(s):

Asma Channa ◽

Nirvana Popescu ◽

Vlad Ciobanu

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Positive Impact ◽

Wearable Devices ◽

Neurocognitive Disorder ◽

Research Findings ◽

Early Diagnose

Prevalence of neurocognitive diseases in adult patients demands the use of wearable devices to transform the future of mental health. Recent development in wearable technology proclaimed its use in diagnosis, rehabilitation, assessment, and monitoring. This systematic review presents the state of the art of wearables used by Parkinson’s disease (PD) patients or the patients who are going through a neurocognitive disorder. This article is based on PRISMA guidelines, and the literature is searched between January 2009 to January 2020 analyzing four databases: PubMed, IEEE Xplorer, Elsevier, and ISI Web of Science. For further validity of articles, a new PEDro-inspired technique is implemented. In PEDro, five statistical indicators were set to classify relevant articles and later the citations were also considered to make strong assessment of relevant articles. This led to 46 articles that met inclusion criteria. Based on them, this systematic review examines different types of wearable devices, essential in improving early diagnose and monitoring, emphasizing their role in improving the quality of life, differentiating the various fitness and gait wearable-based exercises and their impact on the regression of disease and on the motor diagnosis tests and finally addressing the available wearable insoles and their role in rehabilitation. The research findings proved that sensor based wearable devices, and specially instrumented insoles, help not only in monitoring and diagnosis but also in tracking numerous exercises and their positive impact towards the improvement of quality of life among different Parkinson and neurocognitive patients.

Download Full-text