Abstract: without Background and including Keywords: 251/275 wordsBackground: There are no disease specific theoretical models describing dysfunction in Snakebite Envenoming (SBE). The International Classification of Functioning, Disability, and Health (ICF) created by the WHO provides a conceptual basis for defining all aspects of functioning and disability within the biopsychosocial model. The Patient-Specific Functional Scale (PSFS) is a patient-centered and patient-reported outcome that assesses activities chosen by the patient as limiting and important. Objective: In this study, we analyze the PSFS activities in SBE and apply it to the existing ICF model in order to describe the impact of SBE in patients’ activities and daily lives’ that goes beyond the description of the physiological effects and to develop a theoretical SBE model of functioning. Design: This study performed a post-hoc analysis of two multi-center, prospective studies, conducted at 14 clinical sites across the southeastern United States. Participants: Patients undergoing treatment for mild, moderate and severe SBE.Main outcome measures: Activities listed in the PSFS were used for a combination of qualitative content analysis and Natural Language Processing to categorize responses using the ICF model.Results: Our sample included 86 patients. The mean age was 43.0 (SD 17.6) years, most had lower extremity injuries (62%). A total of 99 unique activities were chosen by patients when completing the PSFS, representing eight of the nine domains within the Activity and Participation component of the ICF model, with the majority in the Mobility and General Tasks and Demands domains.Conclusion: The main concerns of SBE patients are related to the ability to perform regular daily activities and to engage within their social environment, having a multifaceted impact in a variety of areas in their daily lives. Applying the ICF model to SBE can facilitate the creation of a patient centered treatment approach, moving beyond body-structural impairments towards a function-based treatment approach and facilitate early integration of rehabilitation services. Keywords: Snakebite envenoming, snake bite, PSFS, ICF, Function, Disability