A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis

Introduction Although previous studies have suggested associations between serum intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25(OH)D) and metabolic syndrome (MS) in the general population, these associations are still uncharacterized in peritoneal dialysis (PD) patients. Methods In total, 837 prevalent PD patients from 5 centers in China were enrolled between April 1, 2011 and November 1, 2011. The demographic data, biochemical parameters and medical records were collected, except for serum 25(OH)D which was measured in 347 of 837 patients. The definition of MS was modified from National Cholesterol Education Program Third Adult Treatment Panel (NCEP-ATPIII). Results 55.4% of 837 patients were found to have MS. The median concentration of iPTH, 25(OH)D and doses of oral vitamin D analogs for participants with MS was significantly lower than those without MS. The iPTH, 25(OH)D values and doses of vitamin D analogs were all associated with one or more components of MS. After multivariate adjustment, Low serum iPTH values and oral vitamin D analogs, rather than serum 25(OH)D, were significantly associated with the presence of MS, abnormal fasting blood glucose (FBG) and high-density lipoprotein cholesterol (HDL-C). Compared to iPTH < 130pg/mL, iPTH 130–585 pg/mL and > 585pg/mL were associated with a lower risk of MS with adjusted odds ratio (OR) of 0.59 and 0.33, respectively. Taking vitamin D analogs was also associated with a lower risk of MS with adjusted OR of 0.55. Conclusions Serum iPTH and the use of active vitamin D supplements rather than serum 25(OH)D were independently associated with the presence of MS in patients on PD.

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Vitamin D supply among healthy blood donors in County Vas, Hungary

Orvosi Hetilap ◽

10.1556/oh.2012.29459 ◽

2012 ◽

Vol 153 (41) ◽

pp. 1629-1637 ◽

Cited By ~ 4

Author(s):

Éva Virágh ◽

Dóra Horváth ◽

Zoltán Lőcsei ◽

László Kovács ◽

Rita Jáger ◽

...

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Oral Contraceptives ◽

Blood Donors ◽

Elderly Subjects ◽

Intact Parathyroid Hormone ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Impact

Introduction: There is growing evidence showing the importance of adequate vitamin D supply for preserving health. Aim: The aim of the study was to evaluate the vitamin D supply among healthy blood donors and healthy elderly subjects in County Vas, Hungary. Methods: Serum 25-hydroxyvitamin D, intact parathyroid hormone, calcium and albumin (Cobas, Modular, Roche), as well as serum alfa-2-globulin concentrations (Gelelfo, Interlab) were determined in 178 serum samples (68 men, 110 women, 41 were taking oral contraceptives). The results were analysed according to sex and age (younger and older than 43 years), and the impact of oral contraceptive use was also taken into consideration. Results: Deficiency and insufficiency in vitamin D levels were detected in 9.6% and 32% of the studied subjects, respectively, whereas sufficient vitamin D levels were present in 58.4% of the subjects. 63% of the older and 41.2% of the younger group had suboptimal vitamin-D supply (p < 0.01). In women taking oral contraceptives serum 25-hydroxyvitamin D and alfa-2-globulin levels were significantly higher, whereas serum albumin and calcium levels were lower than in the control group. There was no difference in serum intact parathyroid hormone concentration between oral anticoncipient users and non-users. Conclusions: The occurrence of suboptimal vitamin D supply is significant, although less frequent than that in literature reports. In women taking oral contraceptives, serum 25-hydroxyvitamin D levels were higher, but serum intact parathyroid hormone concentrations were not decreased suggesting that the increased 25-hydroxyvitamin D levels may be the consequence of oestrogen-induced alterations of serum protein fractions. Orv. Hetil., 2012, 153, 1629–1637.

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Study on the Relationship of 25-hydroxyvitamin D and Intact Parathyroid Hormone in Chinese Adults

10.21203/rs.2.21603/v1 ◽

2020 ◽

Author(s):

Yichun Hu ◽

Siran Li ◽

Zhen Liu ◽

Lichen Yang ◽

Xiaoguang Yang

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Intact Parathyroid Hormone ◽

Chinese Adults ◽

Serum Samples ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Relationship Of ◽

The Relationship ◽

Ipth Concentration

Abstract Background:Vitamin D plays an important role in bone health and other diseases, however, there is no consensus over the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration. Many studies consider that the 25(OH)D concerntration which maximally inhibit serum intact parathyroid hormone (iPTH) might be the optimal status for vitamin D sufficiency. This study was performed to study the relationship between 25(OH)D concentration and intact parathyroid hormone (iPTH) concentration in the Chinese non-clinical population aged 18-44y. Methods: The serum samples of adults aged 18-44 years old were selected from the established serum bank of Chinese Chronic Diseases and Nutrition Survey (CCDNS, 2015-2018). The serum 25(OH)D concentration was determined by high performance liquid chromatography tandem mass spectrometer, and the iPTH was determined by electronic chemiluminescence method. The relationship of 25(OH)D and iPTH were analyzed by correlation analysis, segmented linear regression and the confidence interval was determined by bootstrap method. Results: 623 serum samples (293 male, 330 female) of 25(OH)D concentration and iPTH concentration were analyzed. Significant higher 25(OH)D concentration was found in male than female. And the samples from the southern China had higher 25(OH)D concentration than those from the northern China. Samples from autumn had higher 25(OH)D concentration than those from spring and winter. The inversely relationship between 25(OH)D concentration and iPTH concentration was observed in both male and female. The concentration of 25(OH)D was 19.2 (10.1-27.2) ng/mL (P=0.02) when iPTH entered the plateau in women and no plateau for iPTH was found in men. Conclusions: The relationship between 25(OH)D and iPTH differs by sex among Chinese adults aged 18-44y. Further study is needed to evaluate the sex-specific ranges of optimal vitamin D. Trial registration: Not applicable. Keywords: 25-hydroxyvitamin D; parathyroid hormone; plateau; Chinese adults

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Dietary Intake of Vitamin D in Premenopausal, Healthy Vegans was Insufficient to Maintain Concentrations of Serum 25-hydroxyvitamin D and Intact Parathyroid Hormone Within Normal Ranges During the Winter in Finland

Journal of the American Dietetic Association ◽

10.1016/s0002-8223(00)00134-6 ◽

2000 ◽

Vol 100 (4) ◽

pp. 434-441 ◽

Cited By ~ 57

Author(s):

TERHI AULIKKI OUTILA ◽

MERJA ULLA MARGAREETTA KÄRKKÄINEN ◽

RIITTA HELENA SEPPÄNEN ◽

CHRISTEL JOHANNA EMILIA LAMBERG-ALLARDT

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Dietary Intake ◽

Intact Parathyroid Hormone ◽

Hydroxyvitamin D ◽

Normal Ranges ◽

25 Hydroxyvitamin D

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Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-004-0553-8 ◽

2005 ◽

Vol 23 (2) ◽

pp. 147-151 ◽

Cited By ~ 48

Author(s):

Yasunaga Ono ◽

Atsushi Suzuki ◽

Motoko Kotake ◽

Xiaoli Zhang ◽

Keiko Nishiwaki-Yasuda ◽

...

Keyword(s):

Parathyroid Hormone ◽

Seasonal Changes ◽

Japanese Population ◽

Intact Parathyroid Hormone ◽

Hormone Levels ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Normal Japanese

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Vitamin D-Dependent Rickets Type 1: A Rare, but Treatable, Cause of Severe Hypotonia in Infancy

Journal of Child Neurology ◽

10.1177/0883073811411190 ◽

2011 ◽

Vol 26 (12) ◽

pp. 1571-1575 ◽

Cited By ~ 7

Author(s):

Yun Yan ◽

Ali S. Calikoglu ◽

Nina Jain

Keyword(s):

Vitamin D ◽

Alkaline Phosphatase ◽

Parathyroid Hormone ◽

Tubular Dysfunction ◽

Exon 2 ◽

Hormone Levels ◽

Hydroxyvitamin D ◽

Severe Hypotonia ◽

25 Hydroxyvitamin D

Vitamin D-dependent rickets type 1 is an autosomal recessive disorder caused by an inactivating mutation of the 25-hydroxyvitamin-D-1α-hydroxylase (CYP27B1) gene. Clinical presentation is characterized by early onset of severe rickets and can include severe hypotonia. Here, we report a 16-month-old white male who presented with severe muscle weakness, failure to thrive, renal tubular dysfunction, and skeletal deformities, including osteopenia and multiple fractures. At presentation, he had severe hypocalcemia, hypophosphatemia, hypomagnesemia, and elevated alkaline phosphatase and parathyroid hormone levels, although normal 25-hydroxyvitamin D levels. DNA sequencing of the CYP27B1 gene revealed a novel mutation in exon 2 (c286_300de115) and a previously reported mutation in exon 7 (c.1166G>A). Once calcitriol therapy was initiated, the patient showed significant improvement in muscle strength and linear growth. Serum calcium, phosphorous, and alkaline phosphatase returned to normal range. Organic aciduria resolved and aminoaciduria significantly improved 2 months after parathyroid hormone levels normalized.

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