No evidence of JC virus reactivation in natalizumab treated multiple sclerosis patients: an 18 month follow-up study

2010 ◽  
Vol 81 (12) ◽  
pp. 1345-1350 ◽  
Author(s):  
L. Rinaldi ◽  
F. Rinaldi ◽  
P. Perini ◽  
M. Calabrese ◽  
D. Seppi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Jc Virus ◽  
Virus Reactivation ◽  
Follow Up Study ◽  
Multiple Sclerosis Patients

scholarly journals Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study

2014 ◽  
Vol 85 (10) ◽  
pp. 1109-1115 ◽  
Author(s):  
Cecilie Jacobsen ◽  
Jesper Hagemeier ◽  
Kjell-Morten Myhr ◽  
Harald Nyland ◽  
Kirsten Lode ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Disability Progression ◽  
Follow Up Study ◽  
Multiple Sclerosis Patients

The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study

2007 ◽  
Vol 13 (8) ◽  
pp. 1068-1070 ◽  
Author(s):  
L. Roccatagliata ◽  
MA Rocca ◽  
P. Valsasina ◽  
L. Bonzano ◽  
MP Sormani ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Marked Decrease ◽  
Hematopoietic Stem ◽  
Follow Up Study ◽  
Long Term Effect ◽  
Second Year ◽  
Multiple Sclerosis Patients

Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment. Multiple Sclerosis 2007; 13 : 1068—1070. http://msj.sagepub.com

Cognitive impairment in newly diagnosed multiple sclerosis patients: A 4-year follow-up study

2006 ◽  
Vol 245 (1-2) ◽  
pp. 77-85 ◽  
Author(s):  
Agnete Jønsson ◽  
Jente Andresen ◽  
Lars Storr ◽  
Thomas Tscherning ◽  
Per Soelberg Sørensen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Newly Diagnosed ◽  
Follow Up Study ◽  
Multiple Sclerosis Patients

Natalizumab modulates the humoral response against HERV-Wenv73–88 in a follow-up study of Multiple Sclerosis patients

2015 ◽  
Vol 357 (1-2) ◽  
pp. 106-108 ◽  
Author(s):  
Giannina Arru ◽  
Elisa Caggiu ◽  
Stefania Leoni ◽  
Giuseppe Mameli ◽  
Maura Pugliatti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Humoral Response ◽  
Follow Up Study ◽  
Multiple Sclerosis Patients

JC virus in cerebrospinal fluid samples of multiple sclerosis patients at the first demyelinating event

2007 ◽  
Vol 13 (5) ◽  
pp. 590-595 ◽  
Author(s):  
Roberto Alvarez-Lafuente ◽  
Marta García-Montojo ◽  
Virginia De Las Heras ◽  
Manuel Bartolomé ◽  
Rafael Arroyo
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Jc Virus ◽  
Neurological Diseases ◽  
Positive Sample ◽  
Viral Loads ◽  
Immunological Activation ◽  
Viral Particles ◽  
Multiple Sclerosis Patients

Objective To evaluate the possible involvement of JC virus (JCV) in the aetiology of multiple sclerosis (MS), through the comparison of DNA prevalences and viral loads of JCV in cerebrospinal fluid (CSF) of MS patients at the first demyelinating event and subjects suffering from other neurological diseases (OND). Methods Seventy-three CSF samples (43 from MS patients at the first demyelinating event, and 30 from patients with OND) were collected; all MS cases were followed up from 1 to 6.7 years after they were diagnosed with clinically definite MS. DNA was extracted and analysed by real-time PCR for the detection of JCV genomes. Results We found JCV DNA in the CSF of two MS patients (4.7%) with a mean viral load of 2.1 and 6.7 copies/mL of CSF. Among the patients of the OND group we did not find any positive sample. We did not find any difference in the course of the disease between MS patients with and without JCV genomes in their CSF along the follow up. Conclusion JCV seems to be only a bystander in the pathology of MS, and the presence of cell-free viral particles could be related to the immunological activation of the disease, mainly during relapses. Multiple Sclerosis 2007; 13: 590-595. http://msj.sagepub.com

Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients

2000 ◽  
Vol 6 (6) ◽  
pp. 373-377 ◽  
Author(s):  
E. Fisher ◽  
R.A. Rudick ◽  
G. Cutter ◽  
M. Baier ◽  
D. Miller ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Atrophy ◽  
Follow Up Study ◽  
Multiple Sclerosis Patients

Cognitive impairment of Japanese multiple sclerosis patients: Follow-up study using BRB-N assessment tool

2015 ◽  
Vol 359 (1-2) ◽  
pp. 323-327 ◽  
Author(s):  
Fumihito Yoshii ◽  
Shigeharu Takagi ◽  
Eiichiro Nagata ◽  
Yasuhiro Hasegawa ◽  
Naoya Kunika ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Assessment Tool ◽  
Follow Up Study ◽  
Multiple Sclerosis Patients
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