315 The relationship between il-10, il-17, il-23 and vitamin d levels, and disease activity of systemic lupus erythematosus

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the presence of autoantibodies against cell nuclei and immune complexes involving multiple organ systems in the body. The Lupus Foundation estimates about 1.5 million cases of SLE in America and at least 5 million cases of SLE in the world and from year to year, the number of people with lupus also tends to increase. Several laboratory findings are also associated with signs and symptoms of SLE activity including the ratio of neutrophil lymphocytes and vitamin D levels. Method: This study is an observational analytic study using medical record data from central installation patients at H. Adam Malik Hospital in the period December 2019 to March 2021. The sample is calculated using the large proportion estimation formula. Then the distribution test was carried out with the Shapiro Wilk test. Bivariate analysis was carried out to determine the relationship between neutrophil lymphocyte ratio and vitamin D levels with the MEX SLEDAI score using the ANOVA test if the data was normally distributed. Results: 75 subjects participated in the study and there were 12 people (16%) experiencing mild systemic lupus erythematosus, 38 people (51%) moderate degree, and 25 people (33%) severe degree. The neutrophil-lymphocyte ratio was associated with systemic lupus erythematosus disease activity (p=0.001) and vitamin D levels were associated with systemic lupus erythematosus disease activity. Conclusion: Neutrophil-lymphocyte ratio and vitamin D levels are associated with systemic lupus erythematosus disease activity. Keywords: neutrophil lymphocyte ratio, vitamin D levels, systemic lupus erythematosus.

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Vitamin D levels: its relationship to bone mineral density response and disease activity in premenopausal Malaysian systemic lupus erythematosus patients on corticosteroids

International Journal of Rheumatic Diseases ◽

10.1111/j.1756-185x.2011.01653.x ◽

2011 ◽

Vol 15 (1) ◽

pp. 17-24 ◽

Cited By ~ 37

Author(s):

Swan Sim YEAP ◽

Ahmad Zaidi OTHMAN ◽

Amir Azlan ZAIN ◽

Siew Pheng CHAN

Keyword(s):

Bone Mineral Density ◽

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Disease Activity ◽

Bone Mineral ◽

Lupus Erythematosus ◽

Mineral Density ◽

Systemic Lupus ◽

Vitamin D Levels ◽

Density Response

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25-Hydroxy vitamin D levels and its relation to disease activity and cardiovascular risk factors in women with systemic lupus erythematosus

The Egyptian Rheumatologist ◽

10.1016/j.ejr.2011.07.004 ◽

2011 ◽

Vol 33 (4) ◽

pp. 195-201 ◽

Cited By ~ 5

Author(s):

Yasser Ezzat ◽

Safaa Sayed ◽

Wafaa Gaber ◽

Abeer M. Mohey ◽

Tamer Wahid Kassem

Keyword(s):

Risk Factors ◽

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Cardiovascular Risk ◽

Disease Activity ◽

Cardiovascular Risk Factors ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

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Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage

Arthritis Care & Research ◽

10.1002/acr.20186 ◽

2010 ◽

Vol 62 (8) ◽

pp. 1160-1165 ◽

Cited By ~ 86

Author(s):

Guillermo Ruiz-Irastorza ◽

Susana Gordo ◽

Nerea Olivares ◽

Maria-Victoria Egurbide ◽

Ciriaco Aguirre

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Disease Activity ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Vitamin D Levels

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Vitamin D levels in Greek patients with systemic lupus erythematosus

Lupus ◽

10.1177/09612033211066462 ◽

2022 ◽

pp. 096120332110664

Author(s):

Lambros Athanassiou ◽

Ifigenia Kostoglou-Athanassiou ◽

Pavlos Tsakiridis ◽

Eirini Devetzi ◽

Maria Mavroudi ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Disease Activity ◽

Correlation Coefficient ◽

Lupus Erythematosus ◽

Control Group ◽

Systemic Lupus ◽

Vitamin D Levels ◽

Student’S T ◽

Student’S T Test

Objectives Vitamin D deficiency has been observed in autoimmune rheumatic diseases, such as rheumatoid arthritis. The aim was to study vitamin D in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity. Methods In a cohort of 45 patients with SLE, 41 females and 4 males, aged 47.07 ± 2.17 years (mean ± SEM), and range = 21–79 years, 25(OH)D3 levels were determined by electrochemiluminescence. C3 and C4 levels were also analyzed. SLE disease activity was estimated by SLEDAI-2K. Observations were also performed in a control group matched for age and sex. Results In this cohort of SLE patients, 25(OH)D3 levels were 40.36 ± 2.41 nmol/L (mean ± SEM) as opposed to 60.98 ± 4.28 nmol/L in the control group ( p < 0.001, Student’s t test). Vitamin D levels were related to C3 ( p < 0.001, linear regression analysis), correlation coefficient 0.106, r2 = 0.011, and C4 ( p < 0.001); correlation coefficient 0.316 and r2 = 0.100; and inversely related to disease activity ( p < 0.001), correlation coefficient −0.572 and r2 = 0.327. 25(OH)D3 levels were 17.73 ± 1.20 nmol/L and 12.24 ± 0.93 nmol/L, in the groups without and with renal involvement, respectively ( p = 0.001, Student’s t test). Conclusions Vitamin D levels are low in SLE patients and are inversely related to disease activity. Routine screening for vitamin D levels should be performed in SLE patients.

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Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus

Lupus ◽

10.1177/0961203317706557 ◽

2017 ◽

Vol 26 (14) ◽

pp. 1517-1527 ◽

Cited By ~ 8

Author(s):

R Willis ◽

M Smikle ◽

K DeCeulaer ◽

Z Romay-Penabad ◽

E Papalardo ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Disease Activity ◽

Inflammatory Cytokines ◽

Lupus Erythematosus ◽

Cytokine Production ◽

Oxidized Ldl ◽

Systemic Lupus ◽

Vitamin D Levels ◽

Pro Inflammatory Cytokines

Background The abnormal biological activity of cytokines plays an important role in the pathophysiology of both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Several studies have highlighted the association of vitamin D and certain pro-inflammatory cytokines with disease activity in SLE. However, there are limited data on the association of vitamin D and antiphospholipid antibodies (aPL) with various proinflammatory biomarkers in these patients and their relative impact on clinical outcomes. Methods The serum levels of several aPL, 25-hydroxy-vitamin D, pro-inflammatory cytokines including IFNα, IL-1β, IL-6, IL-8, IP10, sCD40L, TNFα and VEGF were measured in 312 SLE patients from the Jamaican ( n = 45) and Hopkins ( n = 267) lupus cohorts using commercial Milliplex and ELISA assays. Oxidized LDL/β2glycoprotein antigenic complexes (oxLβ2Ag) and their associated antibodies were also measured in the Jamaican cohort. Healthy controls for oxidative marker and cytokine testing were used. Results Abnormally low vitamin D levels were present in 61.4% and 73.3% of Hopkins and Jamaican SLE patients, respectively. Median concentrations of IP10, TNFα, sCD40L and VEGF were elevated in both cohorts, oxLβ2Ag and IL-6 were elevated in the Jamaican cohort, and IFNα, IL-1β and IL-8 were the same or lower in both cohorts compared to controls. IP10 and VEGF were independent predictors of disease activity, aPL, IP10 and IL-6 were independent predictors of thrombosis and IL-8, and low vitamin D were independent predictors of pregnancy morbidity despite there being no association of vitamin D with pro-inflammatory cytokines. Conclusions Our results indicate that aPL-mediated pro-inflammatory cytokine production is likely a major mechanism of thrombus development in SLE patients. We provide presumptive evidence of the role IL-8 and hypovitaminosis D play in obstetric pathology in SLE but further studies are required to characterize the subtle complexities of vitamin D’s relationship with cytokine production and disease activity in these patients.

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The Effect of Vitamin D Supplementation on Inflammatory and Hemostatic Markers and Disease Activity in Patients with Systemic Lupus Erythematosus: A Randomized Placebo-controlled Trial

The Journal of Rheumatology ◽

10.3899/jrheum.111594 ◽

2012 ◽

Vol 40 (3) ◽

pp. 265-272 ◽

Cited By ~ 107

Author(s):

ANNA ABOU-RAYA ◽

SUZAN ABOU-RAYA ◽

MADIHAH HELMII

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Disease Activity ◽

Lupus Erythematosus ◽

Serum Levels ◽

Vitamin D Supplementation ◽

Systemic Lupus ◽

Vitamin D Levels ◽

Before And After ◽

Hemostatic Markers

Objective.Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory autoimmune disease. Vitamin D has potent immunomodulatory properties that support its use in the treatment of autoimmune conditions, including SLE. We assessed vitamin D status in patients with SLE and determined alterations in inflammatory and hemostatic markers and disease activity before and after vitamin D supplementation.Methods.Patients with SLE (n = 267) were randomized 2:1 to receive either oral cholecalciferol 2000 IU/day or placebo for 12 months. Outcome measures included assessment of alterations in levels of proinflammatory cytokines and hemostatic markers, and improvement in disease activity before and after 12 months of supplementation. Disease activity was measured by the SLE Disease Activity Index. Vitamin D levels were measured by Liaison immunoassay (normal 30–100 ng/ml). Serum levels between 10 and 30 ng/ml were classified as vitamin D insufficiency and levels < 10 ng/ml as vitamin D deficiency.Results.The mean 25(OH)D level at baseline was 19.8 ng/ml in patients compared to 28.7 ng/ml in controls. The overall prevalence of suboptimal and deficient 25(OH)D serum levels among patients with SLE at baseline was 69% and 39%, respectively. Lower 25(OH)D levels correlated significantly with higher SLE disease activity. At 12 months of therapy, there was a significant improvement in levels of inflammatory and hemostatic markers as well as disease activity in the treatment group compared to the placebo group.Conclusion.Vitamin D supplementation in patients with SLE is recommended because increased vitamin D levels seem to ameliorate inflammatory and hemostatic markers and show a tendency toward subsequent clinical improvement. Clinical Trial Registry NCT01425775.

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