Health-related quality of life after thrombectomy in young-onset versus older stroke patients: a multicenter analysis

BackgroundInformation is lacking on self-reported health-related quality of life (HRQoL) as a complementary outcome measure in addition to the modified Rankin scale (mRS) in young patients with ischemic stroke after endovascular thrombectomy (EVT) compared with older patients.MethodsData on consecutive patients with stroke who underwent thrombectomy (June 2015–2019) from a multicenter prospective registry (German Stroke Registry) were analyzed. HRQoL was measured by the European QoL-5 dimension questionnaire utility index (EQ-5D-I; higher values indicate better HRQoL) 3 months after stroke in patients aged ≤55 and >55 years. Multivariate regression analyses identified predictors of better HRQoL.ResultsOf 4561 included patients, 526 (11.5%) were ≤55 years old. Young-onset patients had a better outcome assessed by mRS (mRS 0–2: 64.3% vs 31.8%, p<0.001) and EQ-5D-I (mean 0.639 vs 0.342, p<0.001). Young survivors after EVT had fewer complaints in the EQ-5D domains mobility (p<0.001), self-care (p<0.001), usual activities (p<0.001) and pain/discomfort (p=0.008), whereas no difference was observed in anxiety/depression (p=0.819). Adjusted regression analysis for 90-day mRS showed no difference in HRQoL between the two subgroups of patients. Lower age, National Institutes of Health Stroke Scale score and pre-stroke mRS, a higher Alberta Stroke Program Early CT Score, concomitant intravenous thrombolysis therapy and successful recanalization were associated with better HRQoL in both patient subgroups.ConclusionsYoung-onset stroke patients have a better HRQoL after EVT than older patients. Their higher HRQoL is mainly explained by less physical disability assessed by mRS. Depressive symptoms should be actively assessed and targeted in rehabilitation therapies of young-onset stroke patients to improve quality of life after stroke.

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Oral health related quality of life and it’s related factors of stroke patients at home in Korea

Archives of Gerontology and Geriatrics ◽

10.1016/j.archger.2015.06.019 ◽

2015 ◽

Vol 61 (3) ◽

pp. 523-528 ◽

Cited By ~ 6

Author(s):

Eun-Jin Jang ◽

Eun-Kyong Kim ◽

Kyeong-Soo Lee ◽

Hee-Kyung Lee ◽

Youn-Hee Choi ◽

...

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Health Related Quality ◽

Stroke Patients ◽

Related Factors ◽

Related Quality ◽

Health Related ◽

At Home

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Clinical phenotype, fibrinogen supplementation and health-related quality of life in patients with afibrinogenemia

Blood ◽

10.1182/blood.2020009472 ◽

2021 ◽

Author(s):

Alessandro Casini ◽

Sylvia von Mackensen ◽

Cristina Santoro ◽

Claudia Djambas Khayat ◽

Meriem Belhani ◽

...

Keyword(s):

Quality Of Life ◽

Family Relationships ◽

Thrombotic Event ◽

Young Patients ◽

Severe Bleeding ◽

Health Related Quality ◽

Cross Sectional ◽

Related Quality ◽

Health Related

Due to its low prevalence, epidemiologic data on afibrinogenemia are limited and none are available on health-related quality of life (HRQoL). We conducted a cross-sectional international study to characterize the clinical features, the fibrinogen supplementation modalities and their impact on HRQoL in patients with afibrinogenemia. A total of 204 patients (119 adults and 85 children) from 25 countries were included. The bleeding phenotype was severe: 68 (33.3%) patients having at least one bleed per month and 48 (23%) a history of cerebral bleeding. About 35% (n=72) of patients were treated with fibrinogen concentrates or cryoprecipitates as prophylaxis, 18.1% (n=37) received more than one injection per week and 16.6% (n=34) were on home treatment. A thrombotic event was reported in venous and/or arterial territories by 37 (18.1%) patients. Thrombosis occurred even in young patients and recurrence was frequent (7.4%). The total HRQoL was lower in children than in adults. Discomfort linked to treatment and limitations to sports and leisure were the main concerns. Women and children were particularly affected in family relationships. In multivariate analyses, younger age, residence in Asia or Africa and a previous thrombotic event were statistically correlated with a worse HRQoL. In conclusion, our study underlines the severe bleeding and thrombotic phenotype and their impact on HRQoL in afibrinogenemia. The optimal strategy for fibrinogen supplementation needs to be determined.

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Health-Related Quality of Life, Functional Decline, and Long-Term Mortality in Older Patients Following Hospitalisation Due to COVID-19

10.21203/rs.3.rs-150067/v1 ◽

2021 ◽

Author(s):

Marte Walle-Hansen ◽

Anette Ranhoff ◽

Marte Mellingsæter ◽

Marte Wang-Hansen ◽

Marius Myrstad

Keyword(s):

Quality Of Life ◽

Older Patients ◽

Functional Decline ◽

Health Related Quality ◽

Negative Change ◽

Related Quality ◽

Health Related

Abstract Background Older people are particularly vulnerable to severe COVID-19. Little is known about long-term consequences of COVID-19 on health-related quality of life and functional status in older people, and the impact of age in this context. We aimed to study age-related change in health-related quality of life (HR-QoL), functional decline and mortality among older patients six months following hospitalisation due to COVID-19. Methods This was a cohort study including patients aged 60 years and older admitted to four general hospitals in South-Eastern Norway due to COVID-19, from March 1 up until July 1, 2020. Patients who were still alive were invited to attend a six-month follow-up. Change in HR-QoL and functional status compared to before the COVID-19 hospitalisation were assessed using the EuroQol 5-dimensional-5 levels questionnaire (EQ 5D-5L). A change in visual analogue scale (VAS) score of 7 or more was considered clinically relevant. Results Out of 216 patients aged 60 years and older that were admitted to hospital due to COVID-19 during the study period, 171 were still alive 180 days after hospital admission, and 106 patients (62%) attended the six-month follow-up. Mean age was 74.3 years, 27 patients (26%) had experienced severe COVID-19. 57 participants (54%) reported a decrease in the EQ5D-5L VAS score after six months, with no significant difference between persons aged 75 years and older compared to younger. 70 participants (66%) reported a negative change in any of the dimensions of the EQ-5D-5L, with impaired ability to perform activities of daily life (35%), reduced mobility (33%) and having more pain or discomfort (33%) being the most commonly reported changes. 46 participants (43%) reported a negative change in cognitive function compared to before the COVID-19 hospitalisation. Six-month mortality was 21%, and increased with increasing age. Conclusions More than half of the patients reported a negative change in HR-QoL six months following hospitalisation due to COVID-19, and one out of three experienced a persistently impaired mobility and ability to carry out activities of daily living. The results suggest awareness of long-term functional decline in older COVID-19 patients.

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Effects of Overactive Bladder Symptoms in Stroke Patients' Health Related Quality of Life and Their Performance Scale

Annals of Rehabilitation Medicine ◽

10.5535/arm.2017.41.6.935 ◽

2017 ◽

Vol 41 (6) ◽

pp. 935 ◽

Cited By ~ 1

Author(s):

Hannah Pyo ◽

Bo Ra Kim ◽

Mina Park ◽

Jeong Hee Hong ◽

Eun Joo Kim

Keyword(s):

Quality Of Life ◽

Overactive Bladder ◽

Health Related Quality ◽

Stroke Patients ◽

Overactive Bladder Symptoms ◽

Related Quality ◽

Health Related ◽

Bladder Symptoms ◽

Performance Scale

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Effects of Chronic Comorbidities on the Health-Related Quality of Life among Older Patients after Falls in Vietnamese Hospitals

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16193623 ◽

2019 ◽

Vol 16 (19) ◽

pp. 3623 ◽

Cited By ~ 8

Author(s):

Hai Minh Vu ◽

Long Hoang Nguyen ◽

Tung Hoang Tran ◽

Kiet Tuan Huy Pham ◽

Hai Thanh Phan ◽

...

Keyword(s):

Quality Of Life ◽

Older Patients ◽

Health Related Quality ◽

Tobit Regression ◽

Cross Sectional ◽

Fall Injuries ◽

Spine Diseases ◽

Related Quality ◽

Health Related

Although comorbidities are prevalent in older people experiencing falls, there is a lack of studies examining their influence on health-related quality of life (HRQOL) in this population. This study examines the prevalence of comorbidities and associations between comorbidities and HRQOL in older patients after falls in Vietnamese hospitals. A cross-sectional design was employed among 405 older patients admitted to seven hospitals due to fall injuries in Thai Binh province, Vietnam. The EuroQol-5 Dimensions-5 Levels (EQ-5D-5L) was used to measure HRQOL. Socio-demographic characteristics were collected using a structured questionnaire, while comorbidities and other clinical characteristics were examined by physicians and extracted from medical records. Multivariate Tobit regression was used to determine the associations between comorbidities and HRQOL. Among 405 patients, 75.6% had comorbidities, of which hypertension and osteoarthritis were the most common. Lumbar spine/cervical spine diseases (Coefficient (Coef.) = −0.10; 95%CI = −0.18; 0.03) and stroke (Coef. = −0.36; 95%CI = −0.61; −0.10) were found to be associated with a significantly decreased EQ-5D index. Participants with three comorbidities had EQ-5D indexes 0.20 points lower (Coef. = −0.20; 95%CI = −0.31; −0.09) in comparison with those without comorbidities. This study underlined a significantly high proportion of comorbidities in older patients hospitalized due to fall injuries in Vietnam. In addition, the existence of comorbidities was associated with deteriorating HRQOL. Frequent monitoring and screening comorbidities are critical to determining which individuals are most in need of HRQOL enhancement.

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A Study On Health-Related Quality of Life Among The Stroke Patients In A Tertiary Care Hospital, Mangalore

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1708766 ◽

2018 ◽

Vol 08 (04) ◽

pp. 007-010

Author(s):

G Shiny Chrism Queen Nesan ◽

Rashmi Kundapur

Keyword(s):

Quality Of Life ◽

Care Hospital ◽

Physical Domain ◽

Health Related Quality ◽

Stroke Patients ◽

Poor General Health ◽

Related Quality ◽

Health Related ◽

The Impact

Abstract Introduction : Stroke is a leading cause of death and acquired human disability in India. One dimension that is rarely measured, is health-related quality of life (HRQOL) which aims to assess the impact of disease from the perspective of the patient. Objectives : To study the health-related quality of life among stroke patients within 3 months of stroke. Materials & Methods : A hospital based study conducted on 20 stroke patients from the registry. The patients with fresh stroke attack and those who were attending the follow up within the first 3 months of the attack were enrolled in the study. Basic demographic data and the data of stroke outcomes were taken. HRQOL was evaluated using the Indian version of the Medical Outcomes Study 36 item Short-Form Health Survey (SF-36). Frequency and percentages were calculated. Results: It was seen that majority (55%) of patients expressed a fair physical domain post stroke. About 40% were of opinion that their physical domain was poor and the rest said that it was good (5%). Assessing the psychological domain, majority of the patients said it was poor. Of the 20 patients, 15 (75%) of them were scaled to have poor social domain and the rest (25%) said it was fair. About half (50%) of the patients showed that they had poor environmental domain. About 15% of them said that it was good. Majority (60%) of the patients had poor general health status.

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A Comparison of the Long-term Health Related Quality of Life and Handicap of Stroke Patients in Mainland China and Hong Kong

Health Services Insights ◽

10.1177/117863291000300001 ◽

2010 ◽

Vol 3 ◽

pp. 117863291000300

Author(s):

T Kwok ◽

X Jin ◽

F Yeung ◽

J Cheng ◽

RSK Lo ◽

...

Keyword(s):

Quality Of Life ◽

Hong Kong ◽

Mainland China ◽

Stroke Survivors ◽

Health Related Quality ◽

Stroke Patients ◽

Related Factors ◽

Related Quality ◽

Health Related

Purpose To compare health related quality of life (HRQOL) and handicap of stroke survivors in Hong Kong (HK) and Chengdu (CD) in Mainland China. Method Fifty-four pairs of first ever stroke patients in CD and in HK matched by age, sex and Modified Barthel Index (MBI) were interviewed using a structured questionnaire at 16–36 months after stroke. HRQOL and handicap outcomes were evaluated by the Chinese version of the Short-Form Health Survey (SF-36) and London Handicap Scale (LHS) respectively. Results Compared to stroke patients in CD, HK subjects reported significantly greater handicap, especially in the occupation domain. HK subjects also had significantly lower HRQOL Z scores in domains of role limitations due to emotional or physical problems, and bodily pain. CD subjects had more social support, but had more difficulties in meeting medical costs, and were less likely to have regular medical follow-up and dysphagia symptom. After adjusting for social and health related factors, the site differences in handicap and the role limitation (physical) domain of SF36 became insignificant. Conclusions CD stroke survivors had better scores in HRQOL and fewer handicaps than their counterparts in HK, because of social and health related factors.

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A prognostic model predicted deterioration in health-related quality of life in older patients with multimorbidity and polypharmacy

Journal of Clinical Epidemiology ◽

10.1016/j.jclinepi.2020.10.006 ◽

2021 ◽

Vol 130 ◽

pp. 1-12

Author(s):

Ana I. González-González ◽

Andreas D. Meid ◽

Truc S. Dinh ◽

Jeanet W. Blom ◽

Marjan van den Akker ◽

...

Keyword(s):

Quality Of Life ◽

Older Patients ◽

Prognostic Model ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Fear of Falling among Older Patients Admitted to Hospital after Falls in Vietnam: Prevalence, Associated Factors and Correlation with Impaired Health-Related Quality of Life

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17072493 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2493 ◽

Cited By ~ 2

Author(s):

Long Hoang Nguyen ◽

Giang Thu Vu ◽

Giang Hai Ha ◽

Cuong Tat Nguyen ◽

Hai Minh Vu ◽

...

Keyword(s):

Quality Of Life ◽

Older Patients ◽

Associated Factors ◽

Fear Of Falling ◽

Negative Relationship ◽

Health Related Quality ◽

Fall Injuries ◽

Related Quality ◽

Health Related

Fear of falling (FOF) diminishes older people’s independence in daily activities, as well as causes serious health and economic consequences. This study examined the prevalence of FOF in older patients hospitalized due to fall-injuries, its effect on health-related quality of life (HRQOL), and its associated factors. We conducted a cross-sectional study in seven hospitals in Thai Binh, Vietnam. FOF was assessed using a single close-ended question. HRQOL was evaluated by the EQ-5D-5L instrument. Multilevel logistic regression and Tobit regression models were utilized. The prevalence of FOF in 405 older patients admitted to hospitals after fall injuries was 88.2%, with a mean EQ-5D index and EQ-VAS of 0.34 (SD = 0.38) and 61.6 (SD = 15.2), respectively. Factors associated with FOF included living alone (OR = 0.13, 95%CI = 0.04; 0.50.,), history of eye diseases (OR = 4.12; 95%CI = 1.91; 8.89), and experiencing psychological distress (OR= 3.56, 95% CI = 1.05; 12.00). After adjusting for confounders, the EQ-5D index in the FOF group reduced by 0.15 points (Coef. = −0.15; 95%CI= −0.24; −0.05) compared to that of non-FOF group. Our study shows that FOF had an independent negative relationship with HRQOL of patients. Improving knowledge about fall prevention in patients and caregivers could reduce the burden of falls in older people.

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