Guess Who: dopamine agonist and creativity?

2021 ◽  
pp. practneurol-2021-003104
Author(s):  
Paula Pérez-Torre
Keyword(s):  
Author(s):  
I.C. Murray

In women, hyperprolactinemia is often due to a prolactin (PRL)-secreting adenoma or PRL cell hyperplasia. RRL excess stimulates the mammary glands and causes proliferation of the alveolar epithelium. Bromocriptine, a dopamine agonist, inhibits PRL secretion and is given to women to treat nonpuerperal galactorrhea. Old female rats have been reported to have PRL cell hyperplasia or adenoma leading to PRL hypersecretion and breast stimulation. Herein, we describe the effect of bromocriptine and consequently the reduction in serum PRL levels on the ultrastructure of rat mammary glands.Female Long-Evans rats, 23 months of age, were divided into control and bromocriptine-treated groups. The control animals were injected subcutaneously once daily with a 10% ethanol vehicle and were later divided into a normoprolactinemic control group with serum PRL levels under 30 ng/ml and a hyperprolactinemic control group with serum PRL levels above 30 ng/ml.


2012 ◽  
Author(s):  
A. Y. Egorov ◽  
E. O. Kutcher ◽  
N. A. Chernikova ◽  
E. V. Filatova

2005 ◽  
Vol 32 (06) ◽  
Author(s):  
P Odin ◽  
C Oehlwein ◽  
A Storch ◽  
U Polzer ◽  
G Werner ◽  
...  

2017 ◽  
Author(s):  
Shang Shaho ◽  
William Martin Drake
Keyword(s):  

Author(s):  
Chávez Hernández María Margarita ◽  
Jiménez Báez María Valeria ◽  
Armijo Medina María Fernanda ◽  
Domínguez Leyva Jorge Miguel ◽  
Góngora Valencia Karen Alejandra ◽  
...  

Prolactinomas are the most common type of functional pituitary tumor. The present manuscript is an update on the treatment modalities for prolactinomas. Effective hyperprolactinemia treatment is of great importance, due to its potential deleterious effects including infertility, gonadal dysfunction and osteoporosis. Dopamine agonist therapy is the first line of treatment for prolactinomas; recurrence of disease after cessation of the drug may occur in patients. Its safety profile remains high, allowing its use during pregnancy.


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