scholarly journals Intrabullous blood injection for lung volume reduction

Thorax ◽  
2008 ◽  
Vol 63 (6) ◽  
pp. 564-565 ◽  
Author(s):  
S Kanoh ◽  
H Kobayashi ◽  
K Motoyoshi
Keyword(s):  
Lung Volume ◽  
Lung Diseases ◽  
Autologous Blood ◽  
Volume Reduction ◽  
Body Plethysmography ◽  
Lung Volume Reduction ◽  
Emphysematous Lung ◽  
Autologous Blood Injection ◽  
Blood Injection ◽  
The Right

Bronchoscopic treatment for emphysematous lung diseases has attracted clinical attention, and several different approaches are being investigated. We present a case of emphysematous bullae that was effectively treated with a newly developed bronchoscopic intervention, autologous blood injection. A 59-year-old man was referred to our institution with exertional dyspnoea. Chest CT showed emphysema and bullae with a diameter of 12 cm in the right upper lobe. Bronchoscopic treatment was introduced as an alternative to surgery. Autologous blood and fibrinogen solution were infused into bullae via the transbronchial catheter, under fluoroscopic guidance. Post-treatment CT showed marked contraction of bullae to a diameter of 3 cm, corresponding to a volume reduction of 800 ml on body plethysmography. A significant reduction in dyspnoea was also noted. This therapeutic approach is less invasive and may represent a good option for reducing lung volume.

Significant Differences in Body Plethysmography Measurements Between Hospitals in Patients Referred for Bronchoscopic Lung Volume Reduction

Lung ◽  
2019 ◽  
Vol 197 (5) ◽  
pp. 573-576
Author(s):  
Jorrit B. A. Welling ◽  
Jorine E. Hartman ◽  
Nick H. T. Ten Hacken ◽  
Sonja W. S. Augustijn ◽  
Huib A. M. Kerstjens ◽  
...  
Keyword(s):  
Lung Volume ◽  
Volume Reduction ◽  
Body Plethysmography ◽  
Lung Volume Reduction

scholarly journals A Patient with GOLD Stage 3 COPD « cured » by One-Way Endobronchial Valves

Medicina ◽  
2019 ◽  
Vol 55 (3) ◽  
pp. 65
Author(s):  
Eric Marchand ◽  
Jean-Paul d’Odemont ◽  
Michael V Dupont
Keyword(s):  
Lung Volume ◽  
Lower Lobe ◽  
Volume Reduction ◽  
Chronic Obstructive ◽  
Therapeutic Approaches ◽  
Lung Volume Reduction ◽  
Obstructive Pulmonary Disease ◽  
Gold Stage ◽  
Appropriate Therapy ◽  
The Right

Lung hyperinflation is a main determinant of dyspnoea in patients with chronic obstructive pulmonary disease (COPD). Surgical or bronchoscopic lung volume reduction are the most efficient therapeutic approaches for reducing hyperinflation in selected patients with emphysema. We here report the case of a 69-year old woman with COPD (GOLD stage 3-D) referred for lung volume reduction. She complained of persistent disabling dyspnoea despite appropriate therapy. Chest imaging showed marked emphysema heterogeneity as well as severe hyperinflation of the right lower lobe. She was deemed to be a good candidate for bronchoscopic treatment with one-way endobronchial valves. In the absence of interlobar collateral ventilation, 2 endobronchial valves were placed in the right lower lobe under general anaesthesia. The improvement observed 1 and 3 months after the procedure was such that the patient no longer met the pulmonary function criteria for COPD. The benefit persisted after 3 years.

Spontaneous rupture of the right hemidiaphragm after video-assisted lung volume reduction operation

2002 ◽  
Vol 74 (3) ◽  
pp. 929-931 ◽  
Author(s):  
Serban C Stoica ◽  
Stewart R Craig ◽  
Sing Yang Soon ◽  
William S Walker
Keyword(s):  
Lung Volume ◽  
Spontaneous Rupture ◽  
Volume Reduction ◽  
Lung Volume Reduction ◽  
Reduction Operation ◽  
Video Assisted ◽  
The Right

scholarly journals Crosslink bio-adhesives for bronchoscopic lung volume reduction: current status and future direction

2021 ◽  
Vol 30 (162) ◽  
pp. 210142
Author(s):  
Mugdha M. Joglekar ◽  
Dirk-Jan Slebos ◽  
Jeroen Leijten ◽  
Janette K. Burgess ◽  
Simon D. Pouwels
Keyword(s):  
Lung Volume ◽  
Inflammatory Responses ◽  
Autologous Blood ◽  
Treatment Options ◽  
Therapeutic Benefit ◽  
Volume Reduction ◽  
Current Status ◽  
Self Healing ◽  
Lung Volume Reduction ◽  
Major Drawback

Several bronchoscopic lung volume reduction (BLVR) treatments have been developed to reduce hyperinflation in emphysema patients. Lung bio-adhesives are among the most promising new BLVR treatment options, as they potentially provide a permanent solution for emphysematous patients after only a single application. To date, bio-adhesives have mainly been used as haemostats and tissue sealants, while their application in permanently contracting and sealing hyperinflated lung tissue has recently been identified as a novel and enticing opportunity. However, a major drawback of the current adhesive technology is the induction of severe inflammatory responses and adverse events upon administration. In our review, we distinguish between and discuss various natural, semi-synthetic and synthetic tissue haemostats and sealants that have been used for pulmonary applications such as sealing air/fluid leaks. Furthermore, we present an overview of the different materials including AeriSeal and autologous blood that have been used to achieve lung volume reduction and discuss their respective advantages and drawbacks. In conclusion, we describe the key biological (therapeutic benefit and biocompatibility) and biomechanical (degradability, adhesive strength, stiffness, viscoelasticity, tunability and self-healing capacity) characteristics that are essential for an ideal lung bio-adhesive material with the potential to overcome the concerns related to current adhesives.

Morphologic Grading of the Emphysematous Lung and Its Relation to Improvement After Lung Volume Reduction Surgery

1998 ◽  
Vol 65 (3) ◽  
pp. 793-799 ◽  
Author(s):  
Wilfried Wisser ◽  
Walter Klepetko ◽  
Manfred Kontrus ◽  
Alex Bankier ◽  
Ömer Senbaklavaci ◽  
...  
Keyword(s):  
Lung Volume ◽  
Volume Reduction ◽  
Lung Volume Reduction Surgery ◽  
Lung Volume Reduction ◽  
Emphysematous Lung

scholarly journals Clinical vignette of bronchoscopic thermal vapour ablation: Malaysians’ first experience

2020 ◽  
pp. 201010582095703
Author(s):  
Nurashikin Mohammad ◽  
Mona Zaria Nasaruddin ◽  
Rosmadi Ismail ◽  
Jamalul Azizi Bin Abdul Rahaman
Keyword(s):  
Lung Volume ◽  
Forced Expiratory Volume ◽  
Volume Reduction ◽  
Final Decision ◽  
Lung Volume Reduction ◽  
Multidisciplinary Meeting ◽  
First Case ◽  
Centre Of Excellence ◽  
The Right ◽  
Multiple Experts

We report a case of severe emphysema with bullae in a patient who underwent the new technique of bronchoscopic lung volume reduction to the right upper lobe. He was symptomatic with breathlessness and frequent exacerbations. He was not deemed suitable for a surgical lung volume reduction or bullectomy due to a very low forced expiratory volume in one second (FEV1). Endobronchial valves were not considered due to the incomplete fissures. The case was carefully screened, and was discussed in a multidisciplinary meeting prior to the final decision. This was the first case in Malaysia of bronchoscopic thermal vapour ablation (BTVA) for severe advanced emphysema. Multiple experts were involved prior, during and after the procedure. Despite having a poor lung reserve, he came through the procedure successfully with no immediate complications. His serial spirometry showed a 50% improvement at six months compared to baseline. This case highlights the important role of a multidisciplinary meeting, expert opinion and the careful selection of which patients should undergo BTVA. The procedure should be carried out at a centre of excellence in order to achieve a successful procedure.

scholarly journals Use of 3-D navigation to target the site of autologous blood installation for lung volume reduction in bullous emphysema

2020 ◽  
Vol 17 ◽  
pp. 147997312090355
Author(s):  
Juergen Hetzel ◽  
Michael Boeckeler ◽  
Richard A Lewis ◽  
Marius Horger ◽  
Maik Haentschel
Keyword(s):  
Lung Volume ◽  
Marked Improvement ◽  
Autologous Blood ◽  
Three Dimensional ◽  
Volume Reduction ◽  
Lung Volume Reduction ◽  
Electromagnetic Navigation ◽  
Giant Bulla ◽  
Electromagnetic Navigation System ◽  
Giant Bullae

Bronchoscopic lung volume reduction (BLVR) using intrabullous autologous blood instillation has been reported in single cases where other techniques are not possible. We present the use of three-dimensional navigation to instill autologous blood into emphysematous bullae for BLVR. A 62-year-old man presented with increasing dyspnea, due to emphysema with a conglomerate of giant bullae with two particularly large bullae. Surgical treatment was refused, so bronchoscopic autologous blood instillation into the bronchial segment leading to the large bullae was attempted, but was unsuccessful; blood failed to penetrate into the bullous cavity. Dyspnea worsened over the following year. We therefore performed another bronchoscopy and punctured a large bulla with a needle and created a tunnel from the central airways. Puncture position and direction were determined using a prototype of an electromagnetic navigation system. Under fluoroscopic guidance, a catheter was placed via the tunnel into the bulla and blood was instilled. This resulted in an almost complete shrinkage of the bullae, reduction of residual volume, and marked improvement in dyspnea within 4 months. To our knowledge, this is the first reported case of successful BLVR by navigated bronchoscopy with transbronchial puncture, dilatation, and autologous blood instillation into a giant bulla.

Effects of endoscopic lung volume reduction on right ventricular myocardial function in patients with advanced emphysema

Pneumologie ◽  
2014 ◽  
Vol 68 (S 01) ◽  
Author(s):  
C Pizarro ◽  
R Schueler ◽  
C Hammerstingl ◽  
J Kreuz ◽  
U Juergens ◽  
...  
Keyword(s):  
Right Ventricular ◽  
Lung Volume ◽  
Myocardial Function ◽  
Volume Reduction ◽  
Lung Volume Reduction
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