Adverse Drug Reaction Monitoring of Antidepressant Drugs in a Mental Health Institute in Odisha

Introduction: Antidepressants are used primarily in the management of depressive and anxiety disorders. The occurrence of adverse drug reactions (ADRs) to antidepressants is a major challenge as it influences patient compliance. Aim: The aim of this study was to find out the ADR profile of antidepressant drugs in a mental health institute in Odisha. Materials and Methods: This is a cross sectional observational study conducted in Department of Pharmacology in collaboration with Mental Health Institute (Centre of Excellence) S.C.B Medical College and Hospital, Cuttack from September 2017 to September 2019. Patients who received at least one antidepressant drug were included in the study irrespective of age and sex. Data were collected by interviewing the patients or attendants and on detection of ADR, it was recorded on suspected ADR reporting form designed by PvPI. Causality, severity and preventability of ADRs were assessed by, WHO-UMC causality assessment, modified Hartwig-Siegel Scale and modified Schumock-Thornton criteria respectively. Results: Out of 180 patients taking antidepressants, ADRs were reported in 24% of patients, with either possible or probable causality. None were labelled as certain. ADRs were observed in 50% of patients who received TCAs and among 34.5% who received polytherapy. Insomnia (27%), fatigue (17%) and agitation (13%) were most common ADRs. Most of the ADRs were of mild severity (91%) and not preventable (84%). Conclusion: Insomnia, fatigue and agitation were among most common ADRs. There was increased chance of ADRs with polytherapy and use of TCAs. Most ADRs were mild and not preventable.

Data dissemination by Uganda Bureau of Statistics

Data plays a big role in educating the population on various issues that contribute to development. One of the major activities conducted after data collection is, dissemination of the data to different stakeholders. Uganda Bureau of Statistics disseminates data to its users through a number of channels. This paper discusses each method in detail and how it's used during this process. The major channel of sharing data with users is through dissemination workshops and the website. Other channels used for dissemination include the library and resource centre, social media and physical delivery to stakeholders in district public libraries. Having the above-mentioned channels of data dissemination in place, has helped UBOS remain the centre of excellence in dissemination of data to users, countrywide and in Africa.

History of Emotions: Where Are We?

As we celebrate the tenth anniversary of the establishment of the CHE, the Australian Research Council Centre of Excellence for the History of Emotion (initially focusing on Europe 1100–1800 and with the late Professor Philippa Maddern as its founding Director) and the fifth anniversary of the launch of the journal Emotions: History, Culture, Society (founding Editors: Katie Barclay, Andrew Lynch, Giovanni Tarantino), it is only pertinent that we look back and assess our efforts by hearing from some prominent emotions scholars who contributed in different ways and capacities to this pathbreaking intellectual journey.

Measuring the ICT Sector in the Digital Economy

The article addresses the problem of measuring the Information and Communication Technology (ICT) sector and its relationship to the digital economy as defined in the OECD «Guidelines for Supply-Use Tables for the Digital Economy». Analysis of various concepts of the digital economy shows that the ICT sector is its key element. It is stressed that, in line with the OECD recommendations, the measurement of the digital economy should be based on the SNA satellite account, the core element of which are the Digital Supply-Use Tables (Digital SUTs). This approach enables to reflect most fully within a single statistical model integration of all phases of digital products (goods and services) circulation in the national economy.It is noted that the construction of ICT Supply-Use Tables (SUTs) is a critical self-contained task, as it provides a measurement framework for both digital (regardless of the model to be adopted) and (more broadly) information economy.It is stressed that the ability to capture the use of ICT products as well as the cost of their production depends significantly on the identification and valuation of digital products and industries in the Digital SUTs. The identification of such industries is now a major challenge because of the lack of separate activities in the existing industrial classifications that are characteristic for their constituent units.The article concludes with a presentation of the pilot estimates of ICT Sector SUTs core indicators obtained by the authors at the Economic Statistics Centre of Excellence, HSE University. The contribution of the sector to the GDP of the Russian Federation is analysed and its inter-sectoral linkages, both on the demand and supply side, are assessed. It is concluded that the full implementation of the Digital SUTs depends on the inclusion in the new International Standard Industrial Classification (ISIC) the additions necessary to identify and evaluate digital products and industries.

Accounting for Complexity and Context in Implementation through Coaching, Convening, and Co-Design: A New Intermediary’s Approach

The Centre of Excellence on PTSD (the Centre) is a new Canadian intermediary established in part to support the uptake of evidence-based practices among service providers treating veterans. Given the unique and complex landscape for veteran mental health service delivery, the Centre is developing networks and prioritizing co-design to address anticipated implementation challenges.

Measurement of C1-Inhibitor function alone is sufficient for diagnosis of hereditary angioedema

The World Allergy Organisiation/European Academy of Allergy and Clinical Immunology (WAO/EAACI) 2017/2018 guidelines recommend measuring complement4 levels, followed by C1-inhibitor level and function for diagnosis of hereditary angioedema (HAE). We analysed 6 months’ worth of data generated in our laboratory which is a specialist regional immunology service and also provides laboratory service for the Barts Health immunology department, which is a GA2LEN/HAEi-Angioedema Centre of Excellence and Reference (ACARE) and hence, investigates a large number of patients for HAE. We found that an efficient and sensitive approach for laboratory diagnosis of HAE is to only test the C1-inhibitor function. This approach had a sensitivity of 100% and reduced the cost of laboratory investigations for HAE diagnosis by 45%.

Stuart Cunningham: From creative industries to creative economies, and beyond

This paper explores Stuart Cunningham’s thought leadership in ‘creative’ spaces since the turn of the millennium. It presents the author's personal glimpses of Cunningham's contributions to scholarship and advocacy, ranging from Cunningham and Hartley's exposé on the recently-titled creative industries at the National Humanities and Social Sciences Summit (Canberra, 2001), through the establishment of QUT's Centre of Excellence (Brisbane, 2005) and its European node (London, 2008), to Cunningham's more recent work with creative economies and their opportunities, including his influence upon Australia's Cultural and Creative Economy: A 21st-Century Guide (Canberra, 2020). The paper concludes with some comments about continuing resistance to substantial investment in Australia's creative industries, and Cunningham's call for a more united voice in their advocacy.