THE BINDING OF ETHACRYNIC ACID TO BOVINE SERUM ALBUMIN
1967 ◽
Vol 45
(9)
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pp. 1433-1443
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Keyword(s):
Studies with 14C-labelled ethacrynic acid indicated that this potent diuretic binds to the albumin fraction of plasma protein. An investigation of the variation of molar binding as a function of the molar concentration ratio revealed that a mole of bovine serum albumin can bind 4 moles of ethacrynic acid strongly (probably irreversibly) and approximately 12 moles reversibly at pH 7.4. Further, it appears that the protein could accommodate a maximum of approximately 16 reversibly bound moles of ethacrynic acid at this pH. Efforts to determine the chemical identity of specific binding sites did not allow positive assignments.
2000 ◽
Vol 04
(02)
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pp. 147-157
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Keyword(s):
1975 ◽
Vol 250
(7)
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pp. 2487-2494
Keyword(s):
1986 ◽
Vol 261
(33)
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pp. 15619-15624
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Keyword(s):
Keyword(s):
Keyword(s):
1995 ◽
Vol 269
(5)
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pp. H1514-H1521
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1991 ◽
Vol 181
(2)
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pp. 787-796
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Keyword(s):
Keyword(s):
2007 ◽
Vol 1774
(11)
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pp. 1359-1369
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Keyword(s):
2012 ◽
Vol 2012
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pp. 1-9
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