Fructose-induced adenine nucleotide catabolism in isolated rat hepatocytes
1977 ◽
Vol 55
(12)
◽
pp. 1237-1240
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Keyword(s):
The mechanism of fructose-induced nucleotide catabolism was studied using isolated rat hepatocytes in which the adenine nucleotide pool was prelabelled with [14C]adenine. Incubation of these cells with fructose caused a rapid depletion of the adenine nucleotides and a corresponding increase in allantoin. There was no accumulation of radioactivity in adenosine in the presence or absence of the adenosine deaminase inhibitor 9-erythro-(2-hydroxy-3-nonyl)adenine. This confirms the previous hypothesis that fructose-induced adenine nucleotide catabolism occurs by way of AMP deaminase (AMP amino-hydrolase, EC 3.5.4.6).
1977 ◽
Vol 55
(11)
◽
pp. 1134-1139
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1997 ◽
Vol 240
(3)
◽
pp. 697-700
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Keyword(s):