Intramolecular amidation — An efficient synthesis of 3-aryl-2-quinolinones

2006 ◽  
Vol 84 (12) ◽  
pp. 1620-1625 ◽  
Author(s):  
Yinggang Luo ◽  
Feiyan Tao ◽  
Yan Liu ◽  
Bogang Li ◽  
Guolin Zhang
Keyword(s):  
Key Words ◽  
Functional Groups ◽  
Organic Solvents ◽  
Reaction Temperature ◽  
Efficient Synthesis ◽  
Efficient Procedure ◽  
Condensation Products ◽  
Phenyl Rings ◽  
Key Words 3 ◽  
Intramolecular Amidation

To reveal the scope of the syntheses of 3-aryl-2-quinolinones from 2-nitro-α-phenylcinnamic acids, the isomerization of (E)-2-amino-α-phenylcinnamic acids was studied. The results showed that (E)-2-amino-α-phenylcinnamic acids were isomerized to its (Z)-forms under sunlight in organic solvents. The reaction temperature and the functional groups at both phenyl rings have no effect on the isomerization of (E)-2-amino-α-phenylcinnamic acids and the following intramolecular spontaneous amidation of (Z)-2-amino-α-phenylcinnamic acids. Various 3-aryl-2-quinolinones prepared in high total yields indicated that the syntheses of 3-aryl-2-quinolinones from Perkin condensation products 2-nitro-α-phenylcinnamic acids via reduction, sunlight-induced isomerization of (E)-2-amino-α-phenylcinnamic acids, and the following intramolecular amidation is an efficient procedure. Key words: 3-aryl-2-quinolinones, isomerization, amidation.

scholarly journals Rapid and Efficient Synthesis ofω-Alkylenediphosphoric Acids from Phosphorus Oxychloride

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Dalila Meziane ◽  
Abdelhamid Elias ◽  
Erwann Guénin
Keyword(s):  
Microwave Irradiation ◽  
Reaction Temperature ◽  
Phosphorus Oxychloride ◽  
Molar Ratio ◽  
Efficient Synthesis ◽  
Selective Method

The aim of this investigation was to develop an efficient, rapid, and selective method for the synthesis ofω-alkylenediphosphoric acids (HO)2(O)P-O-CH2n-O-P(O)(OH)2from reaction of several diols with phosphorus oxychloride. The reaction was investigated using three methodologies: (i) presence of a base, (ii) classical heating, and (iii) use of microwave irradiation. Influence of reaction temperature and molar ratio of reagents, as well as the nature of the solvent, was studied using these three different methods.

scholarly journals Toxicity of Thevetia peruviana (Pers) Schum. Extract to Adults of Callosobruchus maculatus F. (Coleoptera: Bruchidae)

1970 ◽  
pp. 105-109 ◽  
Author(s):  
JU Mollah ◽  
W Islam
Keyword(s):  
Ethyl Acetate ◽  
Key Words ◽  
Organic Solvents ◽  
Callosobruchus Maculatus ◽  
Root Extract ◽  
Thevetia Peruviana

Leaf, stem and roots of Thevetia peruviana (Pers) Schum. were extracted in four organic solvents; petroleum spirit, ethyl acetate, acetone and methanol and tested against the adults of Callosobruchus maculatus F. All the tested extracts effectively produced mortality of C. maculatus and their toxicity was in order of solvents: petroleum spirit>ethyl acetate>acetone>methanol. Root extract was the most toxic to C. maculatus. Females were more tolerant than males. Key words: Extract, mortality, solvent, Thevetia peruviana, Callosobruchus maculatus. DOI = 10.3329/jard.v5i1.1466 J Agric Rural Dev 5(1&2), 105-109, June 2007

scholarly journals RESEARCH OF INFLUENCE OF CROSS-LINKING AGENTS ON CHARACTERISTICS OF SPATIAL GRID AND PROPERTIES OF URETHANE POLYMER

2018 ◽  
Vol 59 (7) ◽  
pp. 86
Author(s):  
Inna Slepchuk ◽  
Olga Ya. Semeshko ◽  
Yuliya G. Saribekova ◽  
Irina N. Kulish ◽  
Igor V. Gorokhov
Keyword(s):  
Mechanical Properties ◽  
Functional Groups ◽  
Organic Solvents ◽  
Three Dimensional ◽  
Physical And Mechanical Properties ◽  
Polymeric Films ◽  
Cross Linking ◽  
Glycidyl Ethers ◽  
Equilibrium Swelling ◽  
Spatial Grid

Results of study of influence of amount of functional groups of glycidyl ethers on characteristics of the spatial grid of crosslinked polyurethane polymer are presented. Parameters of a three-dimensional spatial grid of investigated samples of polymeric films and their physical and mechanical properties were determined by a method of equilibrium swelling in organic solvents.

scholarly journals Facile Deoxygenation of Hydroxylated Flavonoids by Palladium-Catalysed Reduction of its Triflate Derivatives

2005 ◽  
Vol 60 (7) ◽  
pp. 792-796 ◽  
Author(s):  
József Kövér ◽  
Sándor Antus
Keyword(s):  
Formic Acid ◽  
Functional Groups ◽  
Catalytic Amount ◽  
Palladium Acetate ◽  
Efficient Procedure ◽  
Related Compounds

An efficient procedure to deoxygenate hydroxy substituted flavonoids, isoflavonoids and related compounds via their trifluoromethanesulfonates is presented. Their reduction with formic acid in the presence of a catalytic amount of palladium acetate, triethylamine and 1,3-bis(diphenylphosphanyl) propane (dppp) in DMF results in their des-hydroxy derivatives without affecting other functional groups.

Efficient Synthesis of 3,4-Disubstituted 7-Azaindoles Employing SEM as a Dual Protecting–Activating Group

Synlett ◽  
2019 ◽  
Vol 30 (20) ◽  
pp. 2273-2278 ◽  
Author(s):  
Piroska Gyárfás ◽  
János Gerencsér ◽  
Warren S. Wade ◽  
László Ürögdi ◽  
Zoltán Novák ◽  
...  
Keyword(s):  
Functional Groups ◽  
Efficient Method ◽  
Reaction Times ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Efficient Synthesis ◽  
Mild Conditions

An efficient method for nucleophilic aromatic substitution on 7-azaindoles has been developed. The reaction is facilitated by the unique dual influence of SEM as both protecting and activating group, permitting mild conditions and short reaction times that are compatible with sensitive functional groups. The method is suitable for the synthesis of a broad range of products, most notably ethers.

Bis-ammonium immobilized polystyrenes with co-catalyzing functional end groups as efficient and reusable heterogeneous catalysts for synthesis of cyclic carbonate from CO2 and epoxides

RSC Advances ◽  
2016 ◽  
Vol 6 (3) ◽  
pp. 2217-2224 ◽  
Author(s):  
Qingyuan Deng ◽  
Gaohong He ◽  
Yu Pan ◽  
Xuehua Ruan ◽  
Wenji Zheng ◽  
...  
Keyword(s):  
Functional Groups ◽  
Heterogeneous Catalysts ◽  
Cyclic Carbonate ◽  
Efficient Synthesis ◽  
End Groups

Novel bis-ammonium immobilized polystyrenes with co-catalyzing functional groups were prepared for efficient synthesis of cyclic carbonate from CO2 and epoxides.

Noncovalent Macromolecular Architectures of Oligo(p-phenylenevinylene)s (OPVs): Role of End Functional Groups on the Gelation of Organic Solvents

2008 ◽  
Vol 273 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Sukumaran S. Babu ◽  
Vakayil K. Praveen ◽  
Ayyappanpillai Ajayaghosh
Keyword(s):  
Functional Groups ◽  
Organic Solvents

A short synthesis of both enantiomers of enterolactone

2000 ◽  
Vol 78 (1) ◽  
pp. 133-138 ◽  
Author(s):  
Mukund P Sibi ◽  
Pingrong Liu ◽  
Michael D Johnson
Keyword(s):  
Key Words ◽  
Enantioselective Synthesis ◽  
Efficient Synthesis ◽  
Short Synthesis

A short and efficient synthesis of both enantiomers of enterolactone, a mammalian lignan, is described. The overall yield for the natural enterolactone, over seven steps, was 19% and for its enantiomer 27%. Key words: enterolactone, 4-diphenylmethyl-2-oxazolidinone, succinate, enantioselective synthesis.

Copper/B2pin2-catalyzed C–H difluoroacetylation–cycloamidation of anilines leading to the formation of 3,3-difluoro-2-oxindoles

2017 ◽  
Vol 53 (14) ◽  
pp. 2222-2225 ◽  
Author(s):  
Miaolin Ke ◽  
Qiuling Song
Keyword(s):  
Efficient Synthesis ◽  
Intramolecular Amidation

An original and efficient synthesis of 3,3-difluoro-2-oxindole derivatives has been developed via copper/B2pin2-catalyzed difluoroacetylation of aniline via C–H activation followed by intramolecular amidation.

scholarly journals Metal-Binding Q-Proline Macrocycles

2021 ◽  
Author(s):  
Justin Northrup ◽  
Jesse Wiener ◽  
Matthew Hurley ◽  
Chun-Feng David Hou ◽  
Taylor Keller ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Functional Groups ◽  
Metal Cation ◽  
Metal Binding ◽  
Metal Cations ◽  
Efficient Synthesis ◽  
Steric Interactions ◽  
Fmoc Spps

Herein, we introduce the efficient synthesis of Q-proline (Q-Pro) based, metal-binding macrocycles (QPM), which can display up to nine functional groups. Synthesis of eight QPM was achieved through standard Fmoc-SPPS and peptoid chemistry. QPM are disordered in the absence of a metal cation, as evidenced by NMR and a crystal structure of <b>QPM-3</b> obtained through racemic crystallization. Addition of metal cations cause these macrocycles to adopt ordered, uniform core structures regardless of the functional groups. Alkylation of QPM allows for addition of reactive functional groups as the final step in a synthesis. Interestingly, the addition of secondary functional groups to the hydantoin amide position (R<sub>2</sub>) converts the proline ring from Cg-endo to Cg-exo, due to steric interactions.

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