Microwave-assisted one-pot synthesis of some new furo[2,3-b]quinolines using potassium carbonate under solvent-free conditions

2007 ◽  
Vol 85 (12) ◽  
pp. 1041-1044 ◽  
Author(s):  
M Raghavendra ◽  
Halehatty S. Bhojya Naik ◽  
Bailure S Sherigara

A rapid, solvent-free microwave-assisted method has been developed for the synthesis of novel furo quinolines. The title compounds were achieved by the reaction between corresponding 2-hydroxy-3-formyl-quinolines (1a–1c) with chloroacetamide, ethylchloroacetate, and phenacylbromide in specially designed microwave (MW) oven for organic synthesis in unsealed borosil vessel in presence of potassium carbonate. In this method, isolation is accomplished by just treating the reaction mixture with water, and products were obtained in high yield. Hence, this method was found to be very effective and ecofriendly. The structure of the newly synthesized compounds has been evaluated on the basis of analytical, IR, 1H NMR, and mass spectral data.Key words: furoquinoline, microwave irradiation, potassium carbonate, solvent-free conditions.

Author(s):  
Mayur K. Vekariya ◽  
Rajesh H. Vekariya ◽  
Nirav N. Barot ◽  
Tauhid A. Shaikh ◽  
Harjinder Kaur ◽  
...  

A library of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were synthesized via Biginelli condensation reaction of β-keto esters, aryl aldehydes and urea/thiourea under solvent-free conditions utilizing nickel nanoparticles under microwave irradiation (CEM Discover). The structures of the all compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and Mass spectral data. Nickel nanoparticles can be recovered and reused five times without loss of their efficiency. Short reaction time, high yield of products and simple workup procedure, solvent-free conditions and reusability of the catalyst are the superior features of this protocol.


2020 ◽  
Vol 17 (6) ◽  
pp. 438-442
Author(s):  
Xiaofang Ma ◽  
Shunxi Li ◽  
Samrat Devaramani ◽  
Guohu Zhao ◽  
Daqian Xu

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.


ChemInform ◽  
2006 ◽  
Vol 37 (32) ◽  
Author(s):  
Mehdi Adib ◽  
Amin Haghighat Jahromi ◽  
Narjes Tavoosi ◽  
Mohammad Mahdavi ◽  
Hamid Reza Bijanzadeh

2020 ◽  
Vol 5 (1) ◽  
pp. 62-67
Author(s):  
Ankita S. Rahate ◽  
Neha A. Shah ◽  
Prashant S. Jadhav ◽  
Sagar T. Sankpal ◽  
Hemant V. Chavan

The silicotungstic acid catalyzed microwave assisted synthesis of substituted 4H-pyrimido[2,1- b]thiazole and 4H-pyrimido[2,1-b]benzothiazole derivatives was achieved by one-pot multi-component reaction of 2-aminothiazole or 2-aminobenzthiazole, aldehyde and ethyl acetoacetate under solventfree condition. A simple, rapid and environmental friendly protocol, good yields and easy work-up are some advantages of this protocol. The structures of the synthesized compounds were established by FT-IR, 1H NMR and mass spectral data.


2008 ◽  
Vol 45 (4) ◽  
pp. 1099-1102 ◽  
Author(s):  
Srinivas Kantevari ◽  
Mahankhali Venu Chary ◽  
Srinivasu V. N. Vuppalapati ◽  
N. Lingaiah

Molecules ◽  
2010 ◽  
Vol 15 (5) ◽  
pp. 3593-3601 ◽  
Author(s):  
Ruoqun Ma ◽  
Jin Zhu ◽  
Jie Liu ◽  
Lili Chen ◽  
Xu Shen ◽  
...  

2006 ◽  
Vol 47 (17) ◽  
pp. 2965-2967 ◽  
Author(s):  
Mehdi Adib ◽  
Amin Haghighat Jahromi ◽  
Narjes Tavoosi ◽  
Mohammad Mahdavi ◽  
Hamid Reza Bijanzadeh

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