Enantioselective synthesis of 1-substituted tetrahydroisoquinoline-1-carboxylic acids
Keyword(s):
The 3,4-dihydroisoquinolinium salt 1 and its enantiomer have been converted readily and stereoselectively into (+)-and (−)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline-1-carboxylic acids. The synthetic route described should be applicable to the enantioselective synthesis of a variety of 1-alkyl- or 1-aryl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acids. The absolute configuration of the amino acid hydrochloride 11 was established to be as depicted in Scheme 2.
2014 ◽
Vol 69
(11-12)
◽
pp. 1088-1096
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2001 ◽
Vol 12
(21)
◽
pp. 2915-2925
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Keyword(s):
2016 ◽
Vol 11
(1)
◽
pp. 1934578X1601100
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