Cree antidiabetic plant extracts display mechanism-based inactivation of CYP3A4

2011 ◽  
Vol 89 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Teresa W. Tam ◽  
Rui Liu ◽  
John T. Arnason ◽  
Anthony Krantis ◽  
William A. Staines ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Picea Mariana ◽  
Picea Glauca ◽  
Pinus Banksiana ◽  
Abies Balsamea ◽  
Cytochrome P450 3A4 ◽  
Cyp3a4 Inhibition ◽  
Kalmia Angustifolia ◽  
Lycopodium Clavatum ◽  
Rhododendron Tomentosum

Seventeen Cree antidiabetic medicinal plants were studied to determine their potential to inhibit cytochrome P450 3A4 (CYP3A4) through mechanism-based inactivation (MBI). The ethanolic extracts of the medicinal plants were studied for their inhibition of CYP3A4 using the substrates testosterone and dibenzylfluorescein (DBF) in high pressure liquid chromatography (HPLC) and microtiter fluorometric assays, respectively. Using testosterone as a substrate, extracts of Alnus incana , Sarracenia purpurea , and Lycopodium clavatum were identified as potent CYP3A4 MBIs, while those from Abies balsamea , Picea mariana , Pinus banksiana , Rhododendron tomentosum , Kalmia angustifolia , and Picea glauca were identified as less potent inactivators. Not unexpectedly, the other substrate, DBF, showed a different profile of inhibition. Only A. balsamea was identified as a CYP3A4 MBI using DBF. Abies balsamea displayed both NADPH- and time-dependence of CYP3A4 inhibition using both substrates. Overall, several of the medicinal plants may markedly deplete CYP3A4 through MBI and, consequently, decrease the metabolism of CYP3A4 substrates including numerous medications used by diabetics.

Short-term effects of cut-to-length versus full-tree harvesting on conifer regeneration in jack pine, mixedwood, and black spruce forests in Manitoba

2004 ◽  
Vol 34 (9) ◽  
pp. 1938-1945 ◽  
Author(s):  
Isobel Waters ◽  
Steven W Kembel ◽  
Jean-François Gingras ◽  
Jennifer M Shay
Keyword(s):  
Picea Mariana ◽  
Picea Glauca ◽  
Pinus Banksiana ◽  
Black Spruce ◽  
Abies Balsamea ◽  
Jack Pine ◽  
Tree Regeneration ◽  
Understorey Vegetation ◽  
Advance Regeneration ◽  
The Impact

This study compares the effects of full-tree versus cut-to-length forest harvesting methods on tree regeneration in jack pine (Pinus banksiana Lamb.), mixedwood (Picea glauca (Moench) Voss – Populus tremuloides Michx. – Abies balsamea (L.) Mill.), and black spruce (Picea mariana (Mill.) BSP) sites in southeastern Manitoba, Canada. We surveyed tree regeneration densities, disturbance characteristics, and understorey vegetation in replicated control and harvested plots in each site type preharvest (1993) and 1 and 3 years postharvest (1994, 1996). In jack pine sites, the full-tree harvest method promoted regeneration of Pinus banksiana through increased disturbance of soil and the moss layer, and decreased slash deposition relative to the cut-to-length method. Conversely, in mixedwood sites the cut-to-length method resulted in less damage to advance regeneration and proved better at promoting postharvest regeneration of Abies balsamea and Picea glauca relative to the full-tree method. In black spruce sites, there were few differences in the impact of the two harvesting methods on regeneration of Picea mariana, which increased in frequency and density after both types of harvesting.

Fungi that cause sapstain in Canadian softwoods

1999 ◽  
Vol 45 (11) ◽  
pp. 914-922 ◽  
Author(s):  
A Uzunovic ◽  
D -Q Yang ◽  
P Gagné ◽  
C Breuil ◽  
L Bernier ◽  
...  
Keyword(s):  
Picea Mariana ◽  
Picea Glauca ◽  
Pinus Banksiana ◽  
Pinus Contorta ◽  
Abies Balsamea ◽  
Forest Products ◽  
Fungal Species ◽  
Forest Products Industry ◽  
Diverse Range ◽  
Commercially Important

The Canadian forest products industry suffers considerable losses due to discoloration caused by sapstain fungi. Although studied for a number of years, the identity, biology, and ecology of these fungi are still only partly understood. To determine which fungi caused stain problems, a detailed survey was conducted at seven selected sawmills across Canada. In summer 1997, fresh logs and lumber were set aside in the mills 1 month prior to sampling for fungi. We excluded bark-beetle-attacked wood and our logs remained free from their attack during storage. Five commercially important softwood species, Abies balsamea (L.) Mill., Picea mariana (Mill.) B.S.P., Picea glauca (Moench) Voss, Pinus contorta Dougl., and Pinus banksiana Lamb., were included in the studies. A total of 1863 isolates were isolated from stained and adjacent areas on test wood, and were identified based on their morphological and physiological characteristics and mating compatibility to 13 different species representing five genera. The most commonly encountered genus, Ophiostoma (97%), was represented by nine species. A more diverse range of fungi was found in logs than in lumber; some species were more frequently isolated from one type of substrate and rarely (or not at all) from the other. No fungal species occurred exclusively in a particular region or wood substrate.Key words: bluestain, lumber, logs, Ophiostoma, Ceratocystis.

The influence of light quality and carbon dioxide enrichment on the growth and physiology of seedlings of three conifer species. I. Growth responses

1996 ◽  
Vol 74 (3) ◽  
pp. 383-390 ◽  
Author(s):  
John Hoddinott ◽  
Rickey Scott
Keyword(s):  
Growth Rates ◽  
Picea Mariana ◽  
Picea Glauca ◽  
Pinus Banksiana ◽  
Light Quality ◽  
Flux Ratio ◽  
Growth Period ◽  
Growth Responses ◽  
Relative Growth ◽  
Relative Growth Rates

Plant growth responds to light quality, as evaluated by the red/far-red (R/FR) quantum flux ratio, and to the level of CO2. Pinus banksiana, Picea mariana and Picea glauca seedlings were raised at 350, 700, or 1050 μL∙L−1 CO2 and high or low R/FR ratios and growth was measured over a 16-week growth period. Far-red rich light enhanced the whole plant and height relative growth rates of Pinus banksiana. The three species showed species specific responses in plant organ relative growth rates and partitioning ratios. On the basis of their biomass partitioning the species would be ranked Pinus banksiana < Picea mariana < Picea glauca for shade tolerance. In commercial operations, seedlings grown for outplanting are selected, in part, on the basis of plant form as described by the stem height/diameter ratio. More desirable ratios were obtained at ambient CO2 concentrations for Pinus banksiana and Picea mariana in red rich light and for Picea glauca in far-red rich light. Keywords: seedling growth, light quality, CO2 enrichment.

Morphological indicators of growth response of coniferous advance regeneration to overstorey removal in the boreal forest

2000 ◽  
Vol 76 (4) ◽  
pp. 633-642 ◽  
Author(s):  
Jean-Claude Ruel ◽  
Christian Messier ◽  
Yves Claveau ◽  
René Doucet ◽  
Phil Comeau
Keyword(s):  
Picea Glauca ◽  
Pinus Banksiana ◽  
Pinus Contorta ◽  
Sudden Change ◽  
Abies Balsamea ◽  
Critical Threshold ◽  
Species Number ◽  
Advance Regeneration ◽  
Tolerant Species ◽  
Shade Tolerant Species

Regeneration of forest stands through the preservation of existing advance regeneration has gained considerable interest in various regions of North America. The effectiveness of this approach relies on the capacity of regeneration to respond positively to overstory removal. Responses of advance regeneration to release is dependent on tree characteristics and site conditions interacting with the degree of physiological shock caused by the sudden change in environmental conditions. This paper presents a review of the literature describing the relationships between morphological indicators and the advance regeneration response to canopy removal. It focuses primarily on the following species: jack pine (Pinus banksiana Lamb.), lodgepole pine (Pinus contorta Dougl. var. latifolia Engelm.), black spruce (Picea mariana (Mill.) B.S.P.), interior spruce (Picea glauca × engelmannii), white spruce (Picea glauca (Moench) Voss), balsam fir (Abies balsamea (L.) Mill.), and subalpine fir (Abies lasiocarpa (Hook.) Nutt). Pre-release height growth has been found to be a good indicator of post-release response for many species. Live-crown ratio also appears to be a good indicator of vigour for shade-tolerant species. The ratio of leader length to length of the longest lateral at the last whorl could serve to describe the degree of suppression before harvest for shade-tolerant species. Number of nodal and internodal branches or buds has been found to be related with vigour for many species. Logging damage has been shown to be an important determinant of seedling response to overstory removal. In contrast, height/diameter ratio has limited value for predicting response to release since it varies with site, species and other factors. No clear relationship between age, height at release and response to release could be demonstrated. This paper also suggests the use of combined indicators and critical threshold values for these indicators. Key words: advance regeneration, careful logging, vigour, clearcutting

scholarly journals Végétation tardiglaciaire et postglaciaire au sud-est du parc des Laurentides, Québec

2011 ◽  
Vol 35 (3) ◽  
pp. 345-359 ◽  
Author(s):  
Claude Labelle ◽  
Pierre J.H. Richard
Keyword(s):  
Picea Mariana ◽  
Picea Glauca ◽  
Abies Balsamea ◽  
Pinus Strobus ◽  
Larix Laricina ◽  
Betula Papyrifera ◽  
Betula Glandulosa

L’analyse pollinique des sédiments de trois lacs situés au sud-est du parc des Laurentides a permis de retracer les étapes de la recolonisation végétale post-wisconsinienne. Celle-ci s’est effectuée selon un schéma assez constant à travers le secteur à l’étude. Au début, la végétation était très ouverte, mais tout de même relativement riche en taxons herbacés et arbustifs. Cette phase initiale de végétation (sous-zone la) fut suivie, après une période de transition (sous-zone 1b), par une végétation luxuriante de type toundra (sous-zone 1c). Celle-ci fut à son tour remplacée par une végétation de type toundra arbustive (sous-zone 1d) où l’on voit s’accroître l’importance de Betula glandulosa et d’autres éléments arbustifs. Avec un certain métachronisme entre les sites, l’afforestation s’est amorcée par l’installation du Populus cf. tremuloïdes (sous-zone 2a) et s’est poursuivie par l’arrivée de Picea mariana (fin de la sous-zone 2a) puis, par celle d’une série d’arbres tels Betula papyrifera, Pinus cf. divaricata, Abies balsamea, Picea glauca et Larix laricina (sous-zone 2b). Pendant cette dernière phase de l’afforestation, l’abondance du pollen d’Alnus cf. crispa dans les spectres est maximale. Il semble qu’au moins mille ans se soient écoulés avant l’arrivée des arbres autres que le Populus cf. tremuloïdes. Par la suite, l’histoire de la végétation forestière (zone 3) a été plutôt monotone. Bien que les diagrammes révèlent des périodes de plus grande abondance de certains taxons (Pinus strobus, Picea mariana, Pinus et. divaricata), la majorité des arbres, présents actuellement dans la région, ont migré très tôt à l’Holocène.

Growth and crown morphological responses of boreal conifer seedlings and saplings with contrasting shade tolerance to a gradient of light and height

2002 ◽  
Vol 32 (3) ◽  
pp. 458-468 ◽  
Author(s):  
Yves Claveau ◽  
Christian Messier ◽  
Philip G Comeau ◽  
K Dave Coates
Keyword(s):  
Picea Glauca ◽  
Pinus Banksiana ◽  
Pinus Contorta ◽  
Morphological Changes ◽  
Abies Balsamea ◽  
Tree Height ◽  
Light Level ◽  
Abies Lasiocarpa ◽  
Morphological Responses ◽  
Picea Species

The effects of gradients in light levels and tree height on growth and crown attributes of six conifer species were studied in eastern and western Canada. Three conifers were studied in British Columbia (Abies lasiocarpa (Hook.) Nutt., Picea glauca (Moench) Voss × Picea engelmannii Parry ex Engelm., and Pinus contorta Dougl. ex Loud. var. latifolia Engelm.), and three in Quebec (Abies balsamea (L.) Mill., Picea glauca, and Pinus banksiana Lamb.). For several growth and morphological parameters, conifers reacted strongly to both an increase in light and tree height. Significant or nearly significant interactions between light classes and height were found for height and diameter growth of most species as well as for many crown attributes for both Abies and Picea. These interactions usually indicated that growth or morphological changes occurred with increasing height from a certain light level. Within a single genus, both eastern and western tree species showed the same overall acclimation to light and height. As generally reported, Pinus species showed less variation in growth and morphological responses to light than Abies and Picea species.

Sign in / Sign up

Export Citation Format

Share Document