scholarly journals High cholesterol diet effects on ischemia–reperfusion injury of the heart

2012 ◽  
Vol 90 (9) ◽  
pp. 1185-1196 ◽  
Author(s):  
Verónica D’Annunzio ◽  
Martín Donato ◽  
Bruno Buchholz ◽  
Virginia Pérez ◽  
Verónica Miksztowicz ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Developed Countries ◽  
Lipid Lowering ◽  
Stunned Myocardium ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Lipid Lowering Effect

Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia–reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, of which hypercholesterolemia is one of the main ones. Therefore, the objective of this review was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia–reperfusion injury associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority were carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins, which apart from exerting a lipid-lowering effect, exert pleiotropic effects providing cardioprotection against ischemia–reperfusion injury. These controversial results concerning the mechanisms of cardioprotection vary according to quality, composition, and time of administration of the high-cholesterol diet, as well as the species used in each experiment. Thus, to compare the results it is necessary to take all of these variables into account, since they can change the obtained results.

Lipid-Lowering Effect of Eriocitrin, the Main Flavonoid in Lemon Fruit, in Rats on a High-Fat and High-Cholesterol Diet

2006 ◽  
Vol 71 (9) ◽  
pp. S633-S637 ◽  
Author(s):  
Yoshiaki Miyake ◽  
Eriko Suzuki ◽  
Satoko Ohya ◽  
Syuichi Fukumoto ◽  
Masanori Hiramitsu ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Lemon Fruit ◽  
Lowering Effect ◽  
Lipid Lowering Effect

scholarly journals Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet

2009 ◽  
Vol 46 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Thamolwan Suanarunsawat ◽  
Watcharaporn Devakul Na Ayutthaya ◽  
Thanapat Songsak ◽  
Suwan Thirawarapan ◽  
Somlak Poungshompoo
Keyword(s):  
Antioxidant Activity ◽  
Essential Oils ◽  
Lipid Lowering ◽  
Ocimum Sanctum ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Lowering Effect ◽  
Lipid Lowering Effect

scholarly journals Lipid lowering and anti-atherosclerotic properties of Tinospora crispa aqueous extract on high-cholesterol diet-induced hyperlipidemic rabbits

2015 ◽  
Vol 14 (34) ◽  
pp. 2604-2610
Author(s):  
M S Zamree ◽  
Safwan K Ihsan ◽  
Kamilah A K Khairul ◽  
Kamal N H Mohd ◽  
M A Rasadah ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol

scholarly journals Effect of lutein on lipid profile in hypercholesterolemic rats

2018 ◽  
Vol 7 (5) ◽  
pp. 859
Author(s):  
Uma Narayanamurthy ◽  
Anandhi M. ◽  
Manimekalai K.
Keyword(s):  
Fatty Infiltration ◽  
Treated Group ◽  
Lipid Lowering ◽  
Ldl Oxidation ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Chow Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Group I

Background: Hyperlipidemia or Dyslipidemia is the major cause of atherosclerosis1 and associated conditions. Low levels of high-density-lipoprotein cholesterol (HDL-C) are the major causes of increased atherogenic risk 1. Aggressive cholesterol reduction in patients with atherosclerotic disease is now the standard of care2. In addition to life style modification, patients with risk factors need lipid lowering drug therapy. The drugs available now do not reduce LDL oxidation, and oxidative stress associated with hyperlipidemia. In recent years, antioxidants have been subjected to epidemiological studies4 that have related their consumption to a reduction in the incidence of oxidative damage related diseases.Methods: Hypercholesterolemia was induced in rats by administration of high cholesterol diet for 30 days in standard rat chow diet. Rats were divided into four groups of six each. Group-I and II with intake of normal diet and High cholesterol diet respectively. Group III and IV are given high cholesterol diet along with Lutein 50mg/kg and Atorvastatin 5mg/kg orally once daily respectively. At the end of 30 days animals were subjected to overnight fasting. Blood samples were drawn by retro-orbital puncture for biochemical analysis. The animals were sacrificed after thiopentone injection and liver and aorta were dissected out and processed for histopathological study and biochemical analysis.Results: Lutein treated group showed even more significant reduction in TBARS levels than the normal control group and Atorvastatin treated group. The efficacy of Lutein in slowing down the atherosclerosis and fatty infiltration of liver is proved in this study.Conclusions: Hence the present study had shown significant hypolipidemic, antiatherogenic and antioxidant effect of Luetin in Hyperlipidemic rats. 

scholarly journals In VivoHypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Swee Keong Yeap ◽  
Boon Kee Beh ◽  
Joan Kong ◽  
Wan Yong Ho ◽  
Hamidah Mohd Yusof ◽  
...  
Keyword(s):  
Water Extract ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
Red Yeast Rice ◽  
Monacolin K ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Red Yeast ◽  
Rice Water

Fermented red yeast rice has been traditionally consumed as medication in Asian cuisine. This study aimed to determine thein vivohypocholesterolemic and antioxidant effects of fermented red yeast rice water extract produced using Malaysian Agricultural Research and Development Institute (MARDI)Monascus purpureusstrains in mice fed with high cholesterol diet. Absence of monacolin-k, lower level ofγ-aminobutyric acid (GABA), higher content of total amino acids, and antioxidant activities were detected in MARDI fermented red yeast rice water extract (MFRYR).In vivoMFRYR treatment on hypercholesterolemic mice recorded similar lipid lowering effect as commercial red yeast rice extract (CRYR) as it helps to reduce the elevated serum liver enzyme and increased the antioxidant levels in liver. This effect was also associated with the upregulation of apolipoproteins-E and inhibition of Von Willebrand factor expression. In summary, MFRYR enriched in antioxidant and amino acid without monacolin-k showed similar hypocholesterolemic effect as CRYR that was rich in monacolin-k and GABA.

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