Lipid lowering effect of S-methyl cysteine sulfoxide from Allium cepa Linn in high cholesterol diet fed rats

Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia–reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related to its development, of which hypercholesterolemia is one of the main ones. Therefore, the objective of this review was to elucidate the effects of a high-cholesterol diet on normal ventricular function and ischemia–reperfusion injury associated phenomenon such as post-ischemic ventricular dysfunction (stunned myocardium). Although there exist many studies considering several aspects of this physiopathological entity, the majority were carried out on normal animals. Thus, experiments carried out on hypercholesterolemic models are controversial, in particular those evaluating different mechanisms of cardioprotection such as ischemic preconditioning and postconditioning, and cardioprotection granted by drugs such as statins, which apart from exerting a lipid-lowering effect, exert pleiotropic effects providing cardioprotection against ischemia–reperfusion injury. These controversial results concerning the mechanisms of cardioprotection vary according to quality, composition, and time of administration of the high-cholesterol diet, as well as the species used in each experiment. Thus, to compare the results it is necessary to take all of these variables into account, since they can change the obtained results.

Download Full-text

Comparison of Lipid Lowering Effect of Aqueous Extract of Cinnamon (Cinnamomum Cassiae) with that of Rosuvastatin on Experimentally Induced Hypercholesterolaemic Rats

TAJ Journal of Teachers Association ◽

10.3329/taj.v31i1.41573 ◽

2019 ◽

Vol 31 (1) ◽

pp. 52-61

Author(s):

Sagia Afrose ◽

Md Ismail Khan ◽

Elisa Omar Eva ◽

Mohammad Imtiaj Mahbub

Keyword(s):

Serum Lipid ◽

Lipid Level ◽

Serum Lipid Level ◽

Lipid Lowering ◽

High Cholesterol Diet ◽

P Value ◽

High Cholesterol ◽

Lowering Effect ◽

Lipid Lowering Effect ◽

Experimentally Induced

Background: Hypercholesterolemia is a condition characterized by very high level of cholesterol in the blood. Too much cholesterol increases risk of developing heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the coronary arteries that supply blood to the heart. A phenolic compound of the cinnamon extract lowers serum lipid level by inhibiting HMG COA reductase & by activation of nuclear receptor peroxisome proliferator activated receptor alpha (PPAR-α). We are trying to evaluate the lipid lowering effect of cinnamon (Cinnamomum cassiae) in comparison with rosuvastatin in hypercholesterolaemic rats. Aim: To find out the lipid lowering effect of aqueous extract of cinnamon (Cinnamomum cassiae) and compare it with a established lipid lowering drug (rosuvastatin) on hypercholesterolaemic rats. Method: This was a experimental study conducted in the department of Pharmacology, Dhaka medical college & Hospital from July 2015 to June 2016. Sample size was 30.The study was designed as 2 parts: Experiment-1 & Experiment -2. Result: Cinnamon produces no statistically significant effect on serum lipid level of healthy rats (P- value >0.05; which is not significant). Cinnamon significantly reduced serum lipid level of high cholesterol diet induced hypercholesterolaemic rats. But, there is statistically significant difference between cinnamon and rosuvastatin lipid lowering effect in high cholesterol diet induced hypercholesterolaemic rats (p value <0.05; which is significant). Conclusion: The study was conducted to find out lipid lowering effect of cinnamon on experimentally induced hypercholesterolaemic rats. The present study found that cinnamon (Cinnamomum cassaiae) significantly lowers serum lipid level in experimentally induced hypercholesterolaemic rats. So cinnamon can be used as alternative lipid lowering agent for its easy availability, cost effectiveness and as well as lack of significant side effects. TAJ 2018; 31(1): 52-61

Download Full-text

Lipid lowering and anti-atherosclerotic properties of Tinospora crispa aqueous extract on high-cholesterol diet-induced hyperlipidemic rabbits

AFRICAN JOURNAL OF BIOTECHNOLOGY ◽

10.5897/ajb2015.14787 ◽

2015 ◽

Vol 14 (34) ◽

pp. 2604-2610

Author(s):

M S Zamree ◽

Safwan K Ihsan ◽

Kamilah A K Khairul ◽

Kamal N H Mohd ◽

M A Rasadah ◽

...

Keyword(s):

Aqueous Extract ◽

Lipid Lowering ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol

Download Full-text

Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet

Vascular Health and Risk Management ◽

10.2147/vhrm.2008.04.01.235 ◽

2008 ◽

Vol 4 (1) ◽

pp. 235-241 ◽

Cited By ~ 26

Author(s):

Oluwatosin A Adaramoye

Keyword(s):

Methanolic Extract ◽

Lipid Lowering ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Vernonia Amygdalina

Download Full-text

Effect of lutein on lipid profile in hypercholesterolemic rats

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20181625 ◽

2018 ◽

Vol 7 (5) ◽

pp. 859

Author(s):

Uma Narayanamurthy ◽

Anandhi M. ◽

Manimekalai K.

Keyword(s):

Fatty Infiltration ◽

Treated Group ◽

Lipid Lowering ◽

Ldl Oxidation ◽

Control Group ◽

High Cholesterol Diet ◽

Chow Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Group I

Background: Hyperlipidemia or Dyslipidemia is the major cause of atherosclerosis1 and associated conditions. Low levels of high-density-lipoprotein cholesterol (HDL-C) are the major causes of increased atherogenic risk 1. Aggressive cholesterol reduction in patients with atherosclerotic disease is now the standard of care2. In addition to life style modification, patients with risk factors need lipid lowering drug therapy. The drugs available now do not reduce LDL oxidation, and oxidative stress associated with hyperlipidemia. In recent years, antioxidants have been subjected to epidemiological studies4 that have related their consumption to a reduction in the incidence of oxidative damage related diseases.Methods: Hypercholesterolemia was induced in rats by administration of high cholesterol diet for 30 days in standard rat chow diet. Rats were divided into four groups of six each. Group-I and II with intake of normal diet and High cholesterol diet respectively. Group III and IV are given high cholesterol diet along with Lutein 50mg/kg and Atorvastatin 5mg/kg orally once daily respectively. At the end of 30 days animals were subjected to overnight fasting. Blood samples were drawn by retro-orbital puncture for biochemical analysis. The animals were sacrificed after thiopentone injection and liver and aorta were dissected out and processed for histopathological study and biochemical analysis.Results: Lutein treated group showed even more significant reduction in TBARS levels than the normal control group and Atorvastatin treated group. The efficacy of Lutein in slowing down the atherosclerosis and fatty infiltration of liver is proved in this study.Conclusions: Hence the present study had shown significant hypolipidemic, antiatherogenic and antioxidant effect of Luetin in Hyperlipidemic rats.

Download Full-text

In VivoHypocholesterolemic Effect of MARDI Fermented Red Yeast Rice Water Extract in High Cholesterol Diet Fed Mice

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2014/707829 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 5

Author(s):

Swee Keong Yeap ◽

Boon Kee Beh ◽

Joan Kong ◽

Wan Yong Ho ◽

Hamidah Mohd Yusof ◽

...

Keyword(s):

Water Extract ◽

Lipid Lowering ◽

High Cholesterol Diet ◽

Red Yeast Rice ◽

Monacolin K ◽

Cholesterol Diet ◽

High Cholesterol ◽

Red Yeast ◽

Rice Water

Fermented red yeast rice has been traditionally consumed as medication in Asian cuisine. This study aimed to determine thein vivohypocholesterolemic and antioxidant effects of fermented red yeast rice water extract produced using Malaysian Agricultural Research and Development Institute (MARDI)Monascus purpureusstrains in mice fed with high cholesterol diet. Absence of monacolin-k, lower level ofγ-aminobutyric acid (GABA), higher content of total amino acids, and antioxidant activities were detected in MARDI fermented red yeast rice water extract (MFRYR).In vivoMFRYR treatment on hypercholesterolemic mice recorded similar lipid lowering effect as commercial red yeast rice extract (CRYR) as it helps to reduce the elevated serum liver enzyme and increased the antioxidant levels in liver. This effect was also associated with the upregulation of apolipoproteins-E and inhibition of Von Willebrand factor expression. In summary, MFRYR enriched in antioxidant and amino acid without monacolin-k showed similar hypocholesterolemic effect as CRYR that was rich in monacolin-k and GABA.

Download Full-text

Comparison of the Protective Effects of Individual Components of Particulatedtrans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits

BioMed Research International ◽

10.1155/2017/7212985 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 5

Author(s):

Shérrira M. Garavelo ◽

Maria de Lourdes Higuchi ◽

Jaqueline J. Pereira ◽

Marcia M. Reis ◽

Joyce T. Kawakami ◽

...

Keyword(s):

Mycoplasma Pneumoniae ◽

Abdominal Aorta ◽

Oxidized Ldl ◽

Rabbit Model ◽

Lipid Lowering ◽

High Cholesterol Diet ◽

Protective Effects ◽

Cholesterol Diet ◽

High Cholesterol ◽

Plaque Area

Previous studies showed the presence ofMycoplasma pneumoniae(M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined withtrans-Sialidase (TS), to combat MPs andMycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS. Lipid profile and quantification of MPs positive forMycoplasma pneumoniaeand oxidized LDL antigens were carried out. Aortas and organs were then histologically analyzed. PTCTS reduced circulating MPs positive forMycoplasma pneumoniaeand oxidized LDL antigens, reduced the plaque area in the abdominal aorta, and caused positive remodeling of the ascendant aorta. PTC caused positive remodeling and reduced plaque area in the abdominal aorta; however, TS had a lipid lowering effect. PTCTS components combined were more effective against atherosclerosis than individual components. Our data reinforce the infectious theory of atherosclerosis and underscore the potential role of circulating MPs. Therefore, the removal ofMycoplasma-derived MPs could be a new therapeutic approach in the treatment of atherosclerosis.

Download Full-text