Role of quercetin in vascular physiology

2012 ◽  
Vol 90 (12) ◽  
pp. 1652-1657 ◽  
Author(s):  
Salvatore Chirumbolo
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Protective Effect ◽  
Canadian Journal ◽  
Human Studies ◽  
Redox Ratio ◽  
Vascular Physiology ◽  
Vascular Protective Effect

A recent paper in the Canadian Journal of Physiology and Pharmacology has shown that quercetin has a vascular protective effect associated with eNOS up-regulation, blood GSH redox ratio, and reduction of oxidative stress. Recent reports have recommended the consumption of quercetin, as it may contribute to a reduction in the risk of cardiovascular disease. However, the mechanisms by which quercetin exerts its action have not been fully elucidated. The majority of these mechanisms have been identified with models using animals treated with quercetin, and relatively few have been corroborated in human studies, which indicates the need for further investigation.

Cardiovascular disease in aging and the role of oxidative stress

Aging ◽  
2020 ◽  
pp. 19-35
Author(s):  
Lucie Orliaguet ◽  
Vinood B. Patel ◽  
Victor R. Preedy ◽  
Fawaz Alzaid
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease

scholarly journals New Insights into the Role of Oxidative Stress in Onset of Cardiovascular Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-2 ◽  
Author(s):  
Adrian Doroszko ◽  
Piotr Dobrowolski ◽  
Aneta Radziwon-Balicka ◽  
Robert Skomro
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease

scholarly journals Physiological, Biochemical and Molecular Role of Oxidative Stress in Cardiovascular Disease: A Comprehensive Study

2016 ◽  
Vol 6 (1) ◽  
pp. 1-16
Author(s):  
Sanjay Mishra ◽  
Amit Kumar Mani ◽  
Abbas Ali Mahdi
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Comprehensive Study

scholarly journals Klotho protects chondrocyte viability via FOXO1/3 in osteoarthritis

2021 ◽  
Vol 20 (9) ◽  
pp. 1961-1968
Author(s):  
Wei Wei ◽  
Liefeng Ji ◽  
Wanli Duan ◽  
Jiang Zhu
Keyword(s):  
Oxidative Stress ◽  
Survival Rate ◽  
Protective Effect ◽  
Collagen I ◽  
Inflammatory Factors ◽  
Ros Production ◽  
Chondrocyte Viability ◽  
Tnf Α ◽  
Collagen Ii

Purpose: To investigate the effect of Klotho and FOXO1/3 on the CH viability in OA.Methods: The survival rate of CHs, Klotho and FOXO1/3 protein expression, and ROS production were measured in the OA cartilages of different degenerative phases. H2O2 was also used to injure CHs, and the cell viability, Klotho and FOXO1/3 expressions, as well as ROS levels were investigated to clarify the effect of exogenic Klotho on the injured CHs. Additionally, in order to verify the role of FOXO1/3 in Klotho-treated CHs, SOD2, GPX1, inflammatory factors, collagen I/II, SOX9, and Runx-2 levels were analyzed by silencing FOXO1 and FOXO3 expression via siRNA transfection.Results: Klotho and FOXO1/3 expressions significantly decreased, and ROS production increased in severely human OA cartilage (p <0.05). Besides, H2O2 affected CHs viability with the suppression of Klotho and FOXO1/3 expression but ROS production was elevated. Exogenic Klotho application partly reversed the injury caused by H2O2. Furthermore, Klotho treatment of the injured CHs contributed to SOD2 and GPX1 expressions, and suppressed IL-1β, IL-6, TNF-α and MMP-13 production, resulting in  the upregulation of collagen II and SOX9 as well as downregulation of collagen I and Runx-2. However, the protective effect of Klotho was weakened by FOXO1 and FOXO3 gene silencing.Conclusion: Klotho protects CHs viability by suppressing oxidative stress and inflammation, which is associated with the mediation of FOXO1 and FOXO3. These findings provide new insights into the treatment of OA.

scholarly journals The Role of Antioxidants in the Management of Obsessive-Compulsive Disorder

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Fatemeh Baratzadeh ◽  
Sepideh Elyasi ◽  
Amir Hooshang Mohammadpour ◽  
Sofia Salari ◽  
Amirhossein Sahebkar
Keyword(s):  
Oxidative Stress ◽  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Human Studies ◽  
Large Sample Size ◽  
Antioxidant Treatment ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a chronic neuropsychiatric disorder that has a significant effect on the quality of life. The most effective treatment for OCD is the combination of selective serotonin reuptake inhibitors (SSRI) with cognitive behavior therapy (CBT). However, several adverse effects have been linked with this usual pharmacotherapy, and it is unsuccessful in many patients. The exact pathophysiology of OCD is not completely known, though the role of oxidative stress in its pathogenesis has been proposed recently. This review presents an overview of animal and human studies of antioxidant treatment for OCD. The use of antioxidants against oxidative stress is a novel treatment for several neurodegenerative and neuropsychiatric disorders. Among antioxidants, NAC was one of the most studied drugs on OCD, and it showed a significant improvement in OCD symptoms. Thus, antioxidants could be promising as an adjuvant treatment for OCD. However, a limited number of human studies are conducted on these agents, and for better judgment, human studies with a large sample size are necessary.

scholarly journals The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness

Redox Biology ◽  
2020 ◽  
Vol 37 ◽  
pp. 101585 ◽  
Author(s):  
Huige Li ◽  
Ning Xia
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Social Isolation
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