vascular protective effect
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Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 128 ◽  
Author(s):  
Roberta Cazzola ◽  
Matteo Della Porta ◽  
Sara Castiglioni ◽  
Luciano Pinotti ◽  
Jeanette A.M. Maier ◽  
...  

N-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) seem to prevent endothelial dysfunction, a crucial step in atherogenesis, by modulating the levels of vasoactive molecules and by influencing Na,K-ATPase activity of vascular myocytes. The activity of endothelial Na,K-ATPase controls the ionic homeostasis of the neighboring cells, as well as cell function. However, controversy exists with respect to the vascular protective effect of EPA and DHA. We argue that this dispute might be due to the use of different concentrations of EPA and DHA in different studies. Therefore, this study was designed to define an optimal concentration of EPA and DHA to investigate endothelial function. For this purpose, human endothelial cells were exposed for 24 h to different concentrations of DHA or EPA (0–20 μM) to study membrane fluidity, peroxidation potential and Na,K-ATPase activity. EPA and DHA were linearly incorporated and this incorporation was mirrored by the linear increase of unsaturation index, membrane fluidity, and peroxidation potential. Na,K-ATPase activity peaked at 3.75 μM of EPA and DHA and then gradually decreased. It is noteworthy that DHA effects were always more pronounced than EPA. Concluding, low concentrations of EPA and DHA minimize peroxidation sensitivity and optimize Na,K-ATPase activity.



Life Sciences ◽  
2019 ◽  
Vol 216 ◽  
pp. 59-66 ◽  
Author(s):  
Yan Lei ◽  
Xiaoyong Peng ◽  
Tao Li ◽  
Liangming Liu ◽  
Guangming Yang


Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S37-S38
Author(s):  
P. Li ◽  
S. Fan ◽  
K. Lee ◽  
C. Chen ◽  
C. Wang ◽  
...  


2014 ◽  
Vol 112 (07) ◽  
pp. 164-175 ◽  
Author(s):  
Shabir H. Qureshi ◽  
Likui Yang ◽  
Peyman Dinarvand ◽  
Alireza R. Rezaie

SummaryAntithrombin (AT) is a heparin-binding serpin in plasma which regulates the proteolytic activity of procoagulant proteases of the clotting cascade. In addition to being an anticoagulant, AT also exhibits antiinflammatory activities when it binds to cell surface heparan sulfate proteoglycans (HSPGs) on the endothelium via its basic residues of D-helix to elicit intracellular signalling responses. By contrast to AT, α1-proteinase inhibitor (α1-PI) is a non-heparin-binding serpin that exhibits very slow reactivity with coagulation proteases and possesses no HSPG-dependent antiinflammatory properties. To determine whether the antiinflammatory signaling specificity of AT can be transferred to α1-PI, we replaced the D-helix of human α1-PI with the corresponding sequence of human AT and expressed the chimeric serpin α1-PI/D-helix) in a bacterial expression system. High molecular weight heparin bound to α1-PI/D-helix and accelerated the inhibition of thrombin by the serpin mutant by a template mechanism reminiscent of the cofactor effect of heparin on inhibition of thrombin by AT. Like AT, α1-PI/D-helix exhibited antiinflammatory properties in both cellular and animal models. Thus, α1-PI/D-helix inhibited the barrier-disruptive effect of proinflammatory cytokines and inhibited the activation of nuclear factor-kB transcription factor in lipopolysaccharide-stimulated endothelial cells by a concentration-dependent manner. Furthermore, the chimeric serpin reduced lipopolysaccharide-mediated lethality, elicited a vascular protective effect and inhibited infiltration of activated leukocytes to the peritoneal cavity of mice in an HMGB1-mediated inflammatory model. These results suggest that grafting the D-helix of AT to α1-PI confers antiinflammatory properties on the serpin and that the chimeric serpin may have therapeutic utility for treating inflammatory disorders.



2012 ◽  
Vol 90 (12) ◽  
pp. 1652-1657 ◽  
Author(s):  
Salvatore Chirumbolo

A recent paper in the Canadian Journal of Physiology and Pharmacology has shown that quercetin has a vascular protective effect associated with eNOS up-regulation, blood GSH redox ratio, and reduction of oxidative stress. Recent reports have recommended the consumption of quercetin, as it may contribute to a reduction in the risk of cardiovascular disease. However, the mechanisms by which quercetin exerts its action have not been fully elucidated. The majority of these mechanisms have been identified with models using animals treated with quercetin, and relatively few have been corroborated in human studies, which indicates the need for further investigation.



Hypertension ◽  
2011 ◽  
Vol 57 (5) ◽  
Author(s):  
Dhiman Maitra ◽  
Jashoman Banerjee ◽  
Faten Shaeib ◽  
Carlos Eduardo A. Souza ◽  
Husam M. Abu-Soud


Hypertension ◽  
2011 ◽  
Vol 57 (5) ◽  
Author(s):  
Rita Rezzani ◽  
Enzo Porteri ◽  
Carolina De Ciuceis ◽  
Francesca Bonomini ◽  
Luigi F. Rodella ◽  
...  


2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Yun Jung Lee ◽  
Deok Ho Choi ◽  
Sun Mi Hwang ◽  
You Mee Ahn ◽  
Jin Sook Kim ◽  
...  


2006 ◽  
Vol 13 (6) ◽  
pp. 489-497 ◽  
Author(s):  
Dhananjay K. Kaul ◽  
Rahn Kollander ◽  
Hemchandra Mahaseth ◽  
Xiao-Du Liu ◽  
Anna Solovey ◽  
...  


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