The effect of temperature on the responses to electrical stimulation of the isolated cerebral cortex of the cat
The effect of temperature over the range 28 to 37 °C was studied on the electrically induced responses in the neuronally isolated cortex of the cat. The positive burst response (PBR) was found to be insensitive to a fall in temperature with no change in threshold, although the duration of the response was increased at low temperature. The threshold for inducing the epileptiform afterdischarge (EAD) remained constant in some animals but decreased in half of the animals studied. As the temperature was lowered, the amplitude of the EAD decreased while the frequency increased. The epileptiform sustaining response (ESR) on the other hand was markedly sensitive to temperature and disappeared around 32 °C. The differential effect of temperature upon the PBR and ESR, which have similar parameters for their production, provides further evidence for the separate identity of the two responses.