Vasoactive intestinal polypeptide excitation of central neurons

1978 ◽  
Vol 56 (2) ◽  
pp. 337-340 ◽  
Author(s):  
J. W. Phillis ◽  
J. R. Kirkpatrick ◽  
S. I. Said
Keyword(s):  
Spinal Cord ◽  
Cerebral Cortex ◽  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Cortical Neurons ◽  
Dorsal Root ◽  
Central Neurons ◽  
Sensory Motor ◽  
Repeated Applications ◽  
Intestinal Polypeptide

Vasoactive intestinal polypeptide (VIP) was tested on neurons in the rat sensory motor cerebral cortex and on the isolated hemisected toad spinal cord. Iontophoretically applied VIP excited deep, spontaneously active cortical neurons, including identified corticospinal neurons. The excitation had a latency of onset varying from several seconds to over 1 min and often lasted for a minute or longer after cessation of the application. Desensitization of the effect occurred with repeated applications. VIP caused a depolarization of motoneurons and dorsal root terminals in the isolated amphibian spinal cord. Threshold for this effect was about 10−6 M. The effects of VIP on both preparations were comparable with those of another peptide, substance P.

scholarly journals Bombesin-Like, Substance P and Vasoactive Intestinal Polypeptide Receptors in Fetal Cortical Homografts to Host Cortex and Spinal Cord

1989 ◽  
Vol 1 (3-4) ◽  
pp. 105-112 ◽  
Author(s):  
Terry W. Moody ◽  
Reina L. Getz ◽  
William J. Goldberg ◽  
Jerald J. Bernstein
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Peptide Receptors ◽  
Adult Rat ◽  
Graft Donor ◽  
Intestinal Polypeptide

Neuropeptide receptors were visualized in homografts of fetal cortex (E14) into adult rat cortex (immediate or 7 day delay) and spinal cord usingin vitroautoradiographic techniques to explore the expression of peptide receptors in the same graft tissue in different central nervous system implantation sites. Receptors for bombesin (BN)-like peptides developed in the grafts by 3 weeks postimplantation regardless of location or age of implantation pocket in host. After 4 weeks, the density of BN receptors was confined to the graft. In grafts to spinal cord, however, high densities of BN-like receptors were not confined to the graft but were distributed throughout the spinal cord. In contrast, the density of vasoactive intestinal polypeptide (VIP) and substance P (SP) receptors was moderate and low to undetectable in the fetal grafts. The development of the peptide receptors studied was graft donor tissue specific since they were not altered by central nervous system implantation site.

Survey of distribution of substance P, vasoactive intestinal polypeptide, cholecystokinin, neurotensin, Met-enkephalin, bombesin and PHI in the spinal cord of cat, dog, sloth and monkey

Peptides ◽  
1988 ◽  
Vol 9 (2) ◽  
pp. 357-372 ◽  
Author(s):  
Tony L. Yaksh ◽  
Sandra R. Michener ◽  
Jane E. Bailey ◽  
Gail J. Harty ◽  
Darlene L. Lucas ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Vasoactive Intestinal Polypeptide ◽  
Intestinal Polypeptide

Distribution of substance P-like immunoreactivity in the spinal cord and dorsal root ganglia of the human foetus and infant

Neuroscience ◽  
1983 ◽  
Vol 10 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Y. Charnay ◽  
C. Paulin ◽  
J.-A. Chayvialle ◽  
P.M. Dubois
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Human Foetus
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