Effect of changes in blood flow, norepinephrine, and pH on oxygen uptake by resting skeletal muscle

1980 ◽  
Vol 58 (1) ◽  
pp. 93-96 ◽  
Author(s):  
C. K. Chapler ◽  
W. N. Stainsby ◽  
L. B. Gladden
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Muscle Blood Flow ◽  
Sampling Period ◽  
Low Flow ◽  
Muscle Oxygen ◽  
Norepinephrine Infusion ◽  
Infusion Of Norepinephrine ◽  
Muscle Oxygen Uptake

The purpose of this study was to examine the effects of norepinephrine infusion alone and during alkalosis on oxygen uptake in the dog gastrocnemius-plantaris muscle group under conditions of constant muscle blood flow. The animals were not cold acclimatized. Blood flow was pump controlled, alkalosis was produced by hyperventilation, and norepinephrine was infused intravenously at a rate of 1–1.5 μg/kg per minute. Alkalosis had no effect either alone or in combination with changes in blood flow. Similarly, changing blood flow from a low (0.10 ± 0.02 mL/g muscle per minute (mean ± SE)) to a high (0.34 ± 0.04 mL/g muscle per minute) rate did not alter resting oxygen uptake. Norepinephrine caused an average increase of about 30% in resting muscle oxygen uptake which was sustained for the 15-min sampling period during low flow - norepinephrine infusion and during the low and high blood flow - norepinephrine - alkalosis sampling periods. Norepinephrine infusion during the period of high muscle blood flow without alkalosis resulted in a transient increase followed by a decrease in muscle oxygen uptake. The data demonstrated that infusion of norepinephrine increased skeletal muscle oxygen uptake in "non-cold-acclimatized" dogs at low constant muscle blood flow. Further, without alkalosis, the norepinephrine effect at high flow was transient.

Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition

2011 ◽  
Vol 300 (4) ◽  
pp. H1510-H1517 ◽  
Author(s):  
Heinonen Ilkka ◽  
Saltin Bengt ◽  
Kemppainen Jukka ◽  
Hannu T. Sipilä ◽  
Oikonen Vesa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Muscle Blood Flow ◽  
Arterial Infusion ◽  
Skeletal Muscle Blood Flow ◽  
Muscle Oxygen ◽  
Resting Muscle ◽  
Muscle Oxygen Uptake

The aim of the present study was to determine the effect of nitric oxide and prostanoids on microcirculation and oxygen uptake, specifically in the active skeletal muscle by use of positron emission tomography (PET). Healthy males performed three 5-min bouts of light knee-extensor exercise. Skeletal muscle blood flow and oxygen uptake were measured at rest and during the exercise using PET with H2O15 and 15O2 during: 1) control conditions; 2) nitric oxide synthase (NOS) inhibition by arterial infusion of NG-monomethyl-l-arginine (l-NMMA), and 3) combined NOS and cyclooxygenase (COX) inhibition by arterial infusion of l-NMMA and indomethacin. At rest, inhibition of NOS alone and in combination with indomethacin reduced ( P < 0.05) muscle blood flow. NOS inhibition increased ( P < 0.05) limb oxygen extraction fraction (OEF) more than the reduction in muscle blood flow, resulting in an ∼20% increase ( P < 0.05) in resting muscle oxygen consumption. During exercise, muscle blood flow and oxygen uptake were not altered with NOS inhibition, whereas muscle OEF was increased ( P < 0.05). NOS and COX inhibition reduced ( P < 0.05) blood flow in working quadriceps femoris muscle by 13%, whereas muscle OEF and oxygen uptake were enhanced by 51 and 30%, respectively. In conclusion, by specifically measuring blood flow and oxygen uptake by the use of PET instead of whole limb measurements, the present study shows for the first time in humans that inhibition of NO formation enhances resting muscle oxygen uptake and that combined inhibition of NOS and COX during exercise increases muscle oxygen uptake.

Low blood flow at onset of moderate-intensity exercise does not limit muscle oxygen uptake

2010 ◽  
Vol 298 (3) ◽  
pp. R843-R848 ◽  
Author(s):  
Michael Nyberg ◽  
Stefan P. Mortensen ◽  
Bengt Saltin ◽  
Ylva Hellsten ◽  
Jens Bangsbo
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Oxygen Delivery ◽  
Initial Phase ◽  
Muscle Blood Flow ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 ± 1 W, mean ± SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase ( NG-monomethyl-l-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25–50% lower ( P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O2 difference) was higher ( P < 0.05) in DB than in Con (5 s: 127 ± 3 vs. 56 ± 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller ( P < 0.05) during exercise in DB than in Con (5 s: 59 ± 12 vs. 262 ± 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise.

Oxygen uptake and blood flow in canine skeletal muscle during moderate and severe anemia

1983 ◽  
Vol 61 (2) ◽  
pp. 178-182 ◽  
Author(s):  
C. K. Chapler ◽  
S. M. Cain
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Oxygen Transport ◽  
Muscle Blood Flow ◽  
Whole Body ◽  
Arterial Oxygen ◽  
Acute Anemia ◽  
Moderate Anemia ◽  
The Mean

The metabolic and cardiovascular adjustments of the whole body and skeletal muscle were studied during moderate and severe acute anemia. In 15 anesthetized dogs, venous outflow from the gastrocnemius–plantaris muscle group was isolated. Cardiac output [Formula: see text], muscle blood flow [Formula: see text], total body and muscle oxygen uptake [Formula: see text] were determined during a control period, and at 30 and 60 min of either (i) moderate anemia (n = 8) in which the mean hematocrit (Hct) was 25% or (ii) progressive anemia (n = 7) in which the mean Hct values were 25% at 30 min and 16% at 60 min of anemia. Muscle [Formula: see text], [Formula: see text], and [Formula: see text] were increased in both groups at 30 min of anemia. By 60 min, [Formula: see text] and [Formula: see text] declined to preanemic control values in the moderate anemia group; whole body [Formula: see text] was maintained at the control level. Arterial oxygen transport was the same in the two groups at both 30 and 60 min of anemia despite the difference in Hct at 60 min. Muscle [Formula: see text] showed a further and similar rise in both groups between 30 and 60 min of anemia. These data show that the rise in muscle [Formula: see text] during acute anemia was not directly proportional to the degree of the hematocrit reduction. Further, the findings suggest that the muscle [Formula: see text] response was related to the decrease in arterial oxygen transport.

scholarly journals Skeletal Muscle Oxygen Uptake Dynamics during the Exercise Off‐Transient

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Brad J Behnke ◽  
Leonardo F Ferreira ◽  
Timothy I Musch ◽  
David C Poole
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

scholarly journals Cytochrome P450 2C9 plays an important role in the regulation of exercise‐induced skeletal muscle blood flow and oxygen uptake in humans

2003 ◽  
Vol 546 (1) ◽  
pp. 307-314 ◽  
Author(s):  
Thore Hillig ◽  
Peter Krustrup ◽  
Ingrid Fleming ◽  
Takuya Osada ◽  
Bengt Saltin ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Cytochrome P450 ◽  
Oxygen Uptake ◽  
Muscle Blood Flow ◽  
Cytochrome P450 2C9 ◽  
Skeletal Muscle Blood Flow ◽  
Exercise Induced

Skeletal muscle oxygen uptake in obese patients: functional evaluation by knee-extension exercise

2013 ◽  
Vol 113 (8) ◽  
pp. 2125-2132 ◽  
Author(s):  
Stefano Lazzer ◽  
Desy Salvadego ◽  
Simone Porcelli ◽  
Enrico Rejc ◽  
Fiorenza Agosti ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Knee Extension ◽  
Functional Evaluation ◽  
Obese Patients ◽  
Muscle Oxygen ◽  
Knee Extension Exercise ◽  
Muscle Oxygen Uptake

Monitoring muscle oxygenation after eccentric exercise-induced muscle damage using near-infrared spectroscopy

2008 ◽  
Vol 33 (4) ◽  
pp. 743-752 ◽  
Author(s):  
Sirous Ahmadi ◽  
Peter J. Sinclair ◽  
Nasim Foroughi ◽  
Glen M. Davis
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Infrared Spectroscopy ◽  
Oxygen Uptake ◽  
Oxygen Saturation ◽  
Eccentric Exercise ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Muscle Oxygenation ◽  
Muscle Oxygen

Eccentric exercise (EE), a common type of muscular activity whereby muscles lengthen and contract simultaneously, is associated with higher levels of force but may also evoke muscle damage. We investigated the hypothesis that unaccustomed EE might impair muscle oxygenation and muscle blood flow in healthy adults. Ten healthy males performed a bout of 70 maximal eccentric contractions of the elbow flexors. Before and after EE on day 1 and over the next 6 days, maximum voluntary isometric torque (MVT), serum creatine kinase (CK), and the changes in muscle oxygen saturation, blood flow, and oxygen uptake (using near-infrared spectroscopy) within the biceps brachii were assessed. MVT decreased, whereas muscle soreness and CK increased after EE (p < 0.05). Mean resting oxygen saturation increased by 22% after acute EE, and remained elevated by 5%–9% for the following 6 days. During isometric contractions, significant decreases were observed in oxygen desaturation and re-saturation kinetics after EE and these declines were also significantly prevalent over the following 6 days. Both muscle blood flow and oxygen uptake increased significantly after acute EE, but recovered on the next day. This study revealed some prolonged alterations in muscle oxygenation at rest and during exercise after EE, which might be due to a decrease in muscle oxygen consumption, an increase in oxygen delivery, and (or) a combination of both. However, both oxygen consumption and blood flow recovered within 24 h after the eccentric exercise session, and therefore, the reason(s) for the changes in tissue oxygen saturation remain unknown.

scholarly journals Recovery dynamics of skeletal muscle oxygen uptake during the exercise off-transient

2009 ◽  
Vol 168 (3) ◽  
pp. 254-260 ◽  
Author(s):  
Brad J. Behnke ◽  
Leonardo F. Ferreira ◽  
P.J. McDonough ◽  
Timothy I. Musch ◽  
David C. Poole
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Muscle Oxygen ◽  
Recovery Dynamics ◽  
Muscle Oxygen Uptake

scholarly journals Slowed muscle oxygen uptake kinetics with raised metabolism are not dependent on blood flow or recruitment dynamics

2014 ◽  
Vol 592 (8) ◽  
pp. 1857-1871 ◽  
Author(s):  
Rob C. I. Wüst ◽  
James R. McDonald ◽  
Yi Sun ◽  
Brian S. Ferguson ◽  
Matthew J. Rogatzki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Oxygen Uptake ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake
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