scholarly journals Intense interval training enhances human skeletal muscle oxygen uptake in the initial phase of dynamic exercise at high but not at low intensities

2004 ◽  
Vol 559 (1) ◽  
pp. 335-345 ◽  
Author(s):  
Peter Krustrup ◽  
Ylva Hellsten ◽  
Jens Bangsbo
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Initial Phase ◽  
Human Skeletal Muscle ◽  
Interval Training ◽  
Dynamic Exercise ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

scholarly journals Muscle oxygen uptake and energy turnover during dynamic exercise at different contraction frequencies in humans

2001 ◽  
Vol 536 (1) ◽  
pp. 261-271 ◽  
Author(s):  
Richard A. Ferguson ◽  
Derek Ball ◽  
Peter Krustrup ◽  
Per Aagaard ◽  
Michael Kjær ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Dynamic Exercise ◽  
Energy Turnover ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

scholarly journals Skeletal Muscle Oxygen Uptake Dynamics during the Exercise Off‐Transient

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Brad J Behnke ◽  
Leonardo F Ferreira ◽  
Timothy I Musch ◽  
David C Poole
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

Skeletal muscle oxygen uptake in obese patients: functional evaluation by knee-extension exercise

2013 ◽  
Vol 113 (8) ◽  
pp. 2125-2132 ◽  
Author(s):  
Stefano Lazzer ◽  
Desy Salvadego ◽  
Simone Porcelli ◽  
Enrico Rejc ◽  
Fiorenza Agosti ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Knee Extension ◽  
Functional Evaluation ◽  
Obese Patients ◽  
Muscle Oxygen ◽  
Knee Extension Exercise ◽  
Muscle Oxygen Uptake

scholarly journals Recovery dynamics of skeletal muscle oxygen uptake during the exercise off-transient

2009 ◽  
Vol 168 (3) ◽  
pp. 254-260 ◽  
Author(s):  
Brad J. Behnke ◽  
Leonardo F. Ferreira ◽  
P.J. McDonough ◽  
Timothy I. Musch ◽  
David C. Poole
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Muscle Oxygen ◽  
Recovery Dynamics ◽  
Muscle Oxygen Uptake

scholarly journals Blood flow and muscle oxygen uptake at the onset and end of moderate and heavy dynamic forearm exercise

2001 ◽  
Vol 280 (6) ◽  
pp. R1741-R1747 ◽  
Author(s):  
Mireille C. P. Van Beekvelt ◽  
J. Kevin Shoemaker ◽  
Michael E. Tschakovsky ◽  
Maria T. E. Hopman ◽  
Richard L. Hughson
Keyword(s):  
Blood Flow ◽  
Oxygen Uptake ◽  
Venous Blood ◽  
Recovery Period ◽  
Dynamic Exercise ◽  
Moderate Intensity ◽  
Moderate Exercise ◽  
Muscle Oxygen ◽  
Forearm Exercise ◽  
Muscle Oxygen Uptake

We hypothesized that forearm blood flow (FBF) during moderate intensity dynamic exercise would meet the demands of the exercise and that postexercise FBF would quickly recover. In contrast, during heavy exercise, FBF would be inadequate causing a marked postexercise hyperemia and sustained increase in muscle oxygen uptake (V˙o 2musc). Six subjects did forearm exercise (1-s contraction/relaxation, 1-s pause) for 5 min at 25 and 75% of peak workload. FBF was determined by Doppler ultrasound, and O2 extraction was estimated from venous blood samples. In moderate exercise, FBF andV˙o 2musc increased within 2 min to steady state. Rapid recovery to baseline suggested adequate O2supply during moderate exercise. In contrast, FBF was not adequate during heavy dynamic exercise. Immediately postexercise, there was an ∼50% increase in FBF. Furthermore, we observed for the first time in the recovery period an increase inV˙o 2musc above end-exercise values. During moderate exercise, O2 supply met requirements, but with heavy forearm exercise, inadequate O2 supply during exercise caused accumulation of a large O2 deficit that was repaid during recovery.

Low blood flow at onset of moderate-intensity exercise does not limit muscle oxygen uptake

2010 ◽  
Vol 298 (3) ◽  
pp. R843-R848 ◽  
Author(s):  
Michael Nyberg ◽  
Stefan P. Mortensen ◽  
Bengt Saltin ◽  
Ylva Hellsten ◽  
Jens Bangsbo
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Oxygen Delivery ◽  
Initial Phase ◽  
Muscle Blood Flow ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

The effect of low blood flow at onset of moderate-intensity exercise on the rate of rise in muscle oxygen uptake was examined. Seven male subjects performed a 3.5-min one-legged knee-extensor exercise bout (24 ± 1 W, mean ± SD) without (Con) and with (double blockade; DB) arterial infusion of inhibitors of nitric oxide synthase ( NG-monomethyl-l-arginine) and cyclooxygenase (indomethacin) to inhibit the synthesis of nitric oxide and prostanoids, respectively. Leg blood flow and leg oxygen delivery throughout exercise was 25–50% lower ( P < 0.05) in DB compared with Con. Leg oxygen extraction (arteriovenous O2 difference) was higher ( P < 0.05) in DB than in Con (5 s: 127 ± 3 vs. 56 ± 4 ml/l), and leg oxygen uptake was not different between Con and DB during exercise. The difference between leg oxygen delivery and leg oxygen uptake was smaller ( P < 0.05) during exercise in DB than in Con (5 s: 59 ± 12 vs. 262 ± 39 ml/min). The present data demonstrate that muscle blood flow and oxygen delivery can be markedly reduced without affecting muscle oxygen uptake in the initial phase of moderate-intensity exercise, suggesting that blood flow does not limit muscle oxygen uptake at the onset of exercise. Additionally, prostanoids and/or nitric oxide appear to play important roles in elevating skeletal muscle blood flow in the initial phase of exercise.

Reduced Skeletal Muscle Oxygen Uptake and Reduced  -Cell Function: Two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes

Diabetes Care ◽  
2003 ◽  
Vol 26 (7) ◽  
pp. 2126-2132 ◽  
Author(s):  
C. Thamer ◽  
M. Stumvoll ◽  
A. Niess ◽  
O. Tschritter ◽  
M. Haap ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Cell Function ◽  
Muscle Oxygen ◽  
Normal Glucose Tolerant ◽  
Normal Glucose ◽  
Glucose Tolerant ◽  
Muscle Oxygen Uptake

Effect of changes in blood flow, norepinephrine, and pH on oxygen uptake by resting skeletal muscle

1980 ◽  
Vol 58 (1) ◽  
pp. 93-96 ◽  
Author(s):  
C. K. Chapler ◽  
W. N. Stainsby ◽  
L. B. Gladden
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Muscle Blood Flow ◽  
Sampling Period ◽  
Low Flow ◽  
Muscle Oxygen ◽  
Norepinephrine Infusion ◽  
Infusion Of Norepinephrine ◽  
Muscle Oxygen Uptake

The purpose of this study was to examine the effects of norepinephrine infusion alone and during alkalosis on oxygen uptake in the dog gastrocnemius-plantaris muscle group under conditions of constant muscle blood flow. The animals were not cold acclimatized. Blood flow was pump controlled, alkalosis was produced by hyperventilation, and norepinephrine was infused intravenously at a rate of 1–1.5 μg/kg per minute. Alkalosis had no effect either alone or in combination with changes in blood flow. Similarly, changing blood flow from a low (0.10 ± 0.02 mL/g muscle per minute (mean ± SE)) to a high (0.34 ± 0.04 mL/g muscle per minute) rate did not alter resting oxygen uptake. Norepinephrine caused an average increase of about 30% in resting muscle oxygen uptake which was sustained for the 15-min sampling period during low flow - norepinephrine infusion and during the low and high blood flow - norepinephrine - alkalosis sampling periods. Norepinephrine infusion during the period of high muscle blood flow without alkalosis resulted in a transient increase followed by a decrease in muscle oxygen uptake. The data demonstrated that infusion of norepinephrine increased skeletal muscle oxygen uptake in "non-cold-acclimatized" dogs at low constant muscle blood flow. Further, without alkalosis, the norepinephrine effect at high flow was transient.

Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition

2011 ◽  
Vol 300 (4) ◽  
pp. H1510-H1517 ◽  
Author(s):  
Heinonen Ilkka ◽  
Saltin Bengt ◽  
Kemppainen Jukka ◽  
Hannu T. Sipilä ◽  
Oikonen Vesa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Oxygen Uptake ◽  
Muscle Blood Flow ◽  
Arterial Infusion ◽  
Skeletal Muscle Blood Flow ◽  
Muscle Oxygen ◽  
Resting Muscle ◽  
Muscle Oxygen Uptake

The aim of the present study was to determine the effect of nitric oxide and prostanoids on microcirculation and oxygen uptake, specifically in the active skeletal muscle by use of positron emission tomography (PET). Healthy males performed three 5-min bouts of light knee-extensor exercise. Skeletal muscle blood flow and oxygen uptake were measured at rest and during the exercise using PET with H2O15 and 15O2 during: 1) control conditions; 2) nitric oxide synthase (NOS) inhibition by arterial infusion of NG-monomethyl-l-arginine (l-NMMA), and 3) combined NOS and cyclooxygenase (COX) inhibition by arterial infusion of l-NMMA and indomethacin. At rest, inhibition of NOS alone and in combination with indomethacin reduced ( P < 0.05) muscle blood flow. NOS inhibition increased ( P < 0.05) limb oxygen extraction fraction (OEF) more than the reduction in muscle blood flow, resulting in an ∼20% increase ( P < 0.05) in resting muscle oxygen consumption. During exercise, muscle blood flow and oxygen uptake were not altered with NOS inhibition, whereas muscle OEF was increased ( P < 0.05). NOS and COX inhibition reduced ( P < 0.05) blood flow in working quadriceps femoris muscle by 13%, whereas muscle OEF and oxygen uptake were enhanced by 51 and 30%, respectively. In conclusion, by specifically measuring blood flow and oxygen uptake by the use of PET instead of whole limb measurements, the present study shows for the first time in humans that inhibition of NO formation enhances resting muscle oxygen uptake and that combined inhibition of NOS and COX during exercise increases muscle oxygen uptake.

Sign in / Sign up

Export Citation Format

Share Document