The aim: To study the regulation of acid-base balance and blood acid – renal excretory function in patients with COPD.
Materials and methods: We examined 82 people, suggests that even during the most severe stages of COPD. Group 1 included 56 patients with COPD, group C. The average
age was 60.54 + 2.04 years old, including 24 men and 32 women. The second group included 16 patients with COPD, group B, whose average age was 55.37 + 3.21 years old,
including 7 men and 9 women. The third group included 10 healthy individuals, with an average age of 34.30 + 2.21 years, including 6 men and 4 women. Respiration function
was evaluated on the basis of the forced expiratory curve recorded on a Spirolab II MIR S / N computer spirograph. The following indicators were evaluated: forced vital capacity
(FVC), forced expiratory volume (FEV1) and FEV1 / FVC ratio.
Results: For all patients with COPD there is a characteristic presence of acidosis (pH in patients with COPD group B – 7,34 ± 0,01, in patients with COPD group C – 7,31 ± 0,07).
For patients with COPD group C there are pronounced respiratory disorders (pCO2 – 48,25 + 1,14 mm Hg, p02 – 28.07 +1.37 mm Hg). For patients with COPD group B characteristic
metabolic disorders (BE--3,71 + 0,57), which increase as the disease progresses. For patients with COPD group C this figure is equal to 7.62 + 0.49. Thus, the analysis of indicators
indicates the presence for all patients of mixed (respiratory and metabolic) acidosis, which increases as the chronic obstructive pulmonary disease progresses.
Conclusions: There is activation of acid – renal excretory function and the inclusion of renal mechanisms in the regulation of acid-base balance.