Critical dynamics of lateral and transversal phase separations in bilayer biomembranes and surfactants

2009 ◽  
Vol 29 (3) ◽  
pp. 319-327 ◽  
Author(s):  
M. Ouarch ◽  
M. Benhamou ◽  
M. Chahid ◽  
H. Kaidi
1988 ◽  
Vol 49 (C8) ◽  
pp. C8-1397-C8-1398 ◽  
Author(s):  
N. Ito ◽  
M. Taiji ◽  
M. Suzuki

2019 ◽  
Vol 200 (2) ◽  
pp. 1237-1251 ◽  
Author(s):  
Yu. A. Zhavoronkov ◽  
M. V. Komarova ◽  
Yu. G. Molotkov ◽  
M. Yu. Nalimov ◽  
J. Honkonent

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2118
Author(s):  
Yusuke Hosoya ◽  
Junko Ohkanda

Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid–liquid phase separations—which critically involve both intermolecular interactions between IDPs and their posttranslational modification—are analyzed to understand the potential of IDPs as new drug targets.


2020 ◽  
Vol 10 (1) ◽  
Author(s):  
István A. Kovács ◽  
Róbert Juhász

AbstractPercolation theory dictates an intuitive picture depicting correlated regions in complex systems as densely connected clusters. While this picture might be adequate at small scales and apart from criticality, we show that highly correlated sites in complex systems can be inherently disconnected. This finding indicates a counter-intuitive organization of dynamical correlations, where functional similarity decouples from physical connectivity. We illustrate the phenomenon on the example of the disordered contact process (DCP) of infection spreading in heterogeneous systems. We apply numerical simulations and an asymptotically exact renormalization group technique (SDRG) in 1, 2 and 3 dimensional systems as well as in two-dimensional lattices with long-ranged interactions. We conclude that the critical dynamics is well captured by mostly one, highly correlated, but spatially disconnected cluster. Our findings indicate that at criticality the relevant, simultaneously infected sites typically do not directly interact with each other. Due to the similarity of the SDRG equations, our results hold also for the critical behavior of the disordered quantum Ising model, leading to quantum correlated, yet spatially disconnected, magnetic domains.


2021 ◽  
Vol 7 (18) ◽  
pp. eabc6266
Author(s):  
Qi Li ◽  
Ningkun Liu ◽  
Qing Liu ◽  
Xingguo Zheng ◽  
Lu Lu ◽  
...  

Eukaryotic cells contain numerous membraneless organelles that are made from liquid droplets of proteins and nucleic acids and that provide spatiotemporal control of various cellular processes. However, the molecular mechanisms underlying the formation and rapid stress-induced alterations of these organelles are relatively uncharacterized. Here, we investigated the roles of DEAD-box helicases in the formation and alteration of membraneless nuclear dicing bodies (D-bodies) in Arabidopsis thaliana. We uncovered that RNA helicase 6 (RH6), RH8, and RH12 are previously unidentified D-body components. These helicases interact with and promote the phase separation of SERRATE, a key component of D-bodies, and drive the formation of D-bodies through liquid-liquid phase separations (LLPSs). The accumulation of these helicases in the nuclei decreases upon Turnip mosaic virus infections, which couples with the decrease of D-bodies. Our results thus reveal the key roles of RH6, RH8, and RH12 in modulating D-body formation via LLPSs.


1973 ◽  
Vol 19 (1) ◽  
pp. 109-112 ◽  
Author(s):  
Mohammed Tajuddin ◽  
Stanley G Elfbaum

Abstract The N,O-dipivalyl methyl esters of triiodothyronine and thyroxine were prepared and gas chromatographed. "Dexsil 300 GC," a heat-stable polycarboranesiloxane, was used as the stationary phase. Separations were good and prompt. As little as 250 pg of triiodothyronine was detectable. Dexsil 300 GC was used satisfactorily in measuring serum triiodothyronine


2016 ◽  
Vol 110 (3) ◽  
pp. 17a
Author(s):  
Katherine N. Liu ◽  
Chen-Min S. Hung ◽  
Michael A. Swift ◽  
Kristen A. Muñoz ◽  
Jose L. Cortez ◽  
...  

2006 ◽  
Vol 73 (1) ◽  
Author(s):  
S. H. Kim ◽  
K. W. Lee ◽  
Cheol Eui Lee ◽  
W. Kang ◽  
K. S. Hong
Keyword(s):  

Sign in / Sign up

Export Citation Format

Share Document