EXPLOITING INSTRUCTION REUSE TO IMPROVE THE PERFORMANCE OF DUAL INSTRUCTION EXECUTION

2011 ◽  
Vol 20 (05) ◽  
pp. 899-913
Author(s):  
ABHISHEK PILLAI ◽  
WEI ZHANG

Dual instruction execution (DIE) is an effective instruction-level temporal redundancy technique to improve the datapath reliability against transient errors for superscalar microprocessors. However, previous study shows that the performance overhead of dual instruction execution on an out-of-order core is substantial, primarily due to the serious resource contention problems such as the ALU bandwidth. In this paper, we propose a novel approach to reducing the performance overhead of DIE without compromising the datapath reliability. In the proposed scheme, both the primary and the duplicate instructions of DIE can exploit the ECC-protected instruction reuse buffer (IRB) for mitigating the resource contention of DIE by minimizing the number of dynamic instructions executed, leading to better performance without impacting the reliability of DIE. Our experiments indicate that the proposed approach can reduce the performance loss of dual instruction execution by up to 70.8%, with 51.1% on average, and can reduce the performance loss of DIE–IRB by up to 17.2%, with 7.1% on average, while providing reliability comparable to DIE or DIE–IRB.

2014 ◽  
Vol 635-637 ◽  
pp. 1072-1075
Author(s):  
Xiang Zhi Lu ◽  
Hong Jun Dai ◽  
Lei Ju

Diminutive devices of present and future microprocessor generations are drawing increased attentions for transient errors. To address reliability issues, fault tolerance mechanisms must be taken into consideration. In this paper, we involve Reliability Station (RS) into modern superscalar out-of-order data path. In our proposed mechanism, each instruction in the pipeline will be executed twice and the dual results are stored in RS before they can be used. The fault detection is completed by a comparison between the two results and the recovery is achieved by re-executed the corresponding instructions. The simulation results of 12 benchmarks chosen from spec2000 and mibench show that the performance loss of our solution ranges from 30.29% to 83.32% with an average of 54.90% compared to single instruction execution, which is lower than that of Double Instruction Execution (DIE) schemes with an average of 78.42%. Meanwhile, due to the high efficiency of the recovery, our mechanism will exhibit better performance and power efficiency than DIEs within high transient error rates.


Author(s):  
Susmita J A Nair ◽  
T R Gopalakrishnan Nair

<p class="CAbstract"><span>The performance of servers at the data centers is affected when the servers are overloaded. To overcome this problem, the workload at the overloaded servers has to be redistributed to other servers which is possible with live VM migration. Live migration plays a crucial role in handling the overload at the data centers without service interruption. However, live migration also incurs some performance loss and energy overhead. The energy consumption at the data centers is a matter of utmost concern both in terms of economy and ecology. In this paper we are proposing a novel approach to find the most suitable server for VM placement. We have introduced an Optimal VM Allocation Framework (OVAF) in which the hosts at the source requests the destination for their available slots. Based on the response from the available servers, the utilization factor is calculated and the selection of appropriate destination for VM placement is done. Simulations carried out have shown 10% improvement in energy saving.</span></p>


2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.


2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687


2008 ◽  
Vol 17 (3) ◽  
pp. 87-92
Author(s):  
Leonard L. LaPointe

Abstract Loss of implicit linguistic competence assumes a loss of linguistic rules, necessary linguistic computations, or representations. In aphasia, the inherent neurological damage is frequently assumed by some to be a loss of implicit linguistic competence that has damaged or wiped out neural centers or pathways that are necessary for maintenance of the language rules and representations needed to communicate. Not everyone agrees with this view of language use in aphasia. The measurement of implicit language competence, although apparently necessary and satisfying for theoretic linguistics, is complexly interwoven with performance factors. Transience, stimulability, and variability in aphasia language use provide evidence for an access deficit model that supports performance loss. Advances in understanding linguistic competence and performance may be informed by careful study of bilingual language acquisition and loss, the language of savants, the language of feral children, and advances in neuroimaging. Social models of aphasia treatment, coupled with an access deficit view of aphasia, can salve our restless minds and allow pursuit of maximum interactive communication goals even without a comfortable explanation of implicit linguistic competence in aphasia.


2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
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