Modelling optimal control of African trypanosomiasis disease with cost-effective strategies

2021 ◽  
Author(s):  
Yustina A. Liana ◽  
Nyimvua Shaban ◽  
Goodluck Mlay
Keyword(s):  
Optimal Control ◽  
Cost Effective ◽  
African Trypanosomiasis ◽  
Effective Strategies

scholarly journals Modelling and optimal control of pneumonia disease with cost-effective strategies

2017 ◽  
Vol 11 (sup2) ◽  
pp. 400-426 ◽  
Author(s):  
Getachew Teshome Tilahun ◽  
Oluwole Daniel Makinde ◽  
David Malonza
Keyword(s):  
Optimal Control ◽  
Cost Effective ◽  
Effective Strategies

scholarly journals Optimal Control of Shigellosis with Cost-Effective Strategies

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Stephen Edward ◽  
Nyimvua Shaban ◽  
Eunice Mureithi
Keyword(s):  
Optimal Control ◽  
Cost Effectiveness ◽  
Optimal Control Theory ◽  
Cost Effective ◽  
Incremental Cost Effectiveness Ratio ◽  
Cost Effectiveness Ratio ◽  
Effective Strategies ◽  
Education Campaign ◽  
Effectiveness Analysis ◽  
The Cost

In this paper, we apply optimal control theory to the model for shigellosis. It is assumed that education campaign, sanitation, and treatment are the main controls for this disease. The aim is to minimize the number of infections resulting from contact with careers, infectious population, and contaminated environments while keeping the cost of associated controls minimum. We achieve this aim through the application of Pontryagin’s Maximum Principle. Numerical simulations are carried out by using both forward and backward in time fourth-order Runge-Kutta schemes. We simulate the model under different strategies to investigate which option could yield the best results. The findings show that the strategy combining all three control efforts (treatment, sanitation, and education campaign) proves to be more beneficial in containing shigellosis than the rest. On the other hand, cost-effectiveness analysis is performed via incremental cost-effectiveness ratio (ICER). The findings from the ICER show that a strategy incorporating all three controls (treatment, sanitation, and education campaign) is the most cost-effective of all strategies considered in the study.

scholarly journals Modelling and Optimal Control of Typhoid Fever Disease with Cost-Effective Strategies

2017 ◽  
Vol 2017 ◽  
pp. 1-16 ◽  
Author(s):  
Getachew Teshome Tilahun ◽  
Oluwole Daniel Makinde ◽  
David Malonza
Keyword(s):  
Optimal Control ◽  
Typhoid Fever ◽  
Control Strategies ◽  
Cost Effective ◽  
Basic Reproductive Number ◽  
Reproductive Number ◽  
Effective Strategies ◽  
Next Generation Matrix ◽  
The Cost ◽  
Disease Free

We propose and analyze a compartmental nonlinear deterministic mathematical model for the typhoid fever outbreak and optimal control strategies in a community with varying population. The model is studied qualitatively using stability theory of differential equations and the basic reproductive number that represents the epidemic indicator is obtained from the largest eigenvalue of the next-generation matrix. Both local and global asymptotic stability conditions for disease-free and endemic equilibria are determined. The model exhibits a forward transcritical bifurcation and the sensitivity analysis is performed. The optimal control problem is designed by applying Pontryagin maximum principle with three control strategies, namely, the prevention strategy through sanitation, proper hygiene, and vaccination; the treatment strategy through application of appropriate medicine; and the screening of the carriers. The cost functional accounts for the cost involved in prevention, screening, and treatment together with the total number of the infected persons averted. Numerical results for the typhoid outbreak dynamics and its optimal control revealed that a combination of prevention and treatment is the best cost-effective strategy to eradicate the disease.

Bioavailability of phosphorus as a tool for efficient P reduction schemes

1998 ◽  
Vol 37 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Peter Gerdes ◽  
Sabine Kunst
Keyword(s):  
Sewage Treatment ◽  
Cost Effective ◽  
Effective Management ◽  
Lower Saxony ◽  
Effective Strategies ◽  
P Balance ◽  
Different Sources ◽  
Total P ◽  
P Sources ◽  
P Bioavailability

The bioavailability of phosphorus from different sources has been evaluated in the catchment area of the River Ilmenau (Lower-Saxony, Germany) by using algal assays. The P bioavailability describes the different potential of P from various sources of supporting eutrophication. Effluents from sewage treatment plants were highly bioavailable (72% of TP) whereas rainwater (26%) and erosion effluents (30%) showed a low bioavailability. In order to develop effective strategies to minimize P inputs into the river, source specific P bioavailability indices were determined and combined with a P balance to calculate inputs of vioavailable P (BAP) instead of total P (TP). It could be shown that the relative importance of the different P sources changes when applying BAP. Measures to reduce P inputs into the River Ilmenau will take P bioavailability into consideration and therefore lead to a more cost-effective management.

scholarly journals Platforms for Production of Protein-Based Vaccines: From Classical to Next-Generation Strategies

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1072
Author(s):  
Raquel Cid ◽  
Jorge Bolívar
Keyword(s):  
Infectious Diseases ◽  
Mammalian Cells ◽  
Vaccine Development ◽  
Low Cost ◽  
Cost Effective ◽  
Insect Larvae ◽  
Subunit Vaccines ◽  
Effective Strategies ◽  
Alternative Systems ◽  
Inactivated Vaccines

To date, vaccination has become one of the most effective strategies to control and reduce infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were developed as live-attenuated or inactivated pathogens, and, although they still represent the most extended human vaccine types, they also face some issues, such as the potential to revert to a pathogenic form of live-attenuated formulations or the weaker immune response associated with inactivated vaccines. Advances in genetic engineering have enabled improvements in vaccine design and strategies, such as recombinant subunit vaccines, have emerged, expanding the number of diseases that can be prevented. Moreover, antigen display systems such as VLPs or those designed by nanotechnology have improved the efficacy of subunit vaccines. Platforms for the production of recombinant vaccines have also evolved from the first hosts, Escherichia coli and Saccharomyces cerevisiae, to insect or mammalian cells. Traditional bacterial and yeast systems have been improved by engineering and new systems based on plants or insect larvae have emerged as alternative, low-cost platforms. Vaccine development is still time-consuming and costly, and alternative systems that can offer cost-effective and faster processes are demanding to address infectious diseases that still do not have a treatment and to face possible future pandemics.

scholarly journals Innovating on Inhaled Bioequivalence: A Critical Analysis of the Current Limitations, Potential Solutions and Stakeholders of the Process

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1051
Author(s):  
Jonattan Gallegos-Catalán ◽  
Zachary Warnken ◽  
Tania F. Bahamondez-Canas ◽  
Daniel Moraga-Espinoza
Keyword(s):  
New Technologies ◽  
Innovation Process ◽  
Cost Effective ◽  
Regulatory Agencies ◽  
Drug Products ◽  
Effective Strategies ◽  
Rate Analysis ◽  
Orally Inhaled Drug Products ◽  
Next Generation Impactor ◽  
First Time

Orally inhaled drug products (OIDPs) are an important group of medicines traditionally used to treat pulmonary diseases. Over the past decade, this trend has broadened, increasing their use in other conditions such as diabetes, expanding the interest in this administration route. Thus, the bioequivalence of OIDPs is more important than ever, aiming to increase access to affordable, safe and effective medicines, which translates into better public health policies. However, regulatory agencies leading the bioequivalence process are still deciding the best approach for ensuring a proposed inhalable product is bioequivalent. This lack of agreement translates into less cost-effective strategies to determine bioequivalence, discouraging innovation in this field. The Next-Generation Impactor (NGI) is an example of the slow pace at which the inhalation field evolves. The NGI was officially implemented in 2003, being the last equipment innovation for OIDP characterization. Even though it was a breakthrough in the field, it did not solve other deficiencies of the BE process such as dissolution rate analysis on physiologically relevant conditions, being the last attempt of transferring technology into the field. This review aims to reveal the steps required for innovation in the regulations defining the bioequivalence of OIDPs, elucidating the pitfalls of implementing new technologies in the current standards. To do so, we collected the opinion of experts from the literature to explain these trends, showing, for the first time, the stakeholders of the OIDP market. This review analyzes the stakeholders involved in the development, improvement and implementation of methodologies that can help assess bioequivalence between OIDPs. Additionally, it presents a list of methods potentially useful to overcome some of the current limitations of the bioequivalence standard methodologies. Finally, we review one of the most revolutionary approaches, the inhaled Biopharmaceutical Classification System (IBCs), which can help establish priorities and order in both the innovation process and in regulations for OIDPs.

scholarly journals Challenges for Evaluation of the Safety of Engineered Nanomaterials

2021 ◽  
Vol 43 (1) ◽  
pp. 4-7
Author(s):  
Linda J. Johnston ◽  
Norma Gonzalez-Rojano ◽  
Kevin J. Wilkinson ◽  
Baoshan Xing
Keyword(s):  
Rapid Development ◽  
Sustainable Use ◽  
Cost Effective ◽  
Engineered Nanomaterials ◽  
Full Potential ◽  
Effective Strategies ◽  
Toxicological Studies ◽  
Regulatory Guidelines ◽  
Significant Effort ◽  
Safe By Design

Abstract Nanotechnology has developed rapidly in the last two decades with significant effort focused on the development of nano-enabled materials with new or improved properties that offer solutions for current world challenges. The commercialization of products containing engineered nanomaterials (ENM) has progressed much more rapidly than the development of practical approaches to ensure their safe and sustainable use. The lack of adequate detection and characterization techniques and reproducible and validated methods for toxicological studies have been identified as major limitations. The rapid development of ENM of increasing complexity and diversity and concerns over the adequacy of existing regulations also contribute to safety concerns with these materials. The full potential of nanotechnology can only be realized when feasible, cost-effective strategies to ensure a safe-by-design approach, effective risk assessment approaches and appropriate regulatory guidelines are in place.

scholarly journals Cost-effective Strategies for the Management and Treatment of Urethral Stricture Disease

2017 ◽  
Vol 44 (1) ◽  
pp. 11-17 ◽  
Author(s):  
E. Charles Osterberg ◽  
Gregory Murphy ◽  
Catherine R. Harris ◽  
Benjamin N. Breyer
Keyword(s):  
Urethral Stricture ◽  
Cost Effective ◽  
Effective Strategies ◽  
Urethral Stricture Disease

scholarly journals Prevention of Leptospirosis Infected Vector and Human Population by Multiple Control Variables

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Muhammad Altaf Khan ◽  
Saeed Islam ◽  
Sher Afzal Khan ◽  
Ilyas Khan ◽  
Sharidan Shafie ◽  
...  
Keyword(s):  
Optimal Control ◽  
Optimal Control Problem ◽  
Control Problem ◽  
Human Population ◽  
Cost Effective ◽  
Farm Animals ◽  
Effective Control ◽  
Multiple Control ◽  
Control Variables ◽  
Control Functions

Leptospirosis is an infectious disease that damages the liver and kidneys, found mainly in dogs and farm animals and caused by bacteria. In this paper, we present the optimal control problem applied to a dynamical leptospirosis infected vector and human population by using multiple control variables. First, we show the existence of the control problem and then use analytical and numerical techniques to investigate the existence cost effective control efforts for prevention of indirect and direct transmission of this disease. In order to do this, we consider three control functions two for human and one for vector population. We completely characterize the optimal control problem and compute the numerical solution of the optimality system using an iterative method.

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