Crown ether functionalized texaphyrin monomers and dimers
2011 ◽
Vol 15
(07n08)
◽
pp. 539-546
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Keyword(s):
The synthesis and characterization of two 18-crown-6 functionalized analogues of an extensively studied gadolinium texaphyrin derivative, motexafin gadolinium (1, MGd), are reported. These are the monomeric and dimeric species, compounds 2 and 3, respectively. Both crown ether functionalized species proved to be stable at physiological pH and revealed distinct shifts in the UV spectrum when treated with sodium-, potassium-, ammonium- or zinc(II)-salts. Zinc(II) is believed to play a major role regulating apoptosis mechanisms in cancerous cells. Therefore, cytotoxicity studies of 2 and 3 were carried out using the Ramos cell line in the presence and absence of zinc(II).
2017 ◽
Vol V
(XI)
◽
pp. 1093-1098
2017 ◽
Vol 827
◽
pp. 32-40
◽
2007 ◽
Vol 48
(23)
◽
pp. 4091-4095
◽
Keyword(s):
2011 ◽
Vol 8
(4)
◽
pp. 317-320
◽