Fully-Coupled Transient Fluid–Solid Interaction Simulation of the pH-Sensitive Hydrogel-Based Microvalve

2019 ◽  
Vol 11 (07) ◽  
pp. 1950071 ◽  
Author(s):  
Mohammad Reza Bayat ◽  
Mostafa Baghani

The pH-sensitive hydrogels are attractive candidates to act like a microvalve in microfluidic devices. In this study, we build a theory for the transient simulation of a pH-sensitive hydrogel-based microvalve. Three fields are involved in the theory, namely the electrochemical, mechanical and fluid fields. We utilize the Nernst–Planck equation to describe the ionic flux into the hydrogel through diffusion, electrical migration and convection. We model the hydrogel as a compressible isotropic hyperelastic material with the Gent model. Then we implement the theory in a nonlinear finite element framework to simulate the time-dependent fluid–solid interaction (FSI) behavior of the pH-sensitive microvalve. Our focus is on exploring the physics and phenomena involving in the simulation rather than simulating a complex geometry or presenting a new design. We manifest the significance of the FSI by comparing the transient FSI and non-FSI simulation of the microvalve. The most highlighted novelty of our study is accounting for time-dependent effects. The results demonstrate that the microvalve perfectly closes the channel much before it reaches its stationary state and the closing state, which is of high interest in the microvalve study is different from the stationary state.

Author(s):  
Soha Niroumandi ◽  
Mohammad Shojaeifard ◽  
Mostafa Baghani

pH-sensitive hydrogels are promising materials to be employed in microfluidic devices, especially microvalves. In this paper, a theory of transient swelling of pH-sensitive micro-valve is presented. A transient constitutive model that captures electrical, chemical, and mechanical fields is considered to model the swelling phenomenon. The diffusion of ions into the hydrogel, the electromigration, and convection are described by implementing the Nernst-Planck equation. Assuming Gent model, hydrogel is considered as a compressible hyperelastic material and osmotic pressure is assumed as an external loading. Due to benefits of in-plane valves, a design of the micro-valve is studied. Design simplicity and great sealing are vital factors which can be considered as an advantage of this valve for fabrication. This design and modeling approach has not been used for pH-sensitive hydrogels in earlier works. Thus, we have studied the transient swelling of pH-sensitive hydrogel microvalve, when effects of fluid-structure-interaction are examined on valve performance. It is noted that in most previous studies, equilibrium conditions have been assumed. While considering transient fully-coupled fluid-structure-interaction is necessary to capture a more realistic modeling. The results illustrate that the microvalve blocks the channel much earlier than reaching the equilibrium-state, which implies importance of the transient behavior of hydrogels.


2005 ◽  
Vol 227 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Anish P. Dhanarajan ◽  
Ronald A. Siegel

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Pooja Sharma ◽  
Anuj Chawla ◽  
Pravin Pawar

The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture and further coated with Eudragit S-100 by dip immerse method. Thein vitrodrug release study was conducted in different dissolution media such as pH 1.2, 6.8, and 7.4 with or without rat caecal content to simulate GIT conditions. Surface morphology and cross-sectional view of the tablets were visualized by scanning electron microscopy (SEM). All prepared batches were in compliance with the pharmacopoeial standards. The tablets which are compression coated with HPC followed by Eudragit S-100 coated showed highestin vitrodrug release of 98.10% in presence of rat caecal content. The SEM of tablets suggested that the number of pores got increased in pH 7.4 medium followed by dissolution of coating layer. The tablets coat erosion study suggested that the lag time depends upon the coating concentrations of polymers. A time-dependent hydrophilic polymer and pH sensitive polymer based press-coated tablets of naproxen were promising delivery for colon targeting.


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