Computer simulation on polymer micelles combined administration of gambogic acid and curcumin as a novel anti-cancer drug carrier

NANO ◽  
2021 ◽  
Author(s):  
Jinglei Wang ◽  
Mingrui Guo ◽  
Feifei Lu ◽  
Hao Pan ◽  
Mingxia Liu ◽  
...  
Keyword(s):  
Computer Simulation ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Gambogic Acid ◽  
Polymer Micelles ◽  
Anti Cancer ◽  
Combined Administration

Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier

2018 ◽  
Vol 18 (2) ◽  
pp. 302-311
Author(s):  
Shulin Dai ◽  
Yucheng Feng ◽  
Shuyi Li ◽  
Yuxiao Chen ◽  
Meiqing Liu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Anti Cancer ◽  
Physical Interactions

Background: Micelles as drug carriers are characterized by their inherent instability due to the weak physical interactions that facilitate the self-assembly of amphiphilic block copolymers. As one of the strong physical interactions, the stereocomplexation between the equal molar of enantiomeric polylactides, i.e., the poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), may be harnessed to obtain micelles with enhanced stability and drug loading capacity and consequent sustained release. </P><P> Aims/Methods: In this paper, stereocomplexed micelles gama-PGA-g-PLA micelles) were fabricated from the stereocomplexation between poly(gama-glutamic acid)-graft-PLLA gama-PGA-g-PLA) and poly(gamaglutamic acid)-graft-PDLA gama-PGA-g-PLA). These stereocomplexed micelles exhibited a lower CMC than the corresponding enantiomeric micelles. Result: Furthermore, they showed higher drug loading content and drug loading efficiency in addition to more sustained drug release profile in vitro. In vivo imaging confirmed that the DiR-encapsulated stereocomplexed gama-PGA-g-PLA micelles can deliver anti-cancer drug to tumors with enhanced tissue penetration. Overall, gama-PGA-g-PLA micelles exhibited greater anti-cancer effects as compared with the free drug and the stereocomplexation may be a promising strategy for fabrication of anti-cancer drug carriers with significantly enhanced efficacy.

Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriers

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 38810-38817 ◽  
Author(s):  
Yeping Li ◽  
Jingbo Xu ◽  
Yun Xu ◽  
Liying Huang ◽  
Junli Wang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Synthesis And Characterization ◽  
Potential Drug ◽  
Zns Nanoparticles ◽  
New Approach ◽  
Anti Cancer

The objective of the study is to describe a new approach of combining quantum dots into chitosan as an anti-cancer drug carrier.

Chondroitin sulfate-curcumin micelle with good stability and reduction sensitivity for anti-cancer drug carrier

2021 ◽  
pp. 130667
Author(s):  
Shao-Fei Zhang ◽  
Wenbin Hu ◽  
Xiang Yan ◽  
Duliu Wang ◽  
Wen Yang ◽  
...  
Keyword(s):  
Chondroitin Sulfate ◽  
Drug Carrier ◽  
Good Stability ◽  
Cancer Drug ◽  
Anti Cancer

Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier

2008 ◽  
Vol 35 (4) ◽  
pp. 271-282 ◽  
Author(s):  
Zheyu Shen ◽  
Wei Wei ◽  
Yongjiang Zhao ◽  
Guanghui Ma ◽  
Toshiaki Dobashi ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Cancer Drug ◽  
Thermosensitive Polymer ◽  
Anti Cancer ◽  
Thermal Targeting

Synthesis of Polynucleotide Modified Gold Nanoparticles as a High Potent Anti-Cancer Drug Carrier

2009 ◽  
Vol 56 (4) ◽  
pp. 703-708 ◽  
Author(s):  
Ching-Ming Wu ◽  
Ping-Ching Wu ◽  
Yun-Han Wang ◽  
Tsung-Ju Li ◽  
Li-Xing Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Anti Cancer

scholarly journals Hydrophilic Polyhedral Oligomeric Silsesquioxane, POSS(OH)32, as a Complexing Nanocarrier for Doxorubicin and Daunorubicin

Materials ◽  
2020 ◽  
Vol 13 (23) ◽  
pp. 5512 ◽  
Author(s):  
Kinga Piorecka ◽  
Anna Janaszewska ◽  
Marta Majkowska ◽  
Monika Marcinkowska ◽  
Jan Kurjata ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Correlation Spectroscopy ◽  
Hydroxyl Group ◽  
Cancer Drug ◽  
Breast Adenocarcinoma ◽  
Hydroxyl Groups ◽  
Polyhedral Oligomeric Silsesquioxanes ◽  
Molar Ratios ◽  
Anti Cancer ◽  
Mcf 7

A novel strategy, recently developed by us, to use polyhedral oligomeric silsesquioxanes (POSS) as an anti-cancer drug carrier is presented. Anthracycline:POSS complexes were prepared by simple co-addition of doxorubicin (DOX) or daunorubicin (DAU) with hydrophilic POSS(OH)32. Co-delivery of POSS and anthracyclines led to higher anti-cancer activity towards HeLa (cervical cancer endothelial) and MCF-7 (human breast adenocarcinoma) cell lines. The obtained supramolecular hybrid complexes were characterised by nuclear magnetic resonance (NMR) spectroscopy (nuclear Overhauser effect spectroscopy [NOESY] and homonuclear correlation spectroscopy [COSY]), Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS). The two-dimensional (2D) NOESY spectra of the complexes showed the cross-correlation peaks for hydroxyl groups of POSS (~4.3–4.8 ppm) with OH groups of DOX and DAU. FTIR showed that hydroxyl group of POSS can interact with amine and hydroxyl groups of DOX and DAU. The viability of HeLa and MCF-7 was analysed with the MTT assay to evaluate the cytotoxicity of free DOX and DAU and the relevant complexes with POSS at different molar ratios. At a low DOX concentration (2.5 µM), for molar ratios 1:1, 1:4, and 1:8 (POSS:DOX), the complexes showed two and three times higher cytotoxicity towards HeLa and MCF-7 cells, respectively, than DOX itself after both 24- and 48-h incubation. The 1 µM concentration for a 1:4 POSS:DOX molecular ratio and the 2.5 µM concentration for all complexes were more toxic towards MCF-7 cells than free DOX after 48-h incubation. In the case of POSS:DAU complexes, there was higher toxicity than that of free drug after 48-h incubation. It can be concluded that the formation of non-covalent complexes increases toxicity of anthracycline drugs towards Hela and MCF-7 cells. The novel complexes are inexpensive to prepare and more effective than free drugs at low systemic toxicity.

Si-doped phagraphene as a drug carrier for adrucil anti-cancer drug: DFT studies

2018 ◽  
Vol 90 ◽  
pp. 8-14 ◽  
Author(s):  
Rayehe Bagheri ◽  
Mirzaagha Babazadeh ◽  
Esmail Vessally ◽  
Moosa Es'haghi ◽  
Ahmadreza Bekhradnia
Keyword(s):  
Drug Carrier ◽  
Cancer Drug ◽  
Dft Studies ◽  
Anti Cancer ◽  
Si Doped

A New Fluorometric Method for the Determination of Oxaliplatin Based on Cucurbit[7]uril Supramolecular Interaction

2017 ◽  
Vol 70 (6) ◽  
pp. 677 ◽  
Author(s):  
YinXia Chang ◽  
XueChao Duan ◽  
XiangMei Zhang ◽  
Fan Liu ◽  
LiMing Du
Keyword(s):  
Fluorescence Intensity ◽  
Drug Carrier ◽  
Cancer Drug ◽  
Supramolecular Interaction ◽  
Competitive Reaction ◽  
Fluorometric Method ◽  
Normal Tissues ◽  
Anti Cancer ◽  
Reduced Toxicity

This paper proposed new competitive methods for fluorescence detection of the anti-cancer drug oxaliplatin. The methods were based on the competitive reaction of palmatine (PAL)/berberine (BER)/coptisine (COP) with oxaliplatin for the occupancy of cucurbit[7]uril (CB[7]) cavities. The results showed that the fluorescence intensity of PAL, BER, and COP regularly increased upon addition of CB[7] until a certain amount of oxaliplatin was added, at which stage the fluorescence intensity of the system quenched. Using the CB[7]–PAL, CB[7]–BER, and CB[7]–COP systems, linear ranges in the detection of oxaliplatin of 0.005–1.75, 0.010–1.50, and 0.020–1.05 μg mL–1, with detection limits of 2, 3, and 7 ng mL–1, respectively, were obtained. These results suggest that cucurbit[7]uril is a promising drug carrier for delivering and monitoring targeted oxaliplatin, with improved anti-tumour efficacy and reduced toxicity in normal tissues.

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