scholarly journals Iron Oxide Nanoparticles for Magnetic Hyperthermia

SPIN ◽  
2019 ◽  
Vol 09 (02) ◽  
pp. 1940001 ◽  
Author(s):  
N. A. Usov
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Stochastic Equation ◽  
Sharp Decrease ◽  
Dipole Interaction ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles

Assemblies of magnetic nanoparticles show a great potential for application in biomedicine, particularly, magnetic hyperthermia. However, to achieve desired therapeutic effect in magnetic hyperthermia, the assembly of nanoparticles should have a sufficiently high specific absorption rate (SAR) in alternating magnetic field of moderate amplitude and frequency. Using the Landau–Lifshitz stochastic equation, it is shown that dilute assemblies of iron oxide nanoparticles of optimal diameters are capable of providing SAR of the order of 400–600[Formula: see text]W/g in alternating magnetic field with the amplitude [Formula: see text][Formula: see text]Oe in the frequency range f = 300–500[Formula: see text]kHz. Unfortunately, in dense clusters of magnetic nanoparticles, which are often formed in a biological medium, there is a sharp decrease in SAR due to the influence of strong magneto-dipole interaction of closest nanoparticles. To overcome this difficulty, it is suggested covering the nanoparticles with nonmagnetic shells of sufficient thickness or using non-single-domain nanoparticles being in magnetization curling states.

AMF-responsive doxorubicin loaded β-cyclodextrin-decorated superparamagnetic nanoparticles

2018 ◽  
Vol 42 (1) ◽  
pp. 671-680 ◽  
Author(s):  
Evelyn C. da S. Santos ◽  
Amanda Watanabe ◽  
Maria D. Vargas ◽  
Marcelo N. Tanaka ◽  
Flavio Garcia ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Controlled Release ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Nanoparticles ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles ◽  
Release System ◽  
Controlled Release System

An alternating magnetic field (AMF)-responsive controlled release system has been developed by the binding of mono-6-deoxy-6-(p-tolylsulfonyl)-β-cyclodextrin (βCD-Ts) onto amine-modified superparamagnetic iron oxide nanoparticles (MNP-NH2), resulting in a MNP-βCD nanocarrier.

scholarly journals Non-Temperature Induced Effects of Magnetized Iron Oxide Nanoparticles in Alternating Magnetic Field in Cancer Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156294 ◽  
Author(s):  
Sudath Hapuarachchige ◽  
Yoshinori Kato ◽  
Ethel J. Ngen ◽  
Barbara Smith ◽  
Michael Delannoy ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles

scholarly journals Examining the effect of ions and proteins on the heat dissipation of iron oxide nanocrystals

RSC Advances ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 1443-1450
Author(s):  
V. Kalidasan ◽  
X. L. Liu ◽  
Y. Li ◽  
P. J. Sugumaran ◽  
A. H. Liu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Heat Dissipation ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles

In this paper, the effect and contribution of physiological components like ions and proteins under an applied alternating magnetic field (AMF) towards heat dissipation of superparamagnetic iron oxide nanoparticles (SPIONs) are discussed.

scholarly journals In Vivo Imaging of Local Gene Expression Induced by Magnetic Hyperthermia

2017 ◽  
Author(s):  
Olivier Sandre ◽  
Coralie Genevois ◽  
Eneko Garaio ◽  
Laurent Adumeau ◽  
Stéphane Mornet ◽  
...  
Keyword(s):  
Gene Expression ◽  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Non Invasive ◽  
Nanoparticles Dispersions

The present work aims to demonstrate that colloidal dispersions of magnetic iron oxide nanoparticles stabilized with dextran macromolecules placed in an alternating magnetic field can not only produce heat, but also that these particles could be used in vivo for local and non-invasive deposition of a thermal dose sufficient to trigger thermo-induced gene expression. Iron oxide nanoparticles were first characterized in vitro on a bio-inspired setup, and then they were assayed in vivo using a transgenic mouse strain expressing the luciferase reporter gene under transcriptional control of a thermosensitive promoter. Iron oxide nanoparticles dispersions were applied topically on the mouse skin or injected sub-cutaneously with Matrigel™ to generate so called pseudo tumors. Temperature was monitored continuously with a feedback loop to control the power of the magnetic field generator and to avoid overheating. Thermo-induced luciferase expression was followed by bioluminescence imaging 6 hours after heating. We showed that dextran-coated magnetic iron oxide nanoparticles dispersions were able to induce in vivo mild hyperthermia compatible with thermo-induced gene expression in surrounding tissues and without impairing cell viability. These data open new therapeutic perspectives for using mild magnetic hyperthermia as non-invasive modulation of tumor microenvironment by local thermo-induced gene expression or drug release.

scholarly journals Accelerated generation of free radicals by iron oxide nanoparticles in the presence of an alternating magnetic field

RSC Advances ◽  
2015 ◽  
Vol 5 (24) ◽  
pp. 18888-18893 ◽  
Author(s):  
Robert J. Wydra ◽  
Catherine E. Oliver ◽  
Kimberly W. Anderson ◽  
Thomas D. Dziubla ◽  
J. Zach Hilt
Keyword(s):  
Magnetic Field ◽  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles ◽  
Oxygen Species

The catalytic generation of reactive oxygen species from the surface of iron oxide nanoparticles is enhanced through the activated heating with exposure to an alternating magnetic field.

scholarly journals Electrostatically modulated magnetophoretic transport of functionalised iron-oxide nanoparticles through hydrated networks

Nanoscale ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 10550-10558 ◽  
Author(s):  
Stephen Lyons ◽  
Eoin P. Mc Kiernan ◽  
Garret Dee ◽  
Dermot F. Brougham ◽  
Aoife Morrin
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Field Gradient ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Field Gradient ◽  
Polymer Networks ◽  
Oxide Nanoparticles

Factors that determine magnetophoretic transport of magnetic nanoparticles (MNPs) through hydrated polymer networks under the influence of an external magnetic field gradient were studied.

Exploiting shape-selected iron oxide nanoparticles for the destruction of robust bacterial biofilms – active transport of biocides via surface charge and magnetic field control

Nanoscale ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 4328-4333
Author(s):  
Rachel Nickel ◽  
Mohammad Reza Kazemian ◽  
Yaroslav Wroczynskyj ◽  
Song Liu ◽  
Johan van Lierop
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Surface Charge ◽  
Iron Oxide Nanoparticles ◽  
Active Transport ◽  
Bacterial Biofilms ◽  
Oxide Nanoparticles ◽  
Field Control

Biocide-loaded magnetic nanoparticles actively transport biocides through bacterial biofilms, with biocide loading and particle efficacy improved for non-spherical shapes such as cubes and tetrapods.

scholarly journals Effect of Alternating Magnetic Field on the Growth of Different Strains of Bacteria in the Presence of Iron Oxide Nanoparticles

2018 ◽  
Vol 134 (1) ◽  
pp. 133-134
Author(s):  
M-Ali H. Al-Akhras ◽  
B. Albiss ◽  
M.K. Qaseer ◽  
R. Alkhatib ◽  
M.A. Al-Ghbari ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles ◽  
Different Strains
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