Diagnosis and Treatment of Tumors of the Head and Neck (Not Including the Central Nervous System)Diagnosis and Treatment of Tumors of the Head and Neck (Not Including the Central Nervous System). By WardGrant E., M.D., D.Sc, F.A.C.S., HendrickJames W., M.D., M.S., and BlalockAlfred, M.D. From the Departments of Surgery of the School of Medicine, University of Maryland, and the Johns Hopkins University School of Medicine, and the Oncology Clinic of the University Hospital and the Tumor Clinic of the Johns Hopkins Hospital. A volume of 832 pages, with 637 figures and 9 color plates. Published by Williams & Wilkins Co., Baltimore, Md., 1950. Price $15.00.

The favorable results obtained by other authors with polichemotherapy encouraged us to employ therapeutic scheme using a combination of 4 drugs. Treatment envolved the administration of 300 mg/m2 cyclophosphamide, 350 mg/m2 5-fluorouracil, 10 mg/m2 methotrexate i.v. on alternate days 6–8 times, and 15 mg bleomycin on alternate days until a total dose of 150–200 mg is reached. Thirty-five out of 37 patients treated with this protocol (30 previously treated and 5 not) qualified for analysis; the site of the neoplasm, mostly squamous cell carcinoma, was different; for the most part it was in the larynx (18/35) and the oral cavity (10/35). Complete remission was achieved in 9/35 patients (25.7%), varying from 5 to 33 months (median 22); partial remission was achieved in 15/35 cases (42.8%), varying from 1 to 14 months (median 3); and there was no success in 11/35 cases (31.5%). Overall, a total remission > 50 % was observed in 24/35 patients (68.5 %). The most serious side effects both ascribed to BLM were observed in the central nervous system (increasing drowsiness and coma) and the lung. This study has shown that in the ultra head and neck malignancies medical treatment can achieve satisfactory results.

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The Diagnosis and Treatment of Trauma to the Central Nervous System

Medical Clinics of North America ◽

10.1016/s0025-7125(16)34512-6 ◽

1956 ◽

Vol 40 (5) ◽

pp. 1369-1384

Author(s):

Richard C. Schneider

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Diagnosis And Treatment ◽

The Central Nervous System

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Radiation-associated Tumors in the Central Nervous System and the Head and Neck: What Radiologists Should Know

Neurographics ◽

10.3174/ng.2160148 ◽

2016 ◽

Vol 6 (2) ◽

pp. 88-97 ◽

Cited By ~ 1

Author(s):

A. Sakata ◽

M. Kanagaki ◽

T. Okada ◽

A. Yamamoto ◽

Y. Fushimi ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Head And Neck ◽

The Central Nervous System ◽

Associated Tumors

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Hunterian Lecture ON THE DIAGNOSIS AND TREATMENT OF SYPHILIS OF THE CENTRAL NERVOUS SYSTEM: WITH SPECIAL REFERENCE TO THE USE OF NOVARSENOBILLON

The Lancet ◽

10.1016/s0140-6736(01)23959-2 ◽

1918 ◽

Vol 191 (4929) ◽

pp. 243-250

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Special Reference ◽

Diagnosis And Treatment ◽

The Central Nervous System

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THE NERVOUS SYSTEM DAMAGE IN COVID-19 PATIENTS

Clinical Practice ◽

10.17816/clinpract34851 ◽

2020 ◽

Author(s):

Vladimir V. Belopasov ◽

Ekaterina M. Samoilova ◽

Vladimir P. Baklaushev

Keyword(s):

Central Nervous System ◽

Nervous System ◽

International Cooperation ◽

Clinical Manifestations ◽

Interdisciplinary Approach ◽

Radiological Diagnosis ◽

Diagnosis And Treatment ◽

New Methods ◽

The Central Nervous System ◽

Course Outcomes

Based on the available publications, the article systematizes the forms of damage to the central nervous system in СOVID-19patients. Along with a description of clinical manifestations, pathogenesis, methods of laboratory, instrumental and radiological diagnosis with the discussion of the nosological forms. An interdisciplinary approach and international cooperation are required to study the problems pathogenesis, course, outcomes, and the development of new methods of diagnosis and treatment.

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Intraoperative Consultation, Cytologic Preparations, and Frozen Section in the Central Nervous System

Archives of Pathology & Laboratory Medicine ◽

10.5858/2005-129-1635-iccpaf ◽

2005 ◽

Vol 129 (12) ◽

pp. 1635-1652 ◽

Cited By ~ 9

Author(s):

Suzanne Z. Powell

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Frozen Section ◽

Error Rates ◽

Diagnosis And Treatment ◽

Frozen Sections ◽

Simplified Approach ◽

Intraoperative Management ◽

The Central Nervous System ◽

Careful Assessment

Abstract Context.—Intraoperative evaluation of lesions in the central nervous system requires the correlation of clinical, radiologic, and histologic data and knowledge of clinicopathologic entities and their common locations. Advances in neuroimaging during the last 20 years have revolutionized the diagnosis and treatment of central nervous system diseases. The diagnosis and treatment of patients have improved because of these changes and have allowed access to regions that were previously inaccessible. These new approaches have placed the pathologist in a key role in the diagnosis and treatment of patients with central nervous system lesions. Assessment of the adequacy of the material, particularly for stereotactic biopsies, is necessary, and a combination of cytologic imprint preparations and frozen sections are often used. This review discusses many of the issues involved in intraoperative consultation and provides a simplified approach to the differential diagnosis of a variety of central nervous system lesions that may be encountered intraoperatively. Objective.—To provide guidelines for and address potential pitfalls in the intraoperative management of the central nervous system. Data Sources.—Author's experience and pertinent literature. Conclusions.—Careful assessment of the gross specimen coupled with prudent use of frozen sections and cytologic imprint preparations is pivotal to reducing intraoperative error rates and preventing needless anxiety for the patient.

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