Radiation-associated Tumors in the Central Nervous System and the Head and Neck: What Radiologists Should Know

Neurographics ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 88-97 ◽  
Author(s):  
A. Sakata ◽  
M. Kanagaki ◽  
T. Okada ◽  
A. Yamamoto ◽  
Y. Fushimi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Head And Neck ◽  
The Central Nervous System ◽  
Associated Tumors

Polichemotherapy of Advanced Head and Neck Malignancies

1976 ◽  
Vol 62 (6) ◽  
pp. 599-607 ◽  
Author(s):  
Massimo Fazio ◽  
Pietro Cavallero ◽  
Ezio Minetto ◽  
Pier Giorgio Rattalino ◽  
Silvio Sartoris
Keyword(s):  
Central Nervous System ◽  
Squamous Cell Carcinoma ◽  
Nervous System ◽  
Side Effects ◽  
Head And Neck ◽  
Advanced Head ◽  
Head And Neck Malignancies ◽  
The Central Nervous System ◽  
Previously Treated ◽  
Total Remission

The favorable results obtained by other authors with polichemotherapy encouraged us to employ therapeutic scheme using a combination of 4 drugs. Treatment envolved the administration of 300 mg/m2 cyclophosphamide, 350 mg/m2 5-fluorouracil, 10 mg/m2 methotrexate i.v. on alternate days 6–8 times, and 15 mg bleomycin on alternate days until a total dose of 150–200 mg is reached. Thirty-five out of 37 patients treated with this protocol (30 previously treated and 5 not) qualified for analysis; the site of the neoplasm, mostly squamous cell carcinoma, was different; for the most part it was in the larynx (18/35) and the oral cavity (10/35). Complete remission was achieved in 9/35 patients (25.7%), varying from 5 to 33 months (median 22); partial remission was achieved in 15/35 cases (42.8%), varying from 1 to 14 months (median 3); and there was no success in 11/35 cases (31.5%). Overall, a total remission > 50 % was observed in 24/35 patients (68.5 %). The most serious side effects both ascribed to BLM were observed in the central nervous system (increasing drowsiness and coma) and the lung. This study has shown that in the ultra head and neck malignancies medical treatment can achieve satisfactory results.

scholarly journals Meninges Outside the Meninges: Ectopic Meningiomas and Meningothlelial Proliferations

2021 ◽  
Author(s):  
John A. Ozolek
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Parotid Gland ◽  
Nasal Cavity ◽  
Head And Neck ◽  
Paranasal Sinuses ◽  
Clinicopathological Features ◽  
Anatomical Region ◽  
The Central Nervous System

Extracranial meningiomas have been reported for decades now and have been described in the head and neck; calvarial, nasal cavity, paranasal sinuses, nasopharynx, parotid gland and in various remote anatomical locations systemically. The presence of microanatomical structures for all intents and purposes resembling and having the histopathological characteristics of meninges outside of the central nervous system meninges is uncommon but well-documented. Typically, these lesions are found in the lung or part of hamartomatous/choristomatous lesions and frequently occur in the head and neck anatomical region. The lesion first described by Suster and Rosai termed \"hamartoma of the scalp with ectopic meningothelial elements\" is the prototypical example of lesions with meningothelial elements. We have described recently a similar hamartomatous lesion with meningothelial elements occurring in the tongue. In this chapter, we will review the clinicopathological features of ectopic meningiomas and lesions that contain meningothelial elements and their possible pathogenesis.

Tumours of the central nervous system

2015 ◽  
Author(s):  
Jim Cassidy ◽  
Donald Bissett ◽  
Roy A. J. Spence OBE ◽  
Miranda Payne ◽  
Gareth Morris-Stiff
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Head And Neck ◽  
Head And Neck Cancers ◽  
System P ◽  
The Central Nervous System

A concise, up-to-date overview of the epidemiology, aetiology, pathology, presentation and multi-disciplinary management of head and neck cancers.

Radiation-induced changes in the central nervous system and head and neck.

Radiographics ◽  
1996 ◽  
Vol 16 (5) ◽  
pp. 1055-1072 ◽  
Author(s):  
B M Rabin ◽  
J R Meyer ◽  
J W Berlin ◽  
M H Marymount ◽  
P S Palka ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Head And Neck ◽  
Radiation Induced ◽  
The Central Nervous System ◽  
Induced Changes

scholarly journals Extracellular Vesicles as a Novel Liquid Biopsy-Based Diagnosis for the Central Nervous System, Head and Neck, Lung and Gastrointestinal Cancers: Current and Future Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2792
Author(s):  
Anna Testa ◽  
Emilio Venturelli ◽  
Maria Felice Brizzi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Head And Neck ◽  
Extracellular Vesicles ◽  
Biomarker Discovery ◽  
Lipid Membrane ◽  
Diagnostic Tools ◽  
Gastrointestinal Cancers ◽  
Isolation And Characterization ◽  
The Central Nervous System

Early diagnosis, along with innovative treatment options, are crucial to increase the overall survival of cancer patients. In the last decade, extracellular vesicles (EVs) have gained great interest in biomarker discovery. EVs are bilayer lipid membrane limited structures, released by almost all cell types, including cancer cells. The EV cargo, which consists of RNAs, proteins, DNA, and lipids, directly mirrors the cells of origin. EVs can be recovered from several body fluids, including blood, cerebral spinal fluid (CSF), saliva, and Broncho-Alveolar Lavage Fluid (BALF), by non-invasive or minimally invasive approaches, and are therefore proposed as feasible cancer diagnostic tools. In this review, methodologies for EV isolation and characterization and their impact as diagnostics for the central nervous system, head and neck, lung, and gastrointestinal cancers are outlined. For each of these tumours, recent data on the potential clinical applications of the EV’s unique cargo, alone or in combination with currently available tumour biomarkers, have been deeply discussed.

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