Abnormal Pregnancy: Early Diagnosis by US and Serum Chorionic Gonadotropin Levels

Radiology ◽  
1986 ◽  
Vol 161 (3) ◽  
pp. 854-854 ◽  
Author(s):  
Nicholas Kadar ◽  
Roberto Romero
Keyword(s):  
Early Diagnosis ◽  
Chorionic Gonadotropin ◽  
Abnormal Pregnancy

Abnormal pregnancy: early diagnosis by US and serum chorionic gonadotropin levels.

Radiology ◽  
1986 ◽  
Vol 158 (2) ◽  
pp. 393-396 ◽  
Author(s):  
D A Nyberg ◽  
R A Filly ◽  
D L Filho ◽  
F C Laing ◽  
B S Mahony
Keyword(s):  
Early Diagnosis ◽  
Chorionic Gonadotropin ◽  
Abnormal Pregnancy

scholarly journals Fibrinogen levels helps in early detection of abnormal pregnancies

2016 ◽  
Vol 6 (1) ◽  
pp. 232 ◽  
Author(s):  
Kanchana A. ◽  
Girijavani DSS
Keyword(s):  
Early Diagnosis ◽  
Andhra Pradesh ◽  
Private Hospital ◽  
Fetal Death ◽  
Total Proteins ◽  
Missed Abortion ◽  
Abruptio Placentae ◽  
Abnormal Pregnancy ◽  
Pregnancy Induce Hypertension ◽  
D Dimer

Background: Haemostatic failure as an end result of various complications of pregnancy is an important cause of maternal mortality in India. The main aim of this study is to detect the levels of fibrinogen in abnormal pregnancy i.e. Pregnancy induce hypertension (PIH), Intra uterine fetal death (IUFD), Missed abortion, Abruptio placenta.Methods: Study was conducted on 150 in patients joined in Obstetrics ward private hospital, Andhra Pradesh, 50 are control subjects and 100 are study patients, Out of hundred (100) cases, 40 are PIH, 25 are IUFD, 25 are Missed abortion, and 10 are Abruptio placentae. Estimated for fibrinogen, D-Dimer, total proteins, Albumin.Results: The fibrinogen levels in present study decreased significantly. PIH (Control mean 442.0, S.D ±43.38, Test mean 296.0, S.D ±48.03, p<0.001). IUFD (Control mean 442.0, S.D±43.38, Test mean 262.4, S.D±20.06, p<0.001). Missed abortion (Control mean 442.0, S.D ±43.38, Test mean 250.80, S.D±26.13, p<0.001). Abruptio placentae (Control mean 442.0, S.D±43.38, Test mean 210.5, S.D±87.38, P<0.001). D-dimer levels are estimated semi quantitatively and the levels were found to be increased. Total proteins and albumin are decreased in all the cases, but significantly in PIH (T.P-Control mean6.25, S.D±0.65, Test mean 5.25, S.D±1.57, p<0.001, Albumin- Control mean 2.79, S.D±0.34, Test mean 2.23, S.D±0.59, p<0.001).Conclusions: The estimation of plasma fibrinogen is helpful not only in the early diagnosis of haemostatic failure but also to guide replacement therapy during the fibrinopenic state.

scholarly journals Qualitative Determination of Human Chorionic Gonadotropin in Vaginal Washings for the Early Diagnosis of Premature Rupture of Fetal Membranes

2017 ◽  
Vol 39 (07) ◽  
pp. 317-321
Author(s):  
Camila Dartibale ◽  
Nelson Uchimura ◽  
Luiz Nery ◽  
Angelita Schumeish ◽  
Liza Uchimura ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Fetal Membranes ◽  
Vaginal Fluid ◽  
Premature Rupture ◽  
Significant Difference ◽  
Β Hcg ◽  
Hcg Test

Purpose This study aimed to evaluate and validate the qualitative human chorionic gonadotropin β subunit (β-hCG) test of the vaginal fluid washings of pregnant women with premature rupture of fetal membranes (PROM). Methods Cross-sectional study of pregnant women between gestational weeks 24 and 39 who underwent consultations in one of our institutions. They were divided into two groups: group A (pregnant women clinically diagnosed with PROM) and group B (pregnant women without loss of amniotic liquid). The patients were subjected to a vaginal fluid washing with 3 mL of saline solution, which was aspirated subsequently with the same syringe. The solution was immediately sent to the laboratory to perform the vaginal β-hCG test with cut-off points of 10 mIU/mL (β-hCG-10) and/or 25 mIU/mL (β-hCG-25). Results The β-hCG-10 test of the vaginal secretion was performed in 128 cases. The chi-squared test with Yates' correction showed a statistically significant difference between the 2 groups (p = 0.0225). The sensibility, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy parameters were 77.1%, 43.6%, 52.3%; 70.4%; and 58.6% respectively. The β-hCG-25 test of the vaginal washing was performed in 49 cases. The analysis by Fisher's exact test showed a statistically significant difference between the groups (p = 0.0175). The sensibility, specificity, PPV, NPV, and accuracy parameters were 44.4%, 87.1%, 66.6%; 72.9%; and 71.4% respectively. Conclusions The β-hCG-25 test showed better accuracy for the diagnosis of PROM, and can corroborate the early diagnosis of PROM because it is a simple and quick exam.

scholarly journals Gastric Cancer in the Setting of Persistently Elevated Human Chorionic Gonadotropin: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
LaToya R. Walker ◽  
Brian Erler
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Stage Iv ◽  
Signs And Symptoms ◽  
Metastatic Carcinoma ◽  
Abnormal Pregnancy ◽  
Multiple Biopsies ◽  
Signet Ring ◽  
Poorly Differentiated ◽  
Diffuse Sclerosis

A 35-year-old woman presented to the emergency room for the evaluation of failed surgical and medical management of a suspected ectopic pregnancy. When imaging studies were performed, she had lymphadenopathy and diffuse sclerosis of the osseous framework. Multiple biopsies were performed and revealed poorly differentiated metastatic carcinoma with signet ring features. Esophagogastroduodenoscopy confirmed the findings of a Stage IV gastric adenocarcinoma. Signs and symptoms of gastric carcinoma are vague. However, to our knowledge, an elevation in human chorionic gonadotropin (hCG) is not an associated finding. Persistence of hCG has many causes from abnormal pregnancy to menopause and other forms of cancer.

scholarly journals An unusual cause of gynaecomastia in a male

2019 ◽  
Vol 2019 ◽  
Author(s):  
Tejhmal Rehman ◽  
Ali Hameed ◽  
Nigel Beharry ◽  
J Du Parcq ◽  
Gul Bano
Keyword(s):  
Early Diagnosis ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Embryo Implantation ◽  
List Type ◽  
High Concentration ◽  
Gestational Choriocarcinoma ◽  
Beta Human Chorionic Gonadotropin ◽  
Neoplastic Process ◽  
High Index Of Suspicion

Summary Beta-human chorionic gonadotropin (βhCG) is normally produced by syncytiotrophoblasts of the placenta during pregnancy and aids embryo implantation. However, it is also secreted in varying amounts in non-pregnant conditions commonly heralding a neoplastic process. We present a case of 50-year-old man, who presented with bilateral gynaecomastia with elevated testosterone, oestradiol, suppressed gonadotropins with progressively increasing levels of human chorionic gonadotropin (hCG). Biochemical and radiological investigations including ultrasonography of testes, breast tissue, MRI pituitary and CT scan full body did not identify the source of hCG. FDG PET scan revealed a large mediastinal mass with lung metastasis. Immunostaining and histological analysis confirmed the diagnosis of primary choriocarcinoma of the mediastinum. It is highly aggressive and malignant tumor with poor prognosis. Early diagnosis and management are essential for the best outcome. Learning points: High βhCG in a male patient or a non-pregnant female suggests a paraneoplastic syndrome. In the case of persistently positive serum hCG, exclude immunoassay interference by doing the urine hCG as heterophilic antibodies are not present in the urine. Non-gestational choriocarcinoma is an extremely rare trophoblastic tumor and should be considered in young men presenting with gynaecomastia and high concentration of hCG with normal gonads. A high index of suspicion and extensive investigations are required to establish an early diagnosis of extra-gonadal choriocarcinoma. Early diagnosis is crucial to formulate optimal management strategy and to minimize widespread metastasis for best clinical outcome.

scholarly journals Utility of imprint smear in early diagnosis of abnormal pregnancy(abortion and ectopic pregnancy).

1997 ◽  
Vol 36 (6) ◽  
pp. 608-612
Author(s):  
Hiroshi SUZUKI ◽  
Hiroshi IURA ◽  
Kazue NOMOTO ◽  
Sachiko TAKEDA ◽  
Shinichi TATE ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Ectopic Pregnancy ◽  
Abnormal Pregnancy
Sign in / Sign up

Export Citation Format

Share Document