scholarly journals Fibrinogen levels helps in early detection of abnormal pregnancies

2016 ◽  
Vol 6 (1) ◽  
pp. 232 ◽  
Author(s):  
Kanchana A. ◽  
Girijavani DSS
Keyword(s):  
Early Diagnosis ◽  
Andhra Pradesh ◽  
Private Hospital ◽  
Fetal Death ◽  
Total Proteins ◽  
Missed Abortion ◽  
Abruptio Placentae ◽  
Abnormal Pregnancy ◽  
Pregnancy Induce Hypertension ◽  
D Dimer

Background: Haemostatic failure as an end result of various complications of pregnancy is an important cause of maternal mortality in India. The main aim of this study is to detect the levels of fibrinogen in abnormal pregnancy i.e. Pregnancy induce hypertension (PIH), Intra uterine fetal death (IUFD), Missed abortion, Abruptio placenta.Methods: Study was conducted on 150 in patients joined in Obstetrics ward private hospital, Andhra Pradesh, 50 are control subjects and 100 are study patients, Out of hundred (100) cases, 40 are PIH, 25 are IUFD, 25 are Missed abortion, and 10 are Abruptio placentae. Estimated for fibrinogen, D-Dimer, total proteins, Albumin.Results: The fibrinogen levels in present study decreased significantly. PIH (Control mean 442.0, S.D ±43.38, Test mean 296.0, S.D ±48.03, p<0.001). IUFD (Control mean 442.0, S.D±43.38, Test mean 262.4, S.D±20.06, p<0.001). Missed abortion (Control mean 442.0, S.D ±43.38, Test mean 250.80, S.D±26.13, p<0.001). Abruptio placentae (Control mean 442.0, S.D±43.38, Test mean 210.5, S.D±87.38, P<0.001). D-dimer levels are estimated semi quantitatively and the levels were found to be increased. Total proteins and albumin are decreased in all the cases, but significantly in PIH (T.P-Control mean6.25, S.D±0.65, Test mean 5.25, S.D±1.57, p<0.001, Albumin- Control mean 2.79, S.D±0.34, Test mean 2.23, S.D±0.59, p<0.001).Conclusions: The estimation of plasma fibrinogen is helpful not only in the early diagnosis of haemostatic failure but also to guide replacement therapy during the fibrinopenic state.

D-dimer as a marker for early diagnosis of acute mesenteric ischemia

2006 ◽  
Vol 117 (4) ◽  
pp. 463-467 ◽  
Author(s):  
Hüseyin Altinyollar ◽  
Mustafa Boyabatli ◽  
Uğur Berberoğlu
Keyword(s):  
Early Diagnosis ◽  
Mesenteric Ischemia ◽  
Acute Mesenteric Ischemia ◽  
D Dimer

scholarly journals FM Combined With NIHSS Score Contributes to Early AIS Diagnosis and Differential Diagnosis of Cardiogenic and Non-Cardiogenic AIS

2021 ◽  
Vol 27 ◽  
pp. 107602962110001
Author(s):  
Dan Wu ◽  
Yong’e Liu
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Diagnostic Efficacy ◽  
Stroke Treatment ◽  
Nihss Score ◽  
Stroke Group ◽  
Diagnosis And Classification ◽  
Toast Classification ◽  
Thrombotic Diseases ◽  
D Dimer

A growing researchers have suggested that fibrin monomer (FM) plays an important role in early diagnosis of thrombotic diseases. We explored the application of FM in the diagnosis and classification of acute ischemic stroke (AIS). The differences in FM, D-dimer, and NIHSS scores between different TOAST (Trial of ORG 10172 in Acute Stroke Treatment) types were analyzed with one-way ANOVA; the correlation between FM, D-dimer and NIHSS score in patients with different TOAST classification was analyzed by Pearson linear correlation. The ROC curve was utilized to analyze the diagnostic performance. 1. FM was more effective in diagnosing patients with AIS than D-dimer. 2. The FM level in cardiogenic AIS was significantly different from that in non-cardiogenic patients ( P < 0.05); the NIHSS score in cardiogenic stroke was significantly higher than in atherosclerotic and unexplained stroke group. Whereas, no statistical difference was observed in the D-dimer level between these groups ( P > 0.05). 3. The correlation between FM and NIHSS scores in the cardiogenic (r = 0.3832) and atherosclerotic (r = 0.3144) groups was statistically significant. 4. FM exhibited the highest diagnostic efficacy for cardiogenic AIS; furthermore, FM combined with the NIHSS score was more conducive to the differential diagnosis of cardiogenic and non-cardiogenic AIS. FM detection contributes to the early diagnosis of AIS, and is important for the differential diagnosis of different TOAST types of AIS. Moreover, FM combined with the NIHSS score is valuable in the differential diagnosis of cardiogenic and non-cardiogenic AIS.

scholarly journals CORRELATION OF D-DIMER LEVEL WITH THE PRESENCE AND SEVERITY OF PULMONARY EMBOLISM ON COMPUTED TOMOGRAPHY PULMONARY ANGIOGRAPHY

2020 ◽  
pp. 33-34
Author(s):  
Mantavya Patel ◽  
Sanjay Paliwal ◽  
Rachit Saxena
Keyword(s):  
Computed Tomography ◽  
Pulmonary Embolism ◽  
Early Diagnosis ◽  
Pulmonary Angiography ◽  
Clinical Suspicion ◽  
Early Prediction ◽  
Computed Tomography Pulmonary Angiography ◽  
Negative Prediction ◽  
D Dimer

Introduction: Early diagnosis of pulmonary embolism can reduce morbidity and motility. D-dimer is well known parameter having high negative prediction value. This study focused on role of D-dimer in early prediction of presence and severity of pulmonary embolism. Material and Methods: Thirty patients with clinical suspicion of pulmonary embolism along with high D-dimer value were included in this study. All selected patients underwent computed tomography pulmonary angiography assessment. D-dimer value was correlated with presence and proximity of pulmonary embolism. Results: Out of thirty selected patients 50% had pulmonary embolism on computed tomography pulmonary angiography assessment. D-dimer value correlated well with presence and proximity of pulmonary embolism. Conclusion: D-dimer value more than 4000 ng/ml had high positive prediction value (79%) in suspected clinical cases. Value more than 8000 ng/ml further improve value to nearly 100% in suspected cases.

scholarly journals The Significance of Routine Biochemical Markers in Patients With Sepsis

2020 ◽  
Author(s):  
Yan Meng ◽  
Yue Wang ◽  
Wenbin Qiao ◽  
Yumei LIU ◽  
Liang Wang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Early Diagnosis ◽  
Diagnostic Criteria ◽  
Assessment Tool ◽  
Diagnostic Value ◽  
Sepsis Group ◽  
Control Group ◽  
Diagnostic Efficiency ◽  
Infection Group ◽  
D Dimer

Abstract Background: Sepsis is a highly complex and fatal syndrome. It is the main cause of death in the intensive care unit. Early diagnosis is beneficial to reduce the mortality of sepsis and improve the prognosis of patients. Therefore, we look forward to finding cheap and fast diagnostic criteria to quickly assess the patient's condition.Methods: This is a retrospective study. The study enrolled 499 patients in the First Affiliated Hospital of Xinjiang Medical University from January 1, 2018 to June 22, 2020, and 96 healthy cases in the same period. Using the diagnostic criteria of bacterial infection, SIRS criteria and Sepsis-2 consensus criteria, 499 patients and 96 healthy cases were divided into 4 groups: sepsis group (n=300), SIRS group (n=151), infection group (n= 48), the control group (n=96). We collected the results of routine laboratory tests, inflammation indicators and blood culture results of these patients. Results: The sepsis group compared with the control group, MCV, NE, WBC, PLT, HB, D-Dimer, PT, CRP, PCT, IL-6, ALB, TBIL, Cr, LAC, CysC and BNP were statistically significant. D-dimer, CRP and PCT have higher diagnostic efficiency. Compared with the difference between the infection group and the SIRS group, PLT and IL-6 are statistically significant, and have a certain diagnostic value. Sepsis group VS infection group, WBC, IL-6, NE and TBIL showed statistical differences in the comparison. The AUC of NE was 67.6, which was the largest among the three. The specificity (95.8%) was the highest, but the sensitivity (49%) was low.Conclusions: This retrospective study shows that NE, WBC, and D-dimer can help in the early diagnosis of sepsis. D-dimer performs best. WBC and NE may have a differential diagnosis significance between the sepsis group and the infection group. This result can provide a timely and convenient assessment tool for early diagnosis of sepsis.

Predictive Value of Combination of D-dimer and Fibrinogen in Diagnosing Acute CVST

2021 ◽  
pp. 097275312110631
Author(s):  
Abhishek Pathak ◽  
Varun Kumar Singh ◽  
Anand Kumar ◽  
Vijaya Nath Mishra ◽  
Deepika Joshi ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Predictive Value ◽  
Sinus Thrombosis ◽  
Care Center ◽  
Tertiary Care ◽  
Cerebral Venous Sinus Thrombosis ◽  
Latex Agglutination ◽  
D Dimer ◽  
Latex Agglutination Assay

Background: Cerebral venous sinus thrombosis (CVST) is an uncommon subtype of stroke, and the role of D-dimer and fibrinogen in early diagnosis of CVST has been studied with varying results. The present study aims to study the role of the combination of D-dimer and fibrinogen in early diagnosis of acute CVST. Methods: Forty consecutive confirmed acute CVST cases admitted at a tertiary care center were recruited for the study. D-dimer and fibrinogen were assessed by a rapid semiquantitative latex agglutination assay. Results: Out of the 40 CVST patients, 21 (52.50%) were females. The mean age of the patients was 37.58 years ± 19.17 years. Common clinical features were headache ( N = 38 [95%]), papilloedema ( N = 15 [37.5%]), and seizures ( N = 12 [30%]). Although the sensitivity (75%) of the combination of D-dimer and fibrinogen assay was lower than that of D-dimer or fibrinogen alone, the specificity and positive predictive value (75% each) was higher. Conclusions: The combination of D-dimer and fibrinogen testing may aid in an early diagnosis of acute CVST and in better management.

Urinary Chorionic Gonadotrophin Determination

1966 ◽  
Vol 12 (9) ◽  
pp. 577-585 ◽  
Author(s):  
Derek Watson
Keyword(s):  
Normal Values ◽  
First Trimester ◽  
Diagnostic Value ◽  
Chorionic Gonadotrophin ◽  
Routine Method ◽  
Normal Range ◽  
Missed Abortion ◽  
Abnormal Pregnancy ◽  
Endogenous Production ◽  
First Trimester Of Pregnancy

Abstract Successful laboratory tests for early pregnancy utilize the endogenous production and excretion of chorionic gonadotrophin (CG). There is wide variation in sensitivity and specificity of various biological and commercially available immunochemical methods for determining urinary CG levels. Normal values for immunochemically reactive CG during the first trimester of pregnancy are given. Serial determinations of CG have diagnostic value in assessing various abnormal pregnancy states. An abnormally increased urinary output of CG is observed in some neoplasms—e.g., chorionepithelioma, and a rapidly rising CG level is strongly suggestive of molar pregnancy. Urinary CG levels falling below the normal range mayindicate an ectopic pregnancy or an inevitable, incomplete, or "missed" abortion. The immunochemical CG determination also offers a sensitive, simple, and convenient routine method for following patients who have been treated for hydatidiformmole or chorionepithelioma.

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